Cancer Biology

癌症生物学

• 批准号: 7107585
• 负责人: BRUCE E. MAGUN
• 金额: $ 0.96万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-05 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7107585
• 关键词: biological signal transduction; carcinogenesis; cell biology; gene expression; neoplasm /cancer genetics; neoplastic process

The Cancer Biology program constitutes the foundation of basic science research of the OHSU Cancer institute. The overall goal of the Cancer Biology Program is to investigate the underlying cellular and molecular mechanisms involved in the development of cancer and in the regulation of both normal and abnormal cell growth. The scientific thrust of the program is in two related areas of investigation: Carcinogenesis/Genetic Instability and Signal Transduction. There are with 34 full and 2 associate members in the program with $25.1 million in grant funding stemming from 83 projects. Of these, 26 grants provide $7.4 million in NCI funding. Members of the Carcinogenesis/Genetic Instability group focus their studies around cell cycle control, the regulation of apoptosis, and the relationship of these events to the development of genetic instability and cancer. The members of the Signal Transduction group focus their studies around general signaling mechanisms of relevance to regulation of normal and cancer cell growth: the integrated function of growth factors and their receptors, kinase-mediated signaling phenomena, and the regulation of transcription that lies downstream of the aforementioned events. Because of the seamless nature of cellular regulation that is relevant to the cancer problem, there is a great deal of overlap between the research interests of the two groups. These shared interests have led to an abundance of collaborations and interactivity among the members of the Cancer Biology program.

癌症生物学项目构成了OHSU癌症研究所基础科学研究的基础。癌症生物学计划的总体目标是研究癌症发生的潜在细胞和分子机制，以及调节正常和异常细胞生长的机制。该计划的科学主旨是在两个相关的研究领域：癌症发生/遗传不稳定性和信号转导。该计划有34个正式成员和2个准成员，提供2510万美元的赠款资金 来自83个项目。其中，26项赠款提供了740万美元的NCI资金。癌症发生/遗传不稳定小组的成员主要围绕细胞周期控制、细胞凋亡的调节以及这些事件与遗传不稳定和癌症的发展的关系进行研究。信号转导小组的成员主要围绕与正常和癌细胞生长调控相关的一般信号机制进行研究：生长因子及其受体的整合功能，激酶介导的信号现象，以及上述事件下游的转录调控。由于与癌症问题相关的细胞调节的无缝性质，这两组人的研究兴趣有很大的重叠。这些共同的兴趣导致了癌症生物学项目成员之间的大量合作和互动。