Biomaterials that Prevent Biofilm Colonization and Device-based Infections

描述(申请人提供)：在这项为期5年的生物工程研究资助(BRG)中，我们将开发一类促进愈合的生物材料，同时防止细菌定植和后续感染。我们的团队由生物材料合成和表征、受控药物释放、炎症和免疫反应、生物膜动力学、微生物发病机制和抗生素耐药性方面的专家组成。我们的团队将共同为临床提供新的技术，以防止生物膜的形成和/或破坏现有的医学生物膜。这一BRG的具体目标如下：目标1.开发多孔的“模板化”结构(PTCs)，促进愈合，同时防止细菌生物膜的形成。目的2.在体外量化各种PTCs在促进愈合的同时防止细菌定植的效果。目的3.在体内量化目标2中优化的PTCs促进愈合和防止生物被膜定植的效果。据估计，仅在美国，每年就有超过500万台人工或假肢装置被植入。然而，70%的医院获得性感染与植入物或留置医疗器械有关，病死率在5-50%之间。在这项为期5年的生物工程研究奖助金(BRG)中，我们将开发一类促进愈合的生物材料，同时防止细菌定植和随后的感染。

DESCRIPTION (provided by applicant): In this 5-yr Bioengineering Research Grant (BRG), we will develop a class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections. Our group comprises experts in biomaterials synthesis and characterization, controlled drug release, inflammation and immune response, biofilm dynamics, microbial pathogenesis, and antibiotic resistance. Collectively, our group will deliver to clinical reality new technologies that will prevent biofilm formation and/or disrupt existing medical biofilms. Specific aims of this BRG will be the following: Aim 1. Develop porous "templated" constructs (PTCs) that promote healing while preventing bacterial biofilm formation. Aim 2. Quantify, in vitro, the efficacy of various PTCs to promote healing while preventing bacterial colonization. Aim 3. Quantify, in vivo, the efficacy of the PTCs optimized in Aim 2 to promote healing and prevent biofilm colonization. It is estimated that over 5 million artificial or prosthetic devices are implanted per annum in the U.S. alone. However, 70% of hospital-acquired infections are associated with implants or indwelling medical devices, with the case-to-fatality ratio between 5-50%. In this 5-yr Bioengineering Research Grant (BRG), we will develop a class of biomaterials that promote healing while preventing bacterial colonization and subsequent infections.