Metal-titanates as Novel Inhibitors of Cariogenic Biofilms at Tooth-composite Int
金属钛酸盐作为牙齿复合材料国际中心致龋生物膜的新型抑制剂
基本信息
- 批准号:8509661
- 负责人:
- 金额:$ 36.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-10 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAffectAnti-Bacterial AgentsAreaBacteriaBiological ProcessBioreactorsCeramicsCharacteristicsCommunitiesComplexComposite ResinsComputer softwareDataDental BondingDental EnamelDental cariesDentinFatigueFillerFundingGoalsGrowthHuman VolunteersIn SituIn VitroInfectionInvestigationIon ExchangeIonsKnowledgeLaboratoriesLaser MicroscopyLesionLongevityMechanicsMetabolismMetalsMicrobeMicrobial BiofilmsModelingMonoclonal AntibodiesMorphologyNatureOpticsOralOutcomeParticle SizePlant ResinsPopulation DistributionsPopulation DynamicsProcessPropertyQuantum DotsReportingReproducibilityResearchResearch PersonnelResource SharingStructureSurfaceTechniquesTooth structureUnited States National Institutes of HealthWorkabsorptionantibody conjugateantimicrobialcariogenic bacteriacomposite restorationhuman subjectimprovedin vivoinhibitor/antagonistinnovationmetal complexmicrobialmicroleakagemulti-photonmultidisciplinarynanoparticlenovelphysical processphysical propertypublic health relevancerestoration
项目摘要
DESCRIPTION (provided by applicant): Our goal of this investigation is to develop a new class of antibacterial nanoparticle titanate-metal complexes. Micro titanate-metal complexes have been shown to have antimicrobial activity. At present, there are no data on the interactions of nanoparticle titanate with bacteria and on the antibacterial properties of metal ions of Au(III), Pd(II), and Pt(IV). The central hypothesis of this investigation is that nanoparticle titanate-metal complexes that are incorporated into a dental bonding resin will inhibit cariogenic bacterial growth in a biofilm adjacent to the tooth/composite restoration interface without compromising resin-tooth bonding. The proposed work is innovative, because it capitalizes on a new class of titanate-metal complexes as antibacterial agents. In addition, biofilm population dynamics with respect to tooth/composite restoration interface will be quantified non-invasively by Mab-conjugated quantum dots. There are only three such reports on bacterial biofilms and none applied to cariogenic bacteria. The combination of the work proposed is expected to allow the clinicians to tackle the composite longevity problem at the weakest interface. By exploring the interactions between titanate-metal complexes and bacteria biofilm, we will bridge a major gap in knowledge about a new class of titanate-metal complexes antibacterials.
PUBLIC HEALTH RELEVANCE: Our investigation will develop a new class of antibacterial nanoparticle titanate-metal complexes of Au(III), Pd(II), and Pt(IV). We will incorporate this titanate-metal complexes into a dental bonding resin, which will inhibit cariogenic bacterial growth in a biofilm adjacent to the tooth/composite restoration interface. We will study the biofilm collected both in the laboratory and from human subjects with multi-photon laser microscopy.
描述(由申请人提供):我们的研究目标是开发一类新型抗菌纳米钛酸盐金属配合物。微钛酸-金属配合物已被证明具有抗菌活性。目前,纳米钛酸颗粒与细菌的相互作用以及Au(III)、Pd(II)和Pt(IV)金属离子的抑菌性能尚无相关数据。本研究的中心假设是,纳米钛酸金属配合物被纳入牙齿粘合树脂中,可以抑制牙齿/复合修复界面附近生物膜中的蛀牙细菌生长,而不会影响树脂-牙齿粘合。提出的工作是创新的,因为它利用了一类新的钛酸-金属配合物作为抗菌剂。此外,关于牙齿/复合修复界面的生物膜种群动态将通过单克隆抗体共轭量子点进行无创量化。目前仅有三篇关于细菌生物膜的报道,没有一篇是关于龋齿细菌的。所提出的工作组合有望使临床医生在最薄弱的界面上解决复合寿命问题。通过探索钛酸盐-金属配合物与细菌生物膜之间的相互作用,我们将弥补对一类新型钛酸盐-金属配合物抗菌剂的认识上的重大空白。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Titanates and Titanate-Metal Compounds in Biological Contexts.
- DOI:10.23937/2378-3664/1410009
- 发表时间:2015
- 期刊:
- 影响因子:0
- 作者:Yen-Wei Chen;Jeanie L. Drury;W. Chung;D. Hobbs;J. Wataha
- 通讯作者:Yen-Wei Chen;Jeanie L. Drury;W. Chung;D. Hobbs;J. Wataha
Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate.
纳米钛酸钠的合成和反应化学。
- DOI:10.3791/53248
- 发表时间:2016
- 期刊:
- 影响因子:0
- 作者:Elvington,MarkC;Taylor-Pashow,KathrynML;Tosten,MichaelH;Hobbs,DavidT
- 通讯作者:Hobbs,DavidT
Antibacterial activity of gold-titanates on Gram-positive cariogenic bacteria.
- DOI:10.3109/23337931.2015.1084883
- 发表时间:2015-12-01
- 期刊:
- 影响因子:0
- 作者:Eiampongpaiboon, Trinuch;Chung, Whasun O;Chan, Daniel C N
- 通讯作者:Chan, Daniel C N
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James D. Bryers其他文献
James D. Bryers的其他文献
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{{ truncateString('James D. Bryers', 18)}}的其他基金
Injectable Hydrogel Depots for Self-replicating mRNA Vaccine Delivery
用于自我复制 mRNA 疫苗递送的可注射水凝胶库
- 批准号:
10664048 - 财政年份:2022
- 资助金额:
$ 36.41万 - 项目类别:
Injectable Hydrogel Depots for Self-replicating mRNA Vaccine Delivery
用于自我复制 mRNA 疫苗递送的可注射水凝胶库
- 批准号:
10438409 - 财政年份:2022
- 资助金额:
$ 36.41万 - 项目类别:
Tissue Regeneration by Engineered Extracellular Vesicles
工程细胞外囊泡的组织再生
- 批准号:
10021673 - 财政年份:2019
- 资助金额:
$ 36.41万 - 项目类别:
Tissue Regeneration by Engineered Extracellular Vesicles
工程细胞外囊泡的组织再生
- 批准号:
10456835 - 财政年份:2019
- 资助金额:
$ 36.41万 - 项目类别:
Tissue Regeneration by Engineered Extracellular Vesicles
工程细胞外囊泡的组织再生
- 批准号:
10218210 - 财政年份:2019
- 资助金额:
$ 36.41万 - 项目类别:
Metal-titanates as Novel Inhibitors of Cariogenic Biofilms at Tooth-composite Int
金属钛酸盐作为牙齿复合材料国际中心致龋生物膜的新型抑制剂
- 批准号:
8304138 - 财政年份:2010
- 资助金额:
$ 36.41万 - 项目类别:
Metal-titanates as Novel Inhibitors of Cariogenic Biofilms at Tooth-composite Int
金属钛酸盐作为牙齿复合材料国际中心致龋生物膜的新型抑制剂
- 批准号:
8141302 - 财政年份:2010
- 资助金额:
$ 36.41万 - 项目类别:
Resolving Biomaterial Inflammatory Response by Controlling Macrophage Phenotype
通过控制巨噬细胞表型解决生物材料炎症反应
- 批准号:
8140775 - 财政年份:2010
- 资助金额:
$ 36.41万 - 项目类别:
Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
具有 BITE(通过 T 细胞增强的生物膜免疫)的牙周生物材料
- 批准号:
7934229 - 财政年份:2010
- 资助金额:
$ 36.41万 - 项目类别:
Effects of Shear on Specific Adhesion Receptor Expression and Binding in the Bact
剪切对细菌中特异性粘附受体表达和结合的影响
- 批准号:
7860401 - 财政年份:2009
- 资助金额:
$ 36.41万 - 项目类别:
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