Regulation of CR2/CD21 Expression and Activation
CR2/CD21 表达和激活的调节
基本信息
- 批准号:7880369
- 负责人:
- 金额:$ 1.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-11 至 2010-09-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAntigensB cell differentiationB-Lymphocyte SubsetsB-LymphocytesBindingBiological AssayBiological ModelsCD19 geneCell SurvivalCellsComplement 3d ReceptorsComplement ReceptorDefectElementsEngineeringEnvironmentFollicular Dendritic CellsGenerationsGenesGoalsHealthHerpesviridaeImmuneImmune responseImmunoglobulin IsotypesImmunologic MemoryIndividualInfectionInflammation MediatorsLigand BindingMediator of activation proteinMolecularMusMutant Strains MiceMutationPathway interactionsPopulationPositioning AttributeProteinsReceptor SignalingRegulationRegulator GenesRegulatory ElementRoleSignal PathwaySignal TransductionSiteSpleenStagingStructure of germinal center of lymph nodeTimeTranscription CoactivatorTranscriptional RegulationVirus Diseasescomparativedepresseddesignnovelpromoterreceptorresearch studyresponsetranscription factor
项目摘要
The murine CD21/Cr2 gene encodes two proteins implicated in the acquisition of an optimal immune
response. The CD21 pathway includes signals for B cell survival and optimal activation, and presentation of
native antigen by follicular dendritic cells (FDC) in the germinal centers of the spleen. The expression of
murine CD21 is tightly controlled. The proteins are found on B cells during specific stages of differentiation
and are expressed by FDC once they have taken up their position within the spleen.
This competing application proposes to continue our analysis of the mechanism of CD21 gene control
and the functions of the CD21 proteins in the generation of an appropriate immune response. We have
demonstrated that promoter and intronic elements regulate the CD21 gene. We propose to continue our
analysis of the transcriptional control of CD21, incorporating the comparative analysis of two other genes,
CD19 and CD23, that are expressed at similar times of B cell differentiation. We will also continue our
examination of a mutant mouse line with an engineered deletion of the CD21 intronic control region. These
analyses also include the role of transcriptional activators from herpes virus that induce CD21 and CD23
expression, and the effect of such over expression on the immune response.
Our analysis of the function of the CD21 proteins will focus upon the role of the CD21 proteins as
complement receptors enhancing both the acquired and innate immune responses including the generation
of the immunoglobulin isotypes. We will also analyze the role of various gene products whose expression is
critically altered in CD21 deficient animals during immune activation.
The generation of an appropriate immune response is critical to the health of the individual. The CD21
proteins straddle the fields of acquired and innate immune responses such that their manipulation could
influence immediate responses to an infection as well as the more long term consequences of immunologic
memory.
小鼠CD21/Cr2基因编码两种与获得最佳免疫有关的蛋白质
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Weis其他文献
John Weis的其他文献
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{{ truncateString('John Weis', 18)}}的其他基金
Role of Ifitm/Fragilis proteins as intracellular shuttles during cell activation
Ifitm/Fragilis 蛋白在细胞激活过程中作为细胞内穿梭机的作用
- 批准号:
8043909 - 财政年份:2010
- 资助金额:
$ 1.3万 - 项目类别:
Role of Ifitm/Fragilis proteins as intracellular shuttles during cell activation
Ifitm/Fragilis 蛋白在细胞激活过程中作为细胞内穿梭机的作用
- 批准号:
8197848 - 财政年份:2010
- 资助金额:
$ 1.3万 - 项目类别:
Role of the Fragilis Proteins in the Immune Response
脆弱蛋白在免疫反应中的作用
- 批准号:
6894009 - 财政年份:2004
- 资助金额:
$ 1.3万 - 项目类别:
Role of the Fragilis Proteins in the Immune Response
脆弱蛋白在免疫反应中的作用
- 批准号:
6804271 - 财政年份:2004
- 资助金额:
$ 1.3万 - 项目类别:
Role of Pactolus in the innate immune response
Pactolus 在先天免疫反应中的作用
- 批准号:
6631980 - 财政年份:1998
- 资助金额:
$ 1.3万 - 项目类别:
PACTOLUS AND MAST CELL AND MORROW CELL FUNCTION
PACTOLUS、肥大细胞和莫罗细胞功能
- 批准号:
2705528 - 财政年份:1998
- 资助金额:
$ 1.3万 - 项目类别:
Role of Pactolus in the innate immune response
Pactolus 在先天免疫反应中的作用
- 批准号:
6886799 - 财政年份:1998
- 资助金额:
$ 1.3万 - 项目类别:
Role of Pactolus in the innate immune response
Pactolus 在先天免疫反应中的作用
- 批准号:
6721189 - 财政年份:1998
- 资助金额:
$ 1.3万 - 项目类别:
PACTOLUS AND MAST CELL AND MORROW CELL FUNCTION
PACTOLUS、肥大细胞和莫罗细胞功能
- 批准号:
2887616 - 财政年份:1998
- 资助金额:
$ 1.3万 - 项目类别:
Role of Pactolus in the innate immune response
Pactolus 在先天免疫反应中的作用
- 批准号:
6510757 - 财政年份:1998
- 资助金额:
$ 1.3万 - 项目类别:
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