Tissue Procurement

28年来，组织采购共享资源（TPSR）在最近两次CCSG审查中被评为 “卓越”是OSUCCC研究使命的重要组成部分。TPSR 从实体肿瘤中获取恶性和正常组织并提供给OSUCCC会员。的 TPSR是俄勒冈州立大学大型组织库网络的一部分，名为“人类组织资源网络”塔尔 还包括：NCI资助的合作人体组织网络、NCI资助的癌症和白血病 B组（CALGB）病理学协调办公室和标本库，国家癌症研究所资助的艾滋病研究所 银行，组织档案服务和研究组织学核心设施。强大的机构和 各小组的协调支持使TPSR能够汇集专业知识和工具， 组织资源项目，如加强对OSUCCC的支持。的运行管理和 技术人员提供了高质量和一致的组织标本，这可能对所有六个 OSUCCC科学计划。这项服务主要是一项前瞻性的组织采购服务 用于基础科学应用。然而，现在有一个新的努力，包括术前（活检）和术后 OSUCCC研究者采集标本用于临床相关研究。 TPSR有效地完成了基础科学和临床材料的收集， 这两种方法有着根本的不同，但对OSUCCC的目标都很重要。TPSR工作人员提供高质量的 控制研究标本，并与病理学家和OSUCCC研究者直接互动， 更好地协助组织的采购和促进假设驱动的癌症研究。TPSR已经 被五个OSUCCC科学项目使用，其中分子生物学和癌症 遗传学计划。所有（100%）的TPSR采购都由OSUCCC成员使用， 激光捕获显微切割活动一直是由OSUCCC成员，但在过去的四年中， 其中65%的资金来自CCSG。TPSR寻求继续利用强大的机构 支持其服务，以满足OSUCCC未来不断扩大的需求。实际上，在本申请中， CCSG支持仅占TPSR总成本的21.6%。医院之间的合作， OSUCCC和病理学系提供这项服务是真正的协同作用的证明， 为OSUCCC会员资格增添了丰富的价值。

For 28 years, the Tissue Procurement Shared Resource (TPSR), rated in the last two CCSG reviews as "outstanding", has been an important component of the research mission in the OSUCCC. The TPSR procures and provides malignant and normal tissues from solid tumors to the OSUCCC membership. The TPSR is part of a large tissue bank network at OSU entitled, "The Human Tissue Resource Network" thal also includes: The NCI-funded Cooperative Human Tissue Network, the NCI-funded Cancer and Leukemia Group B (CALGB) Pathology Coordinating Office and specimen banks, the NCI-funded AIDS Malignancy Bank, the Tissue Archives Services and the Research Histology Core Facility. The strong institutional and coordinated support of groups compliments the TPSR to bring together the expertise and tools to direct tissue resource projects such as to enhance the support of the OSUCCC. The operation management and technical staff provide high quality and consistent tissue specimens that will likely prove critical to all six of the OSUCCC scientific programs. This service has been primarily a prospective tissue procurement service for basic science applications. However there is now a new effort to include pre-surgical (biopsy) and postsurgical collection of specimens for the purposes of clinical correlative studies by OSUCCC investigators. The TPSR efficiently accomplishes both basic science and clinical collection of materials that are fundamentally different yet both important to the goals of the OSUCCC. The TPSR staff provides quality control of the research specimen and direct interaction with pathologists and OSUCCC investigators to better assist in procurement of tissues and to foster hypothesis-driven cancer research. The TPSR has been used by five of the OSUCCC scientific programs with heavy use from the Molecular Biology and Cancer Genetics Program. All (100%) of the TPSR procurement usage is by OSUCCC members and 69.5% of the Laser Capture Microdissection activity has been by OSUCCC members, yet over the past four years only 65% of it's funding came from the CCSG. The TPSR seeks to continue to leverage strong institutional support of its services to provide for the expanding future needs for the OSUCCC. Indeed, in this application the CCSG support represents only 21.6% of the total TPSR cost. The collaboration between the hospitals, OSUCCC and the Department of Pathology to provide this service is demonstration of true synergy that adds ample value to the OSUCCC membership.