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Inflammatory mechanisms in the toxicity of ricin

Inflammatory mechanisms in the toxicity of ricin
蓖麻毒素毒性的炎症机制
批准号：
8084854
负责人：
BRUCE E. MAGUN
金额：
$38.5万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-06-21 至 2011-05-31
来源：
https://reporter.nih.gov/project-details/8084854
关键词：
AcuteAdenineAerosolsAlveolar MacrophagesAntibodiesApoptosisBiologicalBioterrorismBone MarrowBreathingCaspase-1Cell DeathCellsCessation of lifeComplexDepurinationDevelopmentEdemaEnvironmentEventGene ExpressionGenesGenetic TranscriptionGoalsHumanImmunoprecipitationInflammationInflammation MediatorsInflammatoryInflammatory ResponseInjuryInterleukin-1Interleukin-1 ReceptorsLeadLifeLungLung InflammationMAP Kinase GeneMAPK14 geneMAPK8 geneMass Spectrum AnalysisMeasuresMediatingMediator of activation proteinMolecularMolecular Sieve ChromatographyMolecular TargetMusNADPH OxidasePathologyPathway interactionsPhosphorylationPhosphotransferasesPneumoniaPopulationProcessProductionProteasome InhibitorProtein InhibitionProtein Synthesis InhibitorsProteinsProteomicsPublishingRNA, Ribosomal, 28SReactive Oxygen SpeciesResearchResidual stateRicinRoleSignal PathwaySignal TransductionTestingTherapeuticToxic effectToxinTransducersTranslationsaerosolizedanakinrachemokinecytokineefficacy testingextracellularin vivoinhibitor/antagonistlung injurymacrophagemortalityneutrophilnovelpathogenreceptorresponsesecretion processstemstress activated protein kinaseupstream kinase

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