Genetics

遗传学

• 批准号: 7827984
• 负责人: Nora C Heisterkamp
• 金额: $ 31.66万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7827984
• 关键词: Consultations; Equipment; Fostering; Generations; Genetic; Genotype; Hand; Ice; Maintenance; Microsurgery; Molecular Genetics; Morphogenesis; Mus; Resources; Screening procedure; Services; Time; Training; Transgenic Organisms; Work; cost; experience; injury and repair; lung basal segment; member; mutant; mutant mouse model; programs

The purpose of the Mouse Genetics Core is to provide routine as well as specialized support services pertaining to mice, to members of the Program Project including Projects 1, 2, 4, and 5. Almost all of the projects in this program Project make use of g enetically modified m ice. T he objective of the Core unit is to provide the following services and resources to members of the Program Project: 1. Specialized husbandry services, including cross-fostering, putting in timed matings and checking of plugs; 2. Hands-on work to rederive strains for importation purposes, training and consultation for colony management, the generation, maintenance and screening of genetically modified mice; 3. Genotyping of genetically modified mice; 4. Equipment for microsurgery and the generation of transgenic and null mutants The Projects all make use of mice which require genotyping for each new generation. The Core will provide efficient and cost-effective genotyping services. The Core Leader, Nora Heisterkamp, has over 15 years experience with the generation and husbandry of genetically modified mice including both transgenic as well as null mutant mouse models. She will be assisted by a Res. Asst. II who will perform most of the hands-on work.

小鼠遗传学核心的目的是提供常规和专业支持 与mice有关的服务，包括项目1，2，4和5的计划项目的成员。 这个项目中几乎所有的项目都使用了基因修饰的小鼠。他不 核心股的目标是为成员提供以下服务和资源， 1.专业的畜牧服务，包括交叉培育，定时投放 插头的匹配和检查; 2.为进口目的重新衍生菌株的实际工作， 提供有关菌落管理的培训和咨询， 转基因小鼠; 3.转基因小鼠的基因分型; 4.设备 显微手术和转基因和无效突变体的产生 这些项目都使用了需要对每一代进行基因分型的小鼠。核心 将提供高效和具有成本效益的基因分型服务。核心领袖诺拉·海斯特坎普 拥有超过15年的转基因小鼠生产和饲养经验 包括转基因以及无效突变小鼠模型。她将得到一个资源的帮助。 二当家谁将执行大部分的动手工作。