Biomaterials that Prevent Biofilm Colonization and Device-based Infections

防止生物膜定植和设备感染的生物材料

• 批准号: 8271373
• 负责人: James D. Bryers
• 金额: $ 43.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-01-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8271373
• 关键词: 2-hydroxyethyl methacrylate; Adhesions; American; Antibiotic Resistance; Antibiotic Therapy; Antibiotics; Artificial Heart; Artificial cardiac pacemaker; Bacteria; Binding; Biocompatible Materials; Biological Assay; Biomedical Engineering; Blood Vessel Prosthesis; Blood capillaries; Catheters; Cause of Death; Cell Survival; Cells; Cerebrospinal fluid shunts procedure; Cessation of life; Chimeric Proteins; Chronic; Ciprofloxacin; Clinical; Complex; Contact Lenses; Control Groups; Device Removal; Devices; Dose; Drug Controls; Drug Formulations; Endothelial Cells; Exhibits; Foreign Bodies; Foreign-Body Giant Cells; Gallium; Generic Drugs; Growth; Healed; Heart Valve Prosthesis; Hospitals; Hydrogels; Immune response; Implant; In Vitro; Infection; Inflammation; Intrauterine Devices; Iron; Left; Medical; Medical Device; Microbial Biofilms; Modeling; Mus; Nosocomial Infections; Ocular Prosthesis; Opsonin; Organism; Orthopedics; Pathogenesis; Patients; Performance; Phagocytosis; Prosthesis; Pseudomonas aeruginosa; Research Project Grants; Resistance development; Risk; Series; Siderophores; Staphylococcus epidermidis; Suspension Culture; Technology; Testing; Work; Wound Healing; analog; angiogenesis; antimicrobial; base; capillary; capsule; controlled release; cost; cytokine; density; design; design and construction; fluid flow; healing; in vivo; iron metabolism; killings; macrophage; microbial; new technology; poly(2-hydroxyethyl methacrylate)-polyamine graft copolymer; prevent; response; stressor; tissue regeneration; urinary; ventricular assist device

DESCRIPTION (provided by applicant): In this 5-yr Bioengineering Research Grant (BRG), we will develop a class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections. Our group comprises experts in biomaterials synthesis and characterization, controlled drug release, inflammation and immune response, biofilm dynamics, microbial pathogenesis, and antibiotic resistance. Collectively, our group will deliver to clinical reality new technologies that will prevent biofilm formation and/or disrupt existing medical biofilms. Specific aims of this BRG will be the following: Aim 1. Develop porous "templated" constructs (PTCs) that promote healing while preventing bacterial biofilm formation. Aim 2. Quantify, in vitro, the efficacy of various PTCs to promote healing while preventing bacterial colonization. Aim 3. Quantify, in vivo, the efficacy of the PTCs optimized in Aim 2 to promote healing and prevent biofilm colonization. It is estimated that over 5 million artificial or prosthetic devices are implanted per annum in the U.S. alone. However, 70% of hospital-acquired infections are associated with implants or indwelling medical devices, with the case-to-fatality ratio between 5-50%. In this 5-yr Bioengineering Research Grant (BRG), we will develop a class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections.

描述（由申请人提供）：在这项为期5年的生物工程研究资助（BRG）中，我们将开发一类促进愈合同时防止细菌定植和随后感染的生物材料。我们的团队由生物材料合成和表征、药物控制释放、炎症和免疫反应、生物膜动力学、微生物发病机制和抗生素耐药性方面的专家组成。总的来说，我们的团队将为临床现实提供新技术，以防止生物膜的形成和/或破坏现有的医学生物膜。该小组的具体目标如下：目标1。开发多孔“模板”结构（ptc），促进愈合，同时防止细菌生物膜的形成。目标2。量化，在体外，各种ptc促进愈合的功效，同时防止细菌定植。目标3。在体内量化Aim 2中优化的ptc在促进愈合和防止生物膜定植方面的功效。据估计，仅在美国，每年就有超过500万个人工或假体装置被植入。然而，70%的医院获得性感染与植入物或留置医疗器械有关，病死率在5-50%之间。在这项为期5年的生物工程研究资助（BRG）中，我们将开发一类促进愈合的生物材料，同时防止细菌定植和随后的感染。

项目成果

Development of a poly(ether urethane) system for the controlled release of two novel anti-biofilm agents based on gallium or zinc and its efficacy to prevent bacterial biofilm formation.

• DOI: 10.1016/j.jconrel.2013.10.005
• 发表时间: 2013-12-28
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Ma H;Darmawan ET;Zhang M;Zhang L;Bryers JD
• 通讯作者: Bryers JD

Non-invasive in situ monitoring and quantification of TOL plasmid segregational loss within Pseudomonas putida biofilms.

• DOI: 10.1002/bit.24953
• 发表时间: 2013-11
• 期刊: Biotechnology and bioengineering
• 影响因子: 3.8
• 作者: Ma H;Katzenmeyer KN;Bryers JD
• 通讯作者: Bryers JD

Antimicrobial effects of nanofiber poly(caprolactone) tissue scaffolds releasing rifampicin.

• DOI: 10.1007/s10856-012-4609-3
• 发表时间: 2012-06
• 期刊: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
• 影响因子: 3.7
• 作者: Ruckh, Timothy T.;Oldinski, Rachael A.;Carroll, Derek A.;Mikhova, Krasimira;Bryers, James D.;Popat, Ketul C.
• 通讯作者: Popat, Ketul C.

Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts.

• DOI: 10.1002/bit.24559
• 发表时间: 2012-08
• 期刊: BIOTECHNOLOGY AND BIOENGINEERING
• 影响因子: 3.8
• 作者: Bryers, James D.;Giachelli, Cecilia M.;Ratner, Buddy D.
• 通讯作者: Ratner, Buddy D.

Sustained release of antibiotic from poly(2-hydroxyethyl methacrylate) to prevent blinding infections after cataract surgery.

• DOI: 10.1016/j.biomaterials.2009.06.047
• 发表时间: 2009-10
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Anderson, Erin M.;Noble, Misty L.;Garty, Shai;Ma, Hongyan;Bryers, James D.;Shen, Tueng T.;Ratner, Buddy D.
• 通讯作者: Ratner, Buddy D.