Demographic Analysis on Determinants of Healthy Longevity in China

描述（由申请人提供）：这是为继续研究项目“中国健康寿命决定因素的人口统计学分析”（PI: Yi Zeng）而重新提交的竞争性更新R01申请。我们正在申请从2010年7月1日到2015年6月30日为期5年的研究支持，中国资源将提供大量配套资金。这项持续R01的目标是更好地了解社会、行为和遗传因素及其相互作用对健康寿命的影响。更具体地说，我们计划通过以下研究活动来实现我们的目标。(1)收集2008年首次提供DNA样本的1.4万名受访者2011年和2014年的死亡率和健康状况变化的随访数据。(2)采用群体关联分析和收敛统计分析两阶段研究设计，通过全基因组筛选和基因分型鉴定健康长寿相关基因。(3)创新运用先进的人口学/统计学方法，综合分析本项目产生的CLHLS多波纵向调查数据和基因型数据，评估环境和遗传风险因素对老年人健康和寿命的影响。除了研究环境和遗传因素之间的一般关联外，我们计划特别关注分析环境-基因相互作用对健康长寿的影响。(4)建立基因型和表型数据库（包括健康状况、残疾状况、行为、生活方式、饮食、心理特征、生存和死亡等）。我们将使这个世界上最大的百岁老人、九十岁老人、年轻老年人和中年对照样本的数据库用户友好，并广泛提供给所有感兴趣的学者，同时消除所有可能用于识别个体参与者的信息。

DESCRIPTION (provided by applicant): This is a resubmission of a competitive renewal R01 application to continue the research project "Demographic Analysis on Determinants of Healthy Longevity in China" (PI: Yi Zeng). We are requesting 5-year research support from 7/1/2010 to 6/30/2015, with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral, and genetic factors and their interactions on healthy longevity. More specifically, we plan to achieve our goal through the following research activities. (1) Collect follow-up data on mortality and changes in health status in 2011 and 2014 for those 14,000 interviewees who contributed DNA samples for the first time in 2008. (2) Identify the healthy longevity related genes by genome-wide screening and genotyping with the two-stage study design of population association analysis as well as the convergent statistical analyses. (3) Innovatively apply advanced demographic/statistical methods to analyze the CLHLS multi-wave longitudinal survey data and genotype data produced by this project in an integrated way to estimate the impacts of environmental and genetic risk factors on health and longevity at old ages. In addition to studying the general associations between environmental and genetic factors, we plan to pay particular attention to analyze the effects of environment-gene interactions on healthy longevity. (4) Develop the genotypic and phenotypic database (including health conditions, disability status, behavior, life style, diet, psychological characteristics, survival and death, etc.). We will make this database of the world's largest sample of centenarians, nonagenarians, younger elderly, and middle-aged controls user-friendly and widely available to all interested scholars, while eliminating all information which may be potentially used to identify the individual participants. PUBLIC HEALTH RELEVANCE: This is the resubmission of the competitive renewal R01 application to continue the research project "Demographic Analysis on Determinants of Healthy Longevity in China" (PI: Yi Zeng), with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral and genetic factors and their interactions on healthy longevity. We emphasize studying factors affecting health at old ages in the context of expanding lifespan, based on well-conducted interdisciplinary research.