Leukemia Tissue Bank

白血病组织库

• 批准号: 7630214
• 负责人: Sherif S Farag
• 金额: $ 5.96万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7630214
• 关键词: Acute; Appointment; Arts; Aspirate substance; Basic Science; Biological; Blood; Blood Component Removal; Blood specimen; Bone Marrow; Cancer and Leukemia Group B; Centrifugation; Clinical; Clinical Data; Clinical Pathology; Clinical Research; Clinical Trials; Collaborations; Collection; Commit; Confidentiality; Consent; Country; Cytogenetics; DNA; Data; Databases; Diagnosis; Diagnostic; Disease; Doctor of Medicine; Doctor of Philosophy; Drug Kinetics; Eastern Cooperative Oncology Group; Freezing; Funding; Germ Lines; Goals; Growth; Hematologic Neoplasms; Hematologist; Heterogeneity; Human Resources; Informed Consent; Institution; Laboratories; Leadership; Left; Lymphoma; Malignant Neoplasms; Medical Oncologist; Mission; Molecular; Molecular Analysis; Molecular Cytogenetics; Natural History; Normal tissue morphology; Numbers; Oncology Group; Operative Surgical Procedures; Outcome; Pathologic; Pathologist; Patients; Personal Satisfaction; Plasma; Play; Policies; Procedures; Process; Property; Protocols documentation; Publications; Quality Control; Regulation; Research; Research Ethics Committees; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Retrieval; Role; Roswell Park Cancer Institute; Sampling; Shipping; Ships; Solid; Solid Neoplasm; Source; Southwest Oncology Group; Specimen; Standards of Weights and Measures; Support of Research; Surgeon; Swab; The Comprehensive Cancer Center Arthur G James Cancer Hospital and Richard J Solove Research Institute at Ohio State University; Time; Tissue Banks; Tissue Procurements; Tissue Sample; Tissues; Training; Translating; Translations; Tumor Bank; Week; Workload; base; chronic leukemia; day; density; experience; follow-up; interest; leukemia; leukemia/lymphoma; member; outcome forecast; radiologist; repository; response; sample collection; stem; success; therapeutic target; tissue resource

The ability to successfully translate basic research in leukemia to the clinical setting, as well as to better understand the relevance of observed clinical phenomena through laboratory-based research, is greatly facilitated by the availability of an extensive repository of tissue samples, with accompanying complete pathologic and clinical data, procured from leukemia patients. The OSUCCC Leukemia Tissue Bank Shared Resource (LTBSR), separate and distinct from the CALGB Leukemia Tissue Bank, is a shared resource established in 1997 with over 4,500 patient samples procured from 762 consented leukemia patients at OSU. The infrastructure of the OSUCCC LTBSR is well-established and is directly under our leadership. Specifically we have a large leukemia tissue repository, including both leukemic tissue and normal tissue germ line DNA, accompanied in all cases with complete pathologic, cytogenetic and clinical data for ready correlation of clinical and biological results. In addition, all the essentials of effective leukemia tissue bank management, including the activities of tissue collection, quality control of specimens, tissue storage, procurement of initial and follow-up samples and their pathology and clinical information, data entry and database management, and patient consent and confidentiality are very well developed. Furthermore, the procedures for prioritizing and distributing tissue to a large base of investigators within the OUCCC are effectively in place. Finally, our success in managing this large leukemia tissue resource can be seen in the documented sample collection for and sample distribution to all leukemia researchers within the CCC and 28 publications where the OSUCCC LTBSR has played a significant role. Against this background, we believe that this Shared Resource will function well in the support of the research mission of the OSUCCC in )roducing high-quality basic and clinical research in hematological malignancy. Currently the OSUCCC _TBSR is funded solely with OSUCCC/institutional support. The Specific Aims of this Shared Resource are, therefore, to: 1) Continue to provide a central collection, processing and a state-of-the-art repository for samples collected from leukemia patients treated on OSU protocols, and 2) Provide materials from the LTBSR to interested investigators within OSUCCC, as well as to outside interested investigators involved in collaborative studies with OSU, who examine relevant cellular and molecular properties of leukemia.

成功地将白血病基础研究转化为临床环境的能力，以及更好地 通过实验室研究了解观察到的临床现象的相关性， 通过提供广泛的组织样本库，以及随附的完整的 从白血病患者中获得的病理和临床数据。OSUCCC白血病组织库 共享资源（LTBSR），独立于CALGB白血病组织库，是一个共享的 1997年建立的资源，从762例同意的白血病患者中采购了4，500多份患者样本 患者在OSU OSUCCC LTBSR的基础设施完善，直接隶属于我们的 领导具体来说，我们有一个大型的白血病组织库，包括白血病组织和 所有病例均伴有完整的病理、细胞遗传学和临床表现， 数据用于临床和生物学结果的快速关联。此外，有效治疗白血病的所有要素 组织库管理，包括组织采集、标本质量控制、组织 初始和随访样本及其病理学和临床信息的储存、获取、数据录入 和数据库管理，以及患者同意和保密性都得到了很好的发展。此外，委员会认为， OUCCC内对大量研究者进行组织优先排序和分配的程序如下 有效到位。最后，我们在管理这种大型白血病组织资源方面的成功可以从以下方面看到： 记录CCC内所有白血病研究人员的样本采集和样本分发， OSUCCC LTBSR发挥了重要作用的出版物。在此背景下，我们认为 这一共享资源将在支持OSUCCC的研究使命方面发挥良好作用， ）开展高质量的恶性血液病基础和临床研究。目前，OSUCCC _TBSR仅由OSUCCC/机构支持资助。本共享资源的具体目标是， 1）继续提供中央收集、处理和最先进的储存库， 从接受OSU方案治疗的白血病患者中收集的样本，以及2）提供来自 向OSUCCC内部的相关研究者以及参与以下研究的外部相关研究者提供LTBSR 与俄勒冈州立大学的合作研究，他们检查白血病的相关细胞和分子特性。