Tissue Procurement

组织采购

• 批准号: 7630223
• 负责人: Scott D Jewell
• 金额: $ 25.37万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7630223
• 关键词: Acquired Immunodeficiency Syndrome; Archives; Authorization documentation; Basic Science; Biopsy; Cancer Center Support Grant; Cancer and Leukemia Group B; Clinical; Clinical Trials; Collaborations; Collection; Cooperative Human Tissue Network; Core Facility; Correlative Study; Education; Fostering; Funding; Future; Genetic Programming; Goals; Health Insurance Portability and Accountability Act; Health Services Research; Histology; Hospitals; Human; Institutes; Laboratories; Malignant - descriptor; Malignant Neoplasms; Mission; Molecular Biology; Normal tissue morphology; Operative Surgical Procedures; Pathologist; Pathology; Purpose; Quality Control; Rate; Research; Research Ethics Committees; Research Personnel; Resource Sharing; Science; Services; Solid Neoplasm; Specimen; Support Groups; System; The Comprehensive Cancer Center Arthur G James Cancer Hospital and Richard J Solove Research Institute at Ohio State University; Tissue Banking; Tissue Banks; Tissue Procurements; Tissues; User Compliance; Validation; anticancer research; base; cancer genetics; cost; human tissue; improved; laser capture microdissection; member; programs; prospective; sample collection; tissue resource; tool

For 28 years, the Tissue Procurement Shared Resource (TPSR), rated in the last two CCSG reviews as "outstanding", has been an important component of the research mission in the OSUCCC. The TPSR procures and provides malignant and normal tissues from solid tumors to the OSUCCC membership. The TPSR is part of a large tissue bank network at OSU entitled, "The Human Tissue Resource Network" thal also includes: The NCI-funded Cooperative Human Tissue Network, the NCI-funded Cancer and Leukemia Group B (CALGB) Pathology Coordinating Office and specimen banks, the NCI-funded AIDS Malignancy Bank, the Tissue Archives Services and the Research Histology Core Facility. The strong institutional and coordinated support of groups compliments the TPSR to bring together the expertise and tools to direct tissue resource projects such as to enhance the support of the OSUCCC. The operation management and technical staff provide high quality and consistent tissue specimens that will likely prove critical to all six of the OSUCCC scientific programs. This service has been primarily a prospective tissue procurement service for basic science applications. However there is now a new effort to include pre-surgical (biopsy) and postsurgical collection of specimens for the purposes of clinical correlative studies by OSUCCC investigators. The TPSR efficiently accomplishes both basic science and clinical collection of materials that are fundamentally different yet both important to the goals of the OSUCCC. The TPSR staff provides quality control of the research specimen and direct interaction with pathologists and OSUCCC investigators to better assist in procurement of tissues and to foster hypothesis-driven cancer research. The TPSR has been used by five of the OSUCCC scientific programs with heavy use from the Molecular Biology and Cancer Genetics Program. All (100%) of the TPSR procurement usage is by OSUCCC members and 69.5% of the Laser Capture Microdissection activity has been by OSUCCC members, yet over the past four years only 65% of it's funding came from the CCSG. The TPSR seeks to continue to leverage strong institutional support of its services to provide for the expanding future needs for the OSUCCC. Indeed, in this application the CCSG support represents only 21.6% of the total TPSR cost. The collaboration between the hospitals, OSUCCC and the Department of Pathology to provide this service is demonstration of true synergy that adds ample value to the OSUCCC membership.

28年来，组织采购共享资源(TPSR)在最近两次CCSG审查中被评为 “杰出”，一直是OSUCCC研究任务的重要组成部分。《TPSR》 获取和提供来自实体肿瘤的恶性和正常组织给OSUCCC成员。这个 TPSR是俄亥俄州立大学一个大型组织银行网络的一部分，名为“人类组织资源网络”THAL 还包括：NCI资助的合作人体组织网络，NCI资助的癌症和白血病 B组(CALGB)病理协调办公室和标本库，NCI资助的艾滋病恶性肿瘤 银行、组织档案服务和研究组织学核心设施。强大的机构和 各小组的协调支持是对TPSR的补充，以汇集专门知识和工具来指导 组织资源项目，如加强对OSUCCC的支持。运营管理和 技术人员提供高质量和一致的组织标本，这些标本可能被证明对所有六个 OSUCCC科学计划。这项服务主要是未来的组织采购服务。 用于基础科学应用。然而，现在有了一项新的努力，包括手术前(活组织检查)和手术后 为OSUCCC调查人员进行临床相关研究而收集的标本。 TPSR有效地完成了基础科学和临床材料的收集，这些材料 从根本上不同，但对OSUCCC的目标都很重要。TPSR工作人员提供质量 控制研究标本，并与病理学家和OSUCCC调查人员直接互动以 更好地协助采购组织，并促进假说驱动的癌症研究。TPSR已经被 被五个OSUCCC科学计划使用，大量使用来自分子生物学和癌症 遗传学项目。所有(100%)TPSR采购用途由OSUCCC成员和69.5%的OSUCCC成员使用 激光捕获显微切割活动一直由OSUCCC成员进行，但在过去四年里 其中65%的资金来自CCSG。TPSR寻求继续利用强大的机构杠杆 支持其服务，以满足OSUCCC未来不断扩大的需求。事实上，在此应用程序中 CCSG支持仅占TPSR总成本的21.6%。医院之间的合作， OSUCCC和病理科提供这项服务是真正协同的证明 为OSUCCC成员资格增加了充足的价值。