Regulation of CR2/CD21 Expression and Activation

CR2/CD21 表达和激活的调节

基本信息

  • 批准号:
    7880369
  • 负责人:
  • 金额:
    $ 1.3万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-08-11 至 2010-09-30
  • 项目状态:
    已结题

项目摘要

The murine CD21/Cr2 gene encodes two proteins implicated in the acquisition of an optimal immune response. The CD21 pathway includes signals for B cell survival and optimal activation, and presentation of native antigen by follicular dendritic cells (FDC) in the germinal centers of the spleen. The expression of murine CD21 is tightly controlled. The proteins are found on B cells during specific stages of differentiation and are expressed by FDC once they have taken up their position within the spleen. This competing application proposes to continue our analysis of the mechanism of CD21 gene control and the functions of the CD21 proteins in the generation of an appropriate immune response. We have demonstrated that promoter and intronic elements regulate the CD21 gene. We propose to continue our analysis of the transcriptional control of CD21, incorporating the comparative analysis of two other genes, CD19 and CD23, that are expressed at similar times of B cell differentiation. We will also continue our examination of a mutant mouse line with an engineered deletion of the CD21 intronic control region. These analyses also include the role of transcriptional activators from herpes virus that induce CD21 and CD23 expression, and the effect of such over expression on the immune response. Our analysis of the function of the CD21 proteins will focus upon the role of the CD21 proteins as complement receptors enhancing both the acquired and innate immune responses including the generation of the immunoglobulin isotypes. We will also analyze the role of various gene products whose expression is critically altered in CD21 deficient animals during immune activation. The generation of an appropriate immune response is critical to the health of the individual. The CD21 proteins straddle the fields of acquired and innate immune responses such that their manipulation could influence immediate responses to an infection as well as the more long term consequences of immunologic memory.
小鼠CD21/Cr2基因编码两种与获得最佳免疫有关的蛋白质

项目成果

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会议论文数量(0)
专利数量(0)

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John Weis其他文献

John Weis的其他文献

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{{ truncateString('John Weis', 18)}}的其他基金

Role of Ifitm/Fragilis proteins as intracellular shuttles during cell activation
Ifitm/Fragilis 蛋白在细胞激活过程中作为细胞内穿梭机的作用
  • 批准号:
    8043909
  • 财政年份:
    2010
  • 资助金额:
    $ 1.3万
  • 项目类别:
Role of Ifitm/Fragilis proteins as intracellular shuttles during cell activation
Ifitm/Fragilis 蛋白在细胞激活过程中作为细胞内穿梭机的作用
  • 批准号:
    8197848
  • 财政年份:
    2010
  • 资助金额:
    $ 1.3万
  • 项目类别:
Role of the Fragilis Proteins in the Immune Response
脆弱蛋白在免疫反应中的作用
  • 批准号:
    6894009
  • 财政年份:
    2004
  • 资助金额:
    $ 1.3万
  • 项目类别:
Role of the Fragilis Proteins in the Immune Response
脆弱蛋白在免疫反应中的作用
  • 批准号:
    6804271
  • 财政年份:
    2004
  • 资助金额:
    $ 1.3万
  • 项目类别:
Role of Pactolus in the innate immune response
Pactolus 在先天免疫反应中的作用
  • 批准号:
    6631980
  • 财政年份:
    1998
  • 资助金额:
    $ 1.3万
  • 项目类别:
PACTOLUS AND MAST CELL AND MORROW CELL FUNCTION
PACTOLUS、肥大细胞和莫罗细胞功能
  • 批准号:
    2705528
  • 财政年份:
    1998
  • 资助金额:
    $ 1.3万
  • 项目类别:
Role of Pactolus in the innate immune response
Pactolus 在先天免疫反应中的作用
  • 批准号:
    6886799
  • 财政年份:
    1998
  • 资助金额:
    $ 1.3万
  • 项目类别:
Role of Pactolus in the innate immune response
Pactolus 在先天免疫反应中的作用
  • 批准号:
    6721189
  • 财政年份:
    1998
  • 资助金额:
    $ 1.3万
  • 项目类别:
PACTOLUS AND MAST CELL AND MORROW CELL FUNCTION
PACTOLUS、肥大细胞和莫罗细胞功能
  • 批准号:
    2887616
  • 财政年份:
    1998
  • 资助金额:
    $ 1.3万
  • 项目类别:
Role of Pactolus in the innate immune response
Pactolus 在先天免疫反应中的作用
  • 批准号:
    6510757
  • 财政年份:
    1998
  • 资助金额:
    $ 1.3万
  • 项目类别:

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