Identification of host restriction factors that block respiratory virus infection

鉴定阻止呼吸道病毒感染的宿主限制因素

• 批准号: nhmrc : 1143154
• 负责人: Dr Sarah Londrigan
• 金额: $ 64.7万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-host-restriction-virus-infection/1319881
• 关键词: Identification; host; restriction; factors; block

Following inhalation, respiratory viruses can infect and grow in airway epithelial cells. Although immune cells such as macrophages are also susceptible to infection, this is generally abortive and new viruses are not released. This project will identify proteins induced in macrophages that block respiratory viruses and prevent their spread in the airways. We will also define mechanisms by which some virulent strains overcome this block to grow in macrophages.

吸入后，呼吸道病毒可感染并在气道上皮细胞中生长。虽然免疫细胞如巨噬细胞也容易受到感染，但通常是失败的，新的病毒不会释放出来。该项目将识别巨噬细胞中诱导的蛋白质，这些蛋白质可以阻断呼吸道病毒并防止它们在呼吸道中传播。我们还将定义一些毒性菌株克服这一障碍在巨噬细胞中生长的机制。