Habits and cues in alcohol drinking: Dynamic striatal activity

饮酒的习惯和线索：动态纹状体活动

• 批准号: 7810531
• 负责人: Donita L Robinson
• 金额: $ 22.2万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7810531
• 关键词: Address; Alcohol consumption; Alcohols; Animal Model; Anticonvulsants; Arts; Behavior; Behavioral; Benchmarking; Brain; Clinic; Consumption; Corpus striatum structure; Cues; Data; Development; Dopamine; Dorsal; Dose; Effectiveness; Employment; Event; Extinction (Psychology); Funding; Future; Glutamates; Goals; Grant; Habits; Lead; Link; Methodology; Modeling; Naltrexone; National Institute on Alcohol Abuse and Alcoholism; Neurons; Opioid Receptor; Parents; Pharmaceutical Preparations; Pharmacotherapy; Play; Rattus; Recovery; Reinforcement Schedule; Relapse; Research Personnel; Resistance; Rewards; Role; Scanning; Schedule; Self Administration; Self-Administered; Strategic Planning; Sucrose; Testing; Therapeutic; Therapeutic Effect; Time; Training; Treatment Efficacy; United States National Institutes of Health; Yin; alcohol effect; alcohol reinforcement; alcohol response; alcohol reward; alcohol seeking behavior; alcoholism therapy; behavioral pharmacology; comparative; comparative effectiveness; drinking; effectiveness research; extracellular; gamma-Aminobutyric Acid; improved; innovation; novel; parent grant; pre-clinical; preclinical study; prevent; public health relevance; research study; response; topiramate; transmission process

DESCRIPTION (provided by applicant): This is a Competitive Revision Application in response to NOT-OD-09-058 "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications." The parent R01 grant investigates neurodynamics (neuronal firing, dopamine release) in the dorsal striatum during goal-directed and habitual alcohol drinking and relapse-like behavior. The supplement will compare the behavioral pharmacology of therapeutic drugs on goal-directed versus habitual alcohol drinking and relapse-like behavior. The resulting data may have a profound impact on the interpretation of preclinical studies of therapeutic drugs for treatment of alcoholism, and could lead to improved preclinical animal models of alcohol drinking and relapse-like behavior. These non-overlapping aims are synergistic with the parent grant and will lead to future studies to determine the effect of therapeutic drugs on neurodynamics in the striatum during alcohol self-administration and relapse-like behavior. The supplemental aims comply with the justification of the Recovery Act by enabling hiring of new full-time and part-time staff. The supplemental aims also address the goal of the NIAAA Strategic Plan to improve animal models in medication development and the NIH goal of comparative effectiveness research (preclinical). PUBLIC HEALTH RELEVANCE: This competitive revision will expand the parent grant by comparatively evaluating the therapeutic efficacy of naltrexone and topiramate on goal-directed versus habit-driven alcohol drinking and relapse-like behavior. In compliance with the purpose of the Recovery Act, it will create new full-time and part-time employment.

描述（由申请人提供）：这是一份竞争性修订申请，响应no - od -09-058“NIH宣布为竞争性修订申请提供恢复法案资金”。父母R01基金研究目标导向、习惯性饮酒和复发样行为期间背纹状体的神经动力学（神经元放电、多巴胺释放）。该补充将比较治疗药物在目标导向与习惯性饮酒和复发样行为方面的行为药理学。由此产生的数据可能对酒精中毒治疗药物的临床前研究的解释产生深远的影响，并可能导致改进临床前饮酒和复发样行为的动物模型。这些不重叠的目标与父母的资助是协同的，并将导致未来的研究，以确定治疗药物对纹状体神经动力学在酒精自我给药和复发样行为期间的影响。补充目标符合《复苏法》的理由，允许雇用新的全职和兼职工作人员。补充目的还涉及NIAAA战略计划的目标，即改善药物开发中的动物模型和NIH的比较有效性研究目标（临床前）。