Biorepository and Biospecimen

项目随附资料（见说明）： 2008年，OSUCCC将OSUCCC组织采购共享资源重组为生物储存库和生物标本资源（BBR）。生物储存库和生物标本资源的目标是提供一个组织良好和集中的生物储存库，符合NCI为癌症研究提供高质量生物标本的最佳实践。BBR由Scott朱厄尔博士领导，他在组织采购和库存的政策、管理和运营方面拥有丰富的经验。的BBR OSUCCC负责监督OSUCCC研究人员从实体瘤中获取恶性、良性、病变和未受累（正常）组织，并已扩展为一个集中的生物标本库系统，该系统具有普遍的患者知情同意，可用于捐赠生物标本（组织、血液和液体）和注释的临床数据，供未来研究使用。使用caGRID技术，这些标本与注释的患者健康和医疗信息相关联，从而提高了这些信息的质量和可用性。 研究用的生物标本 自签署患者知情同意书以来，BBR在过去10个月内收集了10，000多份样本，另外还有2，500多份组织标本可供研究者立即使用。在本报告所述期间（2004-2009年），BBR向所有六个OSUCCC科学项目提供了11，000多份组织标本。BBR的重要功能包括：在注册时获得患者知情同意的知情同意团队;注释到 生物标本;收集的集中管理;生物标本的处理和储存;以及资源的安全和保护，例如空的备用冰柜、用于电力备用保护的柴油发电机、对所有冰柜的24/7监测以及应急小组。 BBR利用caTissueSuite（一个caBIG应用程序）记录和监测生物储存库库存。一个基于网络的应用程序已经开发出来，这将使研究人员能够确定组织是否存在于BBR中具有特定的表型特征。随着知情同意扩展到所有临床研究中心， 创建一个巨大的研究生物标本库，与注释的临床数据相关联， OSUCCC调查人员无与伦比的资源。出色的机构支助对实现 普遍知情同意进程的实施，并确保了 这一宝贵的共享资源。 在过去的一年里，尽管75.26%的BBR使用量来自CCSG同行评审， 调查人员和整体OSUCCC的使用率为96.77%，只有24.9%的BBR预算支持来自 从CCSG。

PROJECT SUIVIMARY (See instructions): In 2008 the OSUCCC reorganized the OSUCCC Tissue Procurement Shared Resource into the Biorepository and Biospecimen Resource (BBR). The goal of the Biorepository and Biospecimen Resource is to provide a well-organized and centralized biorepository that meets the best practices of the NCI for high quality biospecimens for cancer research. The BBR is directed by Dr. Scott Jewell who has extensive experience in the policy, management and operations in tissue procurement and banking. The BBR oversees the procurement of malignant, benign, diseased and uninvolved (normal) tissues from solid tumors for OSUCCC researchers and has expanded into a centralized biospecimen banking system with universal patient informed consent for the donation of biospecimens (tissues, bloods, and fluids) and annotated clinical data for future research. Using caGRID technology, these specimens are linked with annotated patient health and medical information, thereby enhancing the quality and usability of these biospecimens for research. The BBR has collected over 10,000 samples in the last 10 months .since the inception of patient informed consent and an additional 2,500+ tissue specimens for immediate use to investigators. During this reporting period (2004-2009) the BBR provided all six OSUCCC Scientific Programs with more than 11,000 tissue specimens. Valued features of the BBR include: a consent team that obtains patient informed consent at the point of registration; patient medical and health information that is annotated to the biospecimen; centralized management of the collection; processing and storage of the biospecimens; and security and protection of the resource, such as empty backup freezers, diesel generator for electrical backup protection, 24/7 monitoring of all freezers, and an emergency response team. The BBR utilizes caTissueSuite (a caBIG application) to record and monitor the biorepository inventory. A web-based application has been developed that will allow researchers to determine if tissue exists in the BBR with particular phenotypic characteristics. As informed consent expands to all clinical sites, this will create a vast repository of viable research biospecimens linked with annotated clinical data, providing an unparalleled resource for OSUCCC investigators. Outstanding institutional support has been critical to the implementation of the universal informed consent process and has ensured the continued growth and success of this highly valued shared resource. This past year, although 75.26% of the BBR usage was from CCSG peer-reviewed, funded OSUCCC investigators and overall OSUCCC usage was 96.77%, only 24.9% of the BBR budgetary support came from the CCSG.