Antibacterial, antifungal, antiviral, and antispore paints

抗菌、抗真菌、抗病毒和抗孢子涂料

• 批准号: 8000009
• 负责人: Daniel S ENGEBRETSON
• 金额: $ 8.03万
• 依托单位: PRAIRIE SCIENTIFIC INNOVATIONS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-27 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8000009
• 关键词: Acrylates; Allergic; Allergic Bronchopulmonary Aspergillosis; Amides; Amines; Animal Model; Anti-Bacterial Agents; Antibiotic Resistance; Antifungal Agents; Antiviral Agents; Asthma; Awareness; Bacteria; Binding; Case Study; Cessation of life; Chlorine; Color; Community-Acquired Infections; Corrosives; Coughing; Development; Disinfectants; Drug resistance; Effectiveness; Emulsions; Evaluation; Film; Floods; Floor; Food; Foundations; Free Radicals; Furniture; General Population; Goals; Gram-Negative Bacteria; Gram-Positive Bacteria; Growth; Halogenated Hydrocarbons; Halogens; Health; Health Care Costs; Health care facility; Healthcare; Home environment; Hour; Hypochlorite; Imides; Immunocompromised Host; Individual; Industry; Infection; Iodine; Ions; Latex; Marketing; Molds; Monitor; Multi-Drug Resistance; Mus; Natural regeneration; Nitrogen; Obstruction; Odors; Paint; Performance; Phase; Plastics; Play; Population; Potassium; Prisons; Problem Solving; Reporting; Reproduction spores; Research; Resistance; Rhinitis; Risk; Role; Schools; Silver; Simulate; Sinusitis; Small Business Technology Transfer Research; Soil; Sports; Spottings; Starch; Structure; Surface; Symptoms; Techniques; Technology; Telephone; Testing; Textiles; Touch sensation; Triclosan; Upper respiratory tract; Vancomycin resistant enterococcus; Virus; Water; Wheezing; Work; Zinc; antimicrobial; base; biomaterial compatibility; calcium hydroxide; chlorination; cost; covalent bond; design; fungus; high risk; improved; innovation; killings; methicillin resistant Staphylococcus aureus; microbial; microorganism; monomer; new technology; novel; novel strategies; pathogen; phase 1 study; phase 2 study; physical property; polymerization; public health relevance; quaternary ammonium compound; titanium dioxide; transmission process; trend

DESCRIPTION (provided by applicant): There is a fast growing need for antimicrobial paints and coatings to improve microbial quality in residential, commercial, institutional, and industrial applications so as to control the growth of mold and/or reduce the risk of healthcare-associated infections or community-acquired infections. A number of paint products on the market claim "antimicrobial" functions. However, the current products have significant shortfalls, including weak antimicrobial activities, risk of microbial resistance, and difficulty in monitoring and extending the antimicrobial functions once the paints are applied. To solve these problems, in this proposed project, we will use polymeric N-halamines, a class of widely used water and food disinfectants, as antimicrobial additives to provide biocidal effects against bacteria (including drug-resistant species), mold and other fungi species, viruses, and spores. An N-halamine is a compound containing one or more nitrogen-halogen covalent bonds. N-halamines have similar antimicrobial efficacy as hypochlorite bleach, but they are much more stable, none corrosive, with no reported cases of microbial resistance, and have a much less tendency to generate halogenated hydrocarbons. In our technology, a new N-halamine monomer developed in our lab, N-chloro-2,2,6,6- tetramethyl-4-piperidinyl acrylate (Cl-TMPA), will be polymerized to produce polymeric N-halamine latex emulsions. On adding a small amount of such emulsions into conventional water-based latex paint, the new paint will be able to provide potent antimicrobial activities against various microorganisms. The antimicrobial activity is anticipated to last for the lifetime of the paint under normal use. Challenging conditions (e.g., heavy soil, flooding, etc.) may consume more chlorine and thus shorten the antimicrobial duration. Nevertheless, the antimicrobial function of the new paints can be easily monitored by a simple potassium iodine/starch test. That is, polymeric N-halmines will react with potassium iodine to generate a dark blue color with starch. Thus, this test determines whether the paint still provides antimicrobial functions. If it shows that the antimicrobial function is lost, the polymeric N-halamine structures can be resumed by wiping the surface with diluted hypochlorite bleach to recharge the lost chlorine and regenerate the antimicrobial functions. The recharging can be repeated as needed. If successful, this technology will provide an innovative approach to protect high-touch, high-risk surfaces in a wide range of applications, which will have a broad and significant impact on health. This STTR Phase I study is designed to establish the feasibility and effectiveness of the new approach before continuation and expansion of the project. The specific aims of the proposed research are to: (1) create polymeric N-halamine latex emulsions; (2) mix the polymeric N-halamine latex emulsions with commercially important latex paints, and characterize the physical properties, antimicrobial performance, and biocompatibility of the new paints developed; and (3) preliminarily determine the cost of the new approach. PUBLIC HEALTH RELEVANCE: The unique features of the new paints include the broad antimicrobial spectrum against bacteria, mold and other fungi species, viruses, and spores, the ease in monitoring the antimicrobial activity, the rechargability of N-halamines if the antimicrobial function is accidentally lost, and the low risk of microbial resistance. These advantages make the new polymeric N-halamine-based antimicrobial paints an attractive candidate for protecting high-touch, high-risk surfaces in residential, commercial, institutional, industrial, and other related facilities. This STTR Phase I research will serve as the foundation for continuation and expansion of the project and finally commercialize the products to improve the microbial quality of a wide range of environmental surfaces, and this will have a broad and significant impact on health.

描述（由申请人提供）：对抗菌油漆和涂料的需求快速增长，以改善住宅、商业、机构和工业应用中的微生物质量，从而控制霉菌的生长和/或降低医疗保健相关感染或社区获得性感染的风险。市场上的许多涂料产品都声称具有“抗菌”功能。然而，目前的产品具有显著的不足，包括弱的抗微生物活性、微生物耐药性的风险以及一旦施用涂料就难以监测和扩展抗微生物功能。为了解决这些问题，在这个拟议的项目中，我们将使用聚合物N-卤胺，一类广泛使用的水和食品消毒剂，作为抗菌添加剂，以提供对细菌（包括耐药物种），霉菌和其他真菌物种，病毒和孢子的杀菌效果。N-卤胺是含有一个或多个氮-卤素共价键的化合物。N-卤胺具有与次氯酸盐漂白剂类似的抗菌功效，但它们更稳定，无腐蚀性，没有报道的微生物耐药性病例，并且产生卤代烃的趋势要小得多。在本技术中，将本实验室开发的新的N-卤胺单体N-氯-2，2，6，6-四甲基-4-哌啶基丙烯酸酯（Cl-TMPA）聚合以制备聚合的N-卤胺乳液。在传统的水性乳胶漆中加入少量的这种乳液，新的涂料将能够对各种微生物提供有效的抗菌活性。预期抗微生物活性在正常使用下持续油漆的寿命。测试条件（例如，重土、洪水等）可能会消耗更多的氯，从而缩短抗菌持续时间。然而，新涂料的抗菌功能可以通过简单的碘化钾/淀粉测试轻松监测。也就是说，聚合的N-卤胺将与碘化钾反应，与淀粉一起产生深蓝色。因此，该测试确定涂料是否仍然提供抗微生物功能。如果显示抗微生物功能丧失，则可以通过用稀释的次氯酸盐漂白剂擦拭表面来恢复聚合的N-卤胺结构，以补充损失的氯并再生抗微生物功能。可以根据需要重复充电。如果成功，这项技术将提供一种创新的方法，在广泛的应用中保护高接触、高风险的表面，这将对健康产生广泛而重大的影响。这项短期铁路计划第一阶段研究的目的，是在继续和扩展该计划前，先确定新方法的可行性和成效。拟议研究的具体目标是：（1）创建聚合物N-卤胺乳胶乳液;（2）将聚合物N-卤胺乳胶乳液与商业上重要的乳胶漆混合，并表征所开发的新涂料的物理性质、抗菌性能和生物相容性;以及（3）初步确定新方法的成本。 公共卫生相关性：新涂料的独特功能包括对细菌，霉菌和其他真菌物种，病毒和孢子的广谱抗菌谱，易于监测抗菌活性，如果意外失去抗菌功能，N-卤胺的可再充电性，以及微生物耐药性的低风险。这些优点使得新型聚合物N-卤胺基抗微生物涂料成为保护住宅、商业、机构、工业和其他相关设施中的高接触、高风险表面的有吸引力的候选物。STTR第一阶段的研究将作为该项目继续和扩展的基础，并最终将产品商业化，以改善各种环境表面的微生物质量，这将对健康产生广泛而重大的影响。