High Throughput Screening for Advanced Scintillation Detectors

先进闪烁探测器的高通量筛选

• 批准号: 8043649
• 负责人: xiao-dong sun
• 金额: $ 37.28万
• 依托单位: SUN INNOVATIONS COMPANY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-11 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8043649
• 关键词: Angiography; Cardiovascular system; Cerium; Collection; Combinatorial Synthesis; Computers; Deposition; Detection; Diagnosis; Diagnostic radiologic examination; Disease; Elements; Emission-Computed Tomography; Eye; Future Generations; Heavy Metals; Image; Laboratories; Libraries; Library Materials; Light; Lutetium; Mammography; Medical; Medical Imaging; Oxides; Performance; Phase; Photons; Positron-Emission Tomography; Process; Property; Sampling; Screening procedure; Small Business Innovation Research Grant; Staging; System; Techniques; Time; Work; X-Ray Computed Tomography; base; combinatorial; cost; density; design; detector; high throughput screening; imaging detector; improved; innovation; interest; metal oxide; novel; public health relevance; research and development; tomography; tool; validation studies

DESCRIPTION (provided by applicant): The objective of this SBIR project is to rapidly discover advanced scintillators for applications in many medical imaging detectors, using an efficient combinatorial screening process. In Phase I, we have developed and demonstrated the feasibility on a set of novel combinatorial screening tools, to rapidly synthesize large collection of scintillators in miniature forms, which accurately reproduced the crystalline phases of many well-known scintillators. In Phase II project, the unique set of efficient scintillator R&D tools will be broadly applied to search for advanced Cerium activated heavy metal oxides and halides scintillators. With the set of combinatorial scintillator tools, at least 12,000 different oxides and halides scintillators will be synthesized and characterized in the 2 year project. The specific aim is to discover a new single crystal scintillator phase with superior luminosity, faster fluorescent decay time, and lower material cost than state-of-the-art medical detector scintillator, e.g. Lu2SiO5:Ce3+. PUBLIC HEALTH RELEVANCE: Scintillator is a key detector material being used in many major medical diagnosis systems, including radiography, mammography, angiography, cardiovascular and fluoroscopic imaging, computed tomography, single photon emission computed tomography, positron emission tomography, etc. The performance of these medical systems, to a large extent, depends on the properties of scintillators, for example, scintillators with higher luminosity results in more sensitive and accurate detection of diseases at early stages which could save lives. Advanced scintillators that will be discovered in the project will significantly improve many medical imaging detectors.

描述（由申请人提供）：该SBIR项目的目标是使用有效的组合筛选过程，快速发现适用于许多医学成像探测器的高级闪烁器。在第一阶段，我们已经开发并证明了一套新的组合筛选工具的可行性，以快速合成大量的微型形式的结晶剂，这些结晶剂准确地再现了许多知名结晶剂的晶相。在第二期项目中，独特的高效闪烁体研发工具将广泛应用于寻找先进的铈激活重金属氧化物和卤化物闪烁体。利用这套组合闪烁体工具，在为期2年的项目中，将合成和表征至少12，000种不同的氧化物和卤化物闪烁体。具体目标是发现一种新的单晶闪烁体相，其具有比现有技术的医学探测器闪烁体（例如Lu2SiO5：Ce3+）更上级的发光度、更快的荧光衰减时间和更低的材料成本。 公共卫生关系：闪烁体是许多主要医疗诊断系统中使用的关键探测器材料，包括放射照相术、乳房X线照相术、血管造影术、心血管和荧光成像、计算机断层扫描、单光子发射计算机断层扫描、正电子发射断层扫描等。这些医疗系统的性能在很大程度上取决于闪烁体的性质，例如，具有更高亮度的发光器导致在早期阶段更灵敏和准确地检测疾病，从而可以挽救生命。在该项目中发现的先进反射器将显著改善许多医学成像探测器。