课题基金 / 基金详情

STRUCTURE/FUNCTION HUMAN B CELL DIFFERENTIATION ANTIGENS

STRUCTURE/FUNCTION HUMAN B CELL DIFFERENTIATION ANTIGENS
结构/功能人 B 细胞分化抗原
批准号:
3293713
负责人:
Edward A Clark
金额:
$9.7万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-12-01 至 1989-11-30

项目摘要

项目成果

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中文摘要
翻译
本研究计划的主要目标是研究如何
英文摘要
The principal goal of this research proposal is to investigate how proliferation and differentiation of human B cells are regulated. A major focus will be on interactions occurring at the cell surface that involve B cell differentiation antigens. Our approach stems from our findings that monoclonal antibodies (mAb) to certain epitopes on certain B cell-associated antigens have agonistic activity: the mAb 1F5 to the 35Kd pan B cell marker Bp35 activates resting B cells to leave G0 and enter the G1 phase of the cell cycle. In contrast, the mAb G28-5 to the 50Kd pan B cell antigen Bp50 does not affect resting B cells, but like certain B cell growth factors (BCGF), stimulates activated B cells to traverse the cell cycle. Our rationale is that agonistic mAb provide an alternative and complementary approach to soluble factors for studying B cell immunoregulation. Our current hypothesis is that Bp35 and Bp50 are surface receptors for either soluble B cell stimulating factors (BSF) or for transmembrane cell-cell interaction signals from accessory cells. The specific aims of the proposal are: 1) to test whether Bp35 or Bp50 are receptors for known soluble BSF, 2) to assess the effects that anti-Bp35 and anti-Bp50 agonistic mAb have on growth factor regulation, 3) to characterize and contrast the intracellular pathways that are induced in B cells by agonistic mAb, and 4) to clone and isolate the gene which encodes for the Bp35 surface polypeptide. Further information about Bp35 and Bp50 structure and their role in B cell activation will contribute to our understanding of the etiology and possible control of lymphoid malignancies and antibody-mediated autoimmune diseases.
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Development of Novel CD180-Based Cancer Immunotherapeutics
  • 批准号:
    10381384
  • 项目类别:
  • 资助金额:
    $39.8万
  • 财政年份:
    2022
  • 负责人:
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  • 依托单位:
Mouse Resource Core
  • 批准号:
    8811087
  • 项目类别:
  • 资助金额:
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  • 财政年份:
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  • 依托单位:
Establishing and characterizing BAFF RFP reporter and BAFF knockin mice
  • 批准号:
    8468991
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2012
  • 负责人:
    Edward A Clark
  • 依托单位:
Establishing and characterizing BAFF RFP reporter and BAFF knockin mice
  • 批准号:
    8353277
  • 项目类别:
  • 资助金额:
    $8.9万
  • 财政年份:
    2012
  • 负责人:
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  • 依托单位:
海外基金