Biomaterials that Prevent Biofilm Colonization and Device-based Infections

防止生物膜定植和设备感染的生物材料

• 批准号: 7582522
• 负责人: James D. Bryers
• 金额: $ 37.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7582522
• 关键词: 2-hydroxyethyl methacrylate; Adhesions; Antibiotic Resistance; Antibiotics; Bacteria; Biocompatible Materials; Biological Assay; Biomedical Engineering; Blood capillaries; Cell Survival; Cells; Chimeric Proteins; Chronic; Ciprofloxacin; Clinical; Complex; Control Groups; Devices; Drug Controls; Drug Formulations; Endothelial Cells; Exhibits; Foreign Bodies; Foreign-Body Giant Cells; Gallium; Generic Drugs; Growth; Healed; Hydrogels; Immune response; Implant; In Vitro; Infection; Inflammation; Iron; Medical; Medical Device; Microbial Biofilms; Modeling; Mus; Nosocomial Infections; Opsonin; Pathogenesis; Performance; Phagocytosis; Prosthesis; Pseudomonas aeruginosa; Research Project Grants; Series; Siderophores; Staphylococcus epidermidis; Suspension Culture; Technology; Testing; Work; Wound Healing; analog; angiogenesis; base; capillary; capsule; controlled release; cytokine; density; design; design and construction; fluid flow; healing; in vivo; iron metabolism; macrophage; microbial; new technology; poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer; prevent; response; tissue regeneration

DESCRIPTION (provided by applicant): In this 5-yr Bioengineering Research Grant (BRG), we will develop a class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections. Our group comprises experts in biomaterials synthesis and characterization, controlled drug release, inflammation and immune response, biofilm dynamics, microbial pathogenesis, and antibiotic resistance. Collectively, our group will deliver to clinical reality new technologies that will prevent biofilm formation and/or disrupt existing medical biofilms. Specific aims of this BRG will be the following: Aim 1. Develop porous "templated" constructs (PTCs) that promote healing while preventing bacterial biofilm formation. Aim 2. Quantify, in vitro, the efficacy of various PTCs to promote healing while preventing bacterial colonization. Aim 3. Quantify, in vivo, the efficacy of the PTCs optimized in Aim 2 to promote healing and prevent biofilm colonization. It is estimated that over 5 million artificial or prosthetic devices are implanted per annum in the U.S. alone. However, 70% of hospital-acquired infections are associated with implants or indwelling medical devices, with the case-to-fatality ratio between 5-50%. In this 5-yr Bioengineering Research Grant (BRG), we will develop a class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections.

描述（由申请人提供）：在这项为期5年的生物工程研究资助（BRG）中，我们将开发一类生物材料，促进愈合，同时防止细菌定植和随后的感染。我们的团队由生物材料合成和表征、药物控释、炎症和免疫反应、生物膜动力学、微生物发病机制和抗生素耐药性方面的专家组成。总的来说，我们的团队将为临床实践提供新技术，以防止生物膜形成和/或破坏现有的医学生物膜。该BRG的具体目标如下：目标1。开发多孔“模板”结构（PTC），促进愈合，同时防止细菌生物膜形成。目标二。在体外定量各种PTC促进愈合同时防止细菌定植的功效。目标3.在体内定量在目标2中优化的PTC促进愈合和防止生物膜定殖的功效。据估计，仅在美国，每年就有超过500万件人工或假体装置被植入。然而，70%的医院获得性感染与植入物或留置医疗器械有关，病死率在5- 50%之间。在这项为期5年的生物工程研究资助（BRG）中，我们将开发一类促进愈合同时防止细菌定植和后续感染的生物材料。