中国健康长寿影响因素的人口统计分析-猫眼课题宝

中国健康长寿影响因素的人口统计分析

批准号：

8715660

负责人：

YI ZENG

金额：

$20.69万

依托单位：

DUKE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2004

资助国家：

美国

项目状态：

已结题

起止时间：

2004-09-01 至 2016-05-31

来源：

https://reporter.nih.gov/project-details/8715660

关键词：

Address Affect Age Archives Area Attention Back Behavior Behavioral Behavioral Genetics Candidate Disease Gene Cause of Death Centenarian Cessation of life Characteristics China Chinese People Cities Climate Code Collection Communities Confidentiality Country County Cross-Sectional Studies DNA Data Data Analyses Databases Demographic Analyses Development Diet Dimensions Elderly Environment Environmental Pollution Environmental Risk Factor Event Family Family member Female Fertility First Degree Relative Funding Genes Genetic Genotype Goals Grant Happiness Health Health Status Health behavior Heterogeneity Human Individual Interdisciplinary Study Interview Investigation Joints Knowledge Learning Life Life Stress Life Style Longevity Longitudinal Surveys Measures Methods Michigan Molecular Morbidity - disease rate Names Nonagenarian Octogenarian Outcome Parents Participant Phenotype Population Publications Publishing Religion and Spirituality Reporting Research Research Activity Research Design Research Personnel Research Project Grants Research Support Resources Respondent Sample Size Sampling Siblings Social Behavior Social Impacts Staging Statistical Methods Surveys Telephone Testing Time Typology United States National Institutes of Health Universities Woman aged base biological systems child bearing cohort comparative coping cost data sharing database of Genotypes and Phenotypes disability follow-up gene environment interaction genetic analysis genetic risk factor genome wide association study healthy aging indexing innovation interest middle age mortality novel physical conditioning positive emotional state programs psychologic public health relevance resilience social socioeconomics user-friendly

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DESCRIPTION (provided by applicant): This is a resubmission of a competitive renewal R01 application to continue the research project "Demographic Analysis on Determinants of Healthy Longevity in China" (PI: Yi Zeng). We are requesting 5-year research support from 7/1/2010 to 6/30/2015, with substantial matching funds from Chinese resources. The goal of this proposed continuing R01 is to search for a better understanding of the effects of social, behavioral, and genetic factors and their interactions on healthy longevity. More specifically, we plan to achieve our goal through the following research activities. (1) Collect follow-up data on mortality and changes in health status in 2011 and 2014 for those 14,000 interviewees who contributed DNA samples for the first time in 2008. (2) Identify the healthy longevity related genes by genome-wide screening and genotyping with the two-stage study design of population association analysis as well as the convergent statistical analyses. (3) Innovatively apply advanced demographic/statistical methods to analyze the CLHLS multi-wave longitudinal survey data and genotype data produced by this project in an integrated way to estimate the impacts of environmental and genetic risk factors on health and longevity at old ages. In addition to studying the general associations between environmental and genetic factors, we plan to pay particular attention to analyze the effects of environment-gene interactions on healthy longevity. (4) Develop the genotypic and phenotypic database (including health conditions, disability status, behavior, life style, diet, psychological characteristics, survival and death, etc.). We will make this database of the world's largest sample of centenarians, nonagenarians, younger elderly, and middle-aged controls user-friendly and widely available to all interested scholars, while eliminating all information which may be potentially used to identify the individual participants.

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