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Metal-titanates as Novel Inhibitors of Cariogenic Biofilms at Tooth-composite Int

金属钛酸盐作为牙齿复合材料国际中心致龋生物膜的新型抑制剂

基本信息

批准号：
8509661
负责人：
James D. Bryers
金额：
$ 36.41万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-10 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8509661
关键词：
3-Dimensional Affect Anti-Bacterial Agents Area Bacteria Biological Process Bioreactors Ceramics Characteristics Communities Complex Composite Resins Computer software Data Dental Bonding Dental Enamel Dental caries Dentin Fatigue Filler Funding Goals Growth Human Volunteers In Situ In Vitro Infection Investigation Ion Exchange Ions Knowledge Laboratories Laser Microscopy Lesion Longevity Mechanics Metabolism Metals Microbe Microbial Biofilms Modeling Monoclonal Antibodies Morphology Nature Optics Oral Outcome Particle Size Plant Resins Population Distributions Population Dynamics Process Property Quantum Dots Reporting Reproducibility Research Research Personnel Resource Sharing Structure Surface Techniques Tooth structure United States National Institutes of Health Work absorption antibody conjugate antimicrobial cariogenic bacteria composite restoration human subject improved in vivo inhibitor/antagonist innovation metal complex microbial microleakage multi-photon multidisciplinary nanoparticle novel physical process physical property public health relevance restoration

项目摘要

DESCRIPTION (provided by applicant): Our goal of this investigation is to develop a new class of antibacterial nanoparticle titanate-metal complexes. Micro titanate-metal complexes have been shown to have antimicrobial activity. At present, there are no data on the interactions of nanoparticle titanate with bacteria and on the antibacterial properties of metal ions of Au(III), Pd(II), and Pt(IV). The central hypothesis of this investigation is that nanoparticle titanate-metal complexes that are incorporated into a dental bonding resin will inhibit cariogenic bacterial growth in a biofilm adjacent to the tooth/composite restoration interface without compromising resin-tooth bonding. The proposed work is innovative, because it capitalizes on a new class of titanate-metal complexes as antibacterial agents. In addition, biofilm population dynamics with respect to tooth/composite restoration interface will be quantified non-invasively by Mab-conjugated quantum dots. There are only three such reports on bacterial biofilms and none applied to cariogenic bacteria. The combination of the work proposed is expected to allow the clinicians to tackle the composite longevity problem at the weakest interface. By exploring the interactions between titanate-metal complexes and bacteria biofilm, we will bridge a major gap in knowledge about a new class of titanate-metal complexes antibacterials. PUBLIC HEALTH RELEVANCE: Our investigation will develop a new class of antibacterial nanoparticle titanate-metal complexes of Au(III), Pd(II), and Pt(IV). We will incorporate this titanate-metal complexes into a dental bonding resin, which will inhibit cariogenic bacterial growth in a biofilm adjacent to the tooth/composite restoration interface. We will study the biofilm collected both in the laboratory and from human subjects with multi-photon laser microscopy.

描述（由申请人提供）：我们的研究目标是开发一类新型抗菌纳米钛酸盐金属配合物。微钛酸-金属配合物已被证明具有抗菌活性。目前，纳米钛酸颗粒与细菌的相互作用以及Au（III）、Pd（II）和Pt（IV）金属离子的抑菌性能尚无相关数据。本研究的中心假设是，纳米钛酸金属配合物被纳入牙齿粘合树脂中，可以抑制牙齿/复合修复界面附近生物膜中的蛀牙细菌生长，而不会影响树脂-牙齿粘合。提出的工作是创新的，因为它利用了一类新的钛酸-金属配合物作为抗菌剂。此外，关于牙齿/复合修复界面的生物膜种群动态将通过单克隆抗体共轭量子点进行无创量化。目前仅有三篇关于细菌生物膜的报道，没有一篇是关于龋齿细菌的。所提出的工作组合有望使临床医生在最薄弱的界面上解决复合寿命问题。通过探索钛酸盐-金属配合物与细菌生物膜之间的相互作用，我们将弥补对一类新型钛酸盐-金属配合物抗菌剂的认识上的重大空白。