Cell surface lectin receptors for attachment and entry of influenza viruses into cells of the innate immune system

用于流感病毒附着和进入先天免疫系统细胞的细胞表面凝集素受体

• 批准号: nhmrc : 1027545
• 负责人: Dr Sarah Londrigan
• 金额: $ 35.35万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-surface-lectin-innate-immune/110578
• 关键词: Cell; surface; lectin; receptors; attachment

Influenza virus is a leading cause of respiratory infection and death worldwide. Infection of humans is initiated when the virus contacts cells lining the respiratory tract. Infection of epithelial cells leads to virus amplification whereas infection of immune cells results in virus destruction. Despite extensive research efforts, it is not clear how the virus infects these cells. This project aims to identify receptors on human cells used by influenza virus to attach to and infect immune cells.

流感病毒是全世界呼吸道感染和死亡的主要原因。当病毒接触呼吸道内壁细胞时，就会开始感染人类。上皮细胞的感染导致病毒扩增，而免疫细胞的感染导致病毒破坏。尽管进行了大量的研究工作，但仍不清楚病毒如何感染这些细胞。该项目旨在识别流感病毒用于附着和感染免疫细胞的人体细胞上的受体。