High Throughput Screening for Advanced Scintillation Detectors

先进闪烁探测器的高通量筛选

• 批准号: 7798284
• 负责人: xiao-dong sun
• 金额: $ 36.78万
• 依托单位: SUN INNOVATIONS COMPANY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-11 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7798284
• 关键词: Angiography; Arts; Cardiovascular system; Cerium; Collection; Combinatorial Synthesis; Computers; Deposition; Detection; Diagnosis; Diagnostic radiologic examination; Disease; Elements; Emission-Computed Tomography; Eye; Future Generations; Heavy Metals; Image; Laboratories; Libraries; Library Materials; Life; Light; Lutetium; Mammography; Medical; Medical Imaging; Oxides; Performance; Phase; Photons; Positron-Emission Tomography; Process; Property; Sampling; Screening procedure; Small Business Innovation Research Grant; Staging; System; Techniques; Time; Work; X-Ray Computed Tomography; base; combinatorial; cost; density; design; detector; high throughput screening; imaging detector; improved; innovation; interest; metal oxide; novel; public health relevance; research and development; tomography; tool; validation studies

DESCRIPTION (provided by applicant): The objective of this SBIR project is to rapidly discover advanced scintillators for applications in many medical imaging detectors, using an efficient combinatorial screening process. In Phase I, we have developed and demonstrated the feasibility on a set of novel combinatorial screening tools, to rapidly synthesize large collection of scintillators in miniature forms, which accurately reproduced the crystalline phases of many well-known scintillators. In Phase II project, the unique set of efficient scintillator R&D tools will be broadly applied to search for advanced Cerium activated heavy metal oxides and halides scintillators. With the set of combinatorial scintillator tools, at least 12,000 different oxides and halides scintillators will be synthesized and characterized in the 2 year project. The specific aim is to discover a new single crystal scintillator phase with superior luminosity, faster fluorescent decay time, and lower material cost than state-of-the-art medical detector scintillator, e.g. Lu2SiO5:Ce3+. PUBLIC HEALTH RELEVANCE: Scintillator is a key detector material being used in many major medical diagnosis systems, including radiography, mammography, angiography, cardiovascular and fluoroscopic imaging, computed tomography, single photon emission computed tomography, positron emission tomography, etc. The performance of these medical systems, to a large extent, depends on the properties of scintillators, for example, scintillators with higher luminosity results in more sensitive and accurate detection of diseases at early stages which could save lives. Advanced scintillators that will be discovered in the project will significantly improve many medical imaging detectors.

描述（由申请人提供）：该 SBIR 项目的目标是使用高效的组合筛选过程快速发现适用于许多医学成像探测器的先进闪烁体。在第一阶段，我们开发并论证了一套新颖的组合筛选工具的可行性，以快速合成大量微型闪烁体，准确地再现了许多众所周知的闪烁体的晶相。在二期项目中，一套独特的高效闪烁体研发工具将广泛应用于寻找先进的铈激活重金属氧化物和卤化物闪烁体。通过这套组合闪烁体工具，在为期 2 年的项目中将合成和表征至少 12,000 种不同的氧化物和卤化物闪烁体。具体目标是发现一种新的单晶闪烁体相，与最先进的医疗探测器闪烁体相比，它具有更高的发光度、更快的荧光衰减时间和更低的材料成本。 Lu2SiO5:Ce3+。 公共健康相关性：闪烁体是许多主要医疗诊断系统中使用的关键探测器材料，包括放射线照相、乳房X线照相、血管造影、心血管和荧光镜成像、计算机断层扫描、单光子发射计算机断层扫描、正电子发射断层扫描等。这些医疗系统的性能在很大程度上取决于闪烁体的性能，例如，闪烁体的亮度越高，其灵敏度和灵敏度越高。 早期准确检测疾病可以挽救生命。该项目中将发现的先进闪烁体将显着改进许多医学成像探测器。