Compact, Neon/Cryocooled NMR Magnets Assembled from Superconducting YBCO Annuli

设计、制造和操作200 MHz/38 mm“台式”核磁共振“环”磁体(第二阶段：300 MHz/43 mm和500 MHz/43 mm磁体)的两阶段计划的第一阶段的具体目标有四个：1)基于创新的设计/操作概念设计、制造和操作200 MHz/38 mm直径的原型“核磁共振”磁体，该概念特别适合用于高分辨率“微核磁共振”谱的新型永久模式核磁共振磁体；2)用原型演示环形磁铁的独特功能，它允许磁铁在一个地点(制造商)被通电并运输到另一个地点(用户)，同时磁铁保持其核磁共振质量的磁场；3)完成并演示一种“磁场调整”技术，允许“微调”环状磁铁的超电流分布，从而场的均匀性；以及4)演示该系统的独特的低温系统：a)将固体霓虹灯和环形磁铁的体积保持在15K的标称工作温度；B)在装运通电磁铁时，使通电的环形磁铁在无制冷机的“冷却空白期”(约48小时)期间，在15-24K的范围内保持其持久模场，或在需要时运行，以提供无振动的测量环境。我们的“高场台式”环形核磁共振磁体允许对其他原子核进行测量，例如23Na、39K(而不是1H)，对于这些原子核，“低场台式”核磁共振磁体的信号灵敏度是不够的。这个分两个阶段的计划的意义在于，它将导致一种新型的持续模式、高分辨率的“微线圈”核磁共振磁体，其中紧凑、简单的制造和易于操作是磁体的关键特征。这三个特征对于在制药和食品行业广泛使用药物和食品来发现和开发药物和食品至关重要；甚至可能在大约15年内被医生作为一种新的办公室工具，为患者提供有效的医疗护理。我们预计环形磁铁将具有成本效益，再加上其紧凑性，它应该会成为核磁共振磁铁行业及时毫无疑问地接受的一项新技术：我们相信，这就是这项新的环形磁铁技术的终极意义。已经向包括诺华和辉瑞在内的最终用户介绍了拟议的系统；他们的反应非常积极。

The specific aims of this Phase 1 of a 2-Phase program to design, manufacture, and operate a prototype 200MHz/38mm “bench-top” NMR “annulus" magnet (in Phase 2: 300MHz/43mm and 500MHz/43mm magnets) are four-fold: 1) Design, manufacture, and operation of a 200MHz/38mm bore prototype "NMR-class'' magnet based on an innovative design/operation concept that is particularly suited to a new type of persistent-mode NMR magnets for high-resolution "micro-NMR" spectroscopy; 2) Demonstrate, with the prototype, the unique feature of the annulus magnet that permits the magnet to be energized at one site (manufacturer) and transported to another site (user), while the magnet maintains its NMR-quality magnetic field; 3) Complete and demonstrate a "fieldtweaking'' technique that permits "micro-tuning" of the supercurrent distributions of annuli and hence the field homogeneity; and 4) Demonstrate the system's unique cryogenic system that: a) keeps a volume of solid neon and the annulus magnet at a nominal operating temperature of 15 K; b) enables the energized annulus magnet to maintain its persistent-mode field over the range 15-24K during a cryocooler-free "cooling-blank" period (~48 hours), when the energized magnet is shipped, or, if required, operated to provide a vibration-free environment for measurement. Our "high-field benchtop" annulus NMR magnet permits measurement with other nuclei, e.g., 23Na, 39K (rather than 1H), for which signal sensitivities are not sufficient with a "low-field bench-top" NMR magnet. The significance of this 2-phase program is that it would lead to a new type of persistent-mode, high-resolution “microcoil” NMR magnets, in which compactness, simple manufacturability, and ease of operation are the magnet's key features. The three features are vital for a widespread use in pharmaceutical and food industries for discovery and development of drugs and foods; even potentially, perhaps in ~15 years, by medical doctors as a new in-office tool for efficient medical care of patients. We expect the annulus magnet to be cost-effective, and combined with its compactness, it should become a new technology that the NMR magnet industry will in time unquestionably embrace: this, we believe, is the ultimate significance of this new annulus magnet technology. The proposed system has been described to the ultimate users, including those at Novartis and Pfizer; their responses have been highly positive.