Catalysis of Isoniazid action by M. tuberculosis catalase-peroxidase

结核分枝杆菌过氧化氢酶-过氧化物酶对异烟肼作用的催化作用

• 批准号: 8145057
• 负责人: RICHARD S MAGLIOZZO
• 金额: $ 50.94万
• 依托单位: BROOKLYN COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145057
• 关键词: 3-Dimensional; Affect; Affinity; Amino Acids; Antibiotics; Antitubercular Agents; Area; Binding; Binding Sites; Biology; Biomedical Research; Biomimetics; CCL7 gene; Calorimetry; Catalysis; Chemicals; Chemistry; Clinical; Code; Crystallography; Disease; Drug Resistant Tuberculosis; Drug resistance; Electron Spin Resonance Spectroscopy; Electron Transport; Enzymatic Biochemistry; Enzymes; Extreme drug resistant tuberculosis; Failure; Freezing; Funding; Future; Genes; Goals; Health; Heme; Incidence; Infection; Isoniazid resistance; Kinetics; Knowledge; Laboratories; Measurement; Minority; Molecular; Multidrug-Resistant Tuberculosis; Mutation; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Optics; Organism; Pathway interactions; Patients; Peroxidases; Peroxides; Pharmaceutical Preparations; Population Heterogeneity; Postdoctoral Fellow; Prodrugs; Production; Property; Protocols documentation; Public Health; Raman Spectrum Analysis; Reaction; Relative (related person); Research; Research Technics; Resistance; Resistance development; Role; School-Age Population; Scientist; Site; Spectrophotometry; Spectrum Analysis; Structure; Techniques; Therapeutic Agents; Titrations; Tuberculosis; United States National Institutes of Health; X-Ray Crystallography; adduct; analog; bacterial resistance; base; catalase; college; enzyme structure; experience; heme a; high school; improved; insight; isoniazid; killings; mutant; overexpression; oxidation; pathogen; programs; resistant strain; structural biology; tool; tuberculosis treatment

项目成果

Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid.

• DOI: 10.1039/c3cc47022a
• 发表时间: 2013-12-25
• 期刊: Chemical communications (Cambridge, England)
• 作者: Zhao X;Hersleth HP;Zhu J;Andersson KK;Magliozzo RS
• 通讯作者: Magliozzo RS

Molecular details of INH-C10 binding to wt KatG and Its S315T mutant.

INH-C10 与 wt KatG 及其 S315T 突变体结合的分子细节。

• DOI: 10.1021/mp500736n
• 发表时间: 2015
• 期刊: Molecular pharmaceutics
• 影响因子: 4.9
• 作者: Teixeira,VitorH;Ventura,Cristina;Leitão,Ruben;Ràfols,Clara;Bosch,Elisabeth;Martins,Filomena;Machuqueiro,Miguel
• 通讯作者: Machuqueiro,Miguel