Habits and cues in alcohol drinking: Dynamic striatal activity

描述（由申请人提供）：这是一份竞争性修订申请，以回应NOT-OD-09-058“NIH宣布恢复法案资金可用于竞争性修订申请”。“父母R 01补助金调查在目标导向和习惯性饮酒和复发行为期间背侧纹状体的神经动力学（神经元放电，多巴胺释放）。增刊将比较目标导向与习惯性饮酒和复发样行为的治疗药物的行为药理学。由此产生的数据可能对解释治疗药物治疗酒精中毒的临床前研究产生深远的影响，并可能导致改善饮酒和复发样行为的临床前动物模型。这些不重叠的目标与父母资助是协同作用的，并将导致未来的研究，以确定治疗药物对酒精自我管理和复发样行为期间纹状体神经动力学的影响。补充目标符合《复苏法》的理由，允许雇用新的全职和兼职工作人员。补充目标还涉及NIAAA战略计划的目标，即改善药物开发中的动物模型和NIH比较有效性研究（临床前）的目标。 公共卫生相关性：这项竞争性修订将通过比较评估纳洛酮和托吡酯对目标导向与习惯驱动的饮酒和复发样行为的治疗效果来扩大父母资助。根据《复苏法》的目的，它将创造新的全职和兼职就业机会。

DESCRIPTION (provided by applicant): This is a Competitive Revision Application in response to NOT-OD-09-058 "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications." The parent R01 grant investigates neurodynamics (neuronal firing, dopamine release) in the dorsal striatum during goal-directed and habitual alcohol drinking and relapse-like behavior. The supplement will compare the behavioral pharmacology of therapeutic drugs on goal-directed versus habitual alcohol drinking and relapse-like behavior. The resulting data may have a profound impact on the interpretation of preclinical studies of therapeutic drugs for treatment of alcoholism, and could lead to improved preclinical animal models of alcohol drinking and relapse-like behavior. These non-overlapping aims are synergistic with the parent grant and will lead to future studies to determine the effect of therapeutic drugs on neurodynamics in the striatum during alcohol self-administration and relapse-like behavior. The supplemental aims comply with the justification of the Recovery Act by enabling hiring of new full-time and part-time staff. The supplemental aims also address the goal of the NIAAA Strategic Plan to improve animal models in medication development and the NIH goal of comparative effectiveness research (preclinical). PUBLIC HEALTH RELEVANCE: This competitive revision will expand the parent grant by comparatively evaluating the therapeutic efficacy of naltrexone and topiramate on goal-directed versus habit-driven alcohol drinking and relapse-like behavior. In compliance with the purpose of the Recovery Act, it will create new full-time and part-time employment.