Demographic Analysis of Healthy Longevity in China

描述(由申请人提供)：我们请求8个月的支持，直至2009年7月31日R01完成，并获得来自中国资源的大量匹配资金，用于额外的DNA数据收集和在定于2008年下半年进行的最后一次由中国资助的纵向健康长寿调查中，增加一组40岁-的受访者。我们计划使用Oragene工具箱从22个省约937个县/市(不包括6个长寿地区)的15,409名受访者中收集唾液DNA。我们将通过医务人员的居家健康检查，从六个百岁老人密度特别高的六个长寿地区的6400名受访者的自愿参与者中收集血液(或唾液)样本和生物标志物。总体而言，我们将在全国范围内从21,809名受访者的自愿参与者那里收集DNA样本，其中包括约3,404名百岁老人、4,504名非老年人、4,504名八旬老人、4,393名65-79岁的年轻老年人和3,404名40岁-的中年对照组。年龄最大的受访者(即80岁以上的受访者)将包括约1800对兄弟姐妹。此外，我们还将在样本中纳入六大长寿地区800名百岁老人的800名子女和800名孙辈。我们估计，大约有19492名受访者(占总样本的90%)将自愿捐献唾液或血液DNA样本。我们将把1998年、2000年、2002年、2005年和2008年收集的多波CLHLS数据存档，并使其便于用户使用，供所有感兴趣的学者广泛使用。在2009年8月1日之后的预期研究支持下，包括将父母的R01资助续期5年，以及中国的资金用于支付中国的大部分费用，我们将为每个愿意贡献DNA的参与者确定数百个或更多候选基因座的基因型。我们将开发和应用人口统计学/统计学方法来分析这项研究产生的非遗传和遗传数据，以评估社会、行为和环境风险因素和候选基因的影响，以及它们对高龄健康和长寿的影响。我们强调，这个环境-基因相互作用项目的最终目标是提出可能的合理政策和计划，整合社会、行为、环境和遗传学(例如药物和转基因治疗)干预措施，以有效地提高老年人的健康水平。公共卫生相关性：该补充项目主要用于2008年下半年中国健康长寿纵向调查浪潮中的额外DNA数据收集，中方资源提供了大量配套资金。我们的目标是更好地了解社会、行为、环境和遗传因素以及它们之间的相互作用对健康长寿的影响。这个环境-基因相互作用项目的最终目标是提出可能的合理政策和计划，将行为、环境和遗传学(如药物和转基因治疗)干预措施整合在一起，有效地提高老年人的健康水平。

DESCRIPTION (provided by applicant): We are requesting an 8-month support through 7/31/09 when the R01 completes, with substantial matching funds from Chinese resources, for additional DNA data collection and the addition of a control group of interviewees aged 40-64 in the last funded Chinese Longitudinal Healthy Longevity Survey (CLHLS) wave scheduled for the second half of 2008. We plan to collect saliva DNA using Oragene tool kits from voluntary participants among 15,409 interviewees in the sample of about 937 counties/cities (other than the six longevity areas) in 22 provinces. We will collect blood (or saliva) samples and biomarkers through in- home health examinations by medical personnel from voluntary participants among 6,400 interviewees in the six longevity areas where the density of centenarians is exceptionally high. In total, we will collect DNA samples nationwide from willing participants among 21,809 interviewees, including about 3,404 centenarians, 4,504 nonagenarians, 4,504 octogenarians, 4,393 younger elderly aged 65-79, and 3,404 middle-aged controls aged 40-64. The oldest-old interviewees (i.e., those aged 80+) will include about 1,800 sibling pairs. In addition, we will also include in the sample 800 children and 800 grandchildren of the 800 centenarians in the six longevity areas. We estimate that about 19,492 interviewees (90 percent of the total sample) will voluntarily contribute either saliva or blood DNA samples. We will archive the multi-wave CLHLS data collected in 1998, 2000, 2002, 2005, and 2008, and make them user-friendly and widely available to all interested scholars. With anticipated research support after 8/1/2009, including a renewal of the parent R01 grant for five additional years of funding and Chinese funds to cover most of the costs in China, we will determine the genotype at a couple of hundred or more candidate loci for each of the willing participants who contribute DNA. We will develop and apply demographic/statistical methods for analyzing the non-genetic and genetic data resulted from this study to estimate the impacts of social, behavioral and environmental risk-factors and candidate genes, as well as their interactions on health and longevity at advanced ages. We emphasize that the ultimate goal of this environment-genes interaction project is to propose possible sound policies and programs that integrate social, behavioral, environmental and genetics (e.g. drugs and transgenic treatments) interventions for effectively enhancing human health at advanced ages. PUBLIC HEALTH RELEVANCE: This supplement project is mainly for additional DNA data collection in the Chinese Longitudinal Healthy Longevity Survey wave scheduled for the second half of 2008, with substantial matching funds from Chinese resources. We aim to gain a better understanding of the impacts of social, behavior, environmental and genetic factors and their interactions on healthy longevity. The ultimate goal of this environment-genes interaction project is to propose possible sound policies and programs that integrate behavior, environmental, and genetics (e.g. drugs and transgenic treatments) interventions for effectively enhancing human health at advanced ages.