Perturbation of Ras-Erk and phosphatidylinositol 3-kinase signalling pathways by the hepatitis C virus NS5A protein

丙型肝炎病毒 NS5A 蛋白对 Ras-Erk 和磷脂酰肌醇 3 激酶信号通路的干扰

• 批准号: G0401577/1
• 负责人: MPG Harris
• 金额: $ 52.77万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0401577%2F1
• 关键词: Perturbation; Ras; Erk; phosphatidylinositol; kinase

The World Health Organisation estimates that 170 million individuals are infected with the hepatitis C virus,with 3-4 million new cases occurring each year. Hepatitis is a disease of the liver, a very important organ in the body. The virus manages to survive in liver cells for many years before leading to disease which can result both in liver failure and liver cancer. Although there are treatments for the infection, they do not always work and often have unpleasant side effects ? new and better drugs are urgently needed. This research aims to discover how one of the components of the virus, a protein called NS5A, works to alter the function of liver cells that are infected with the virus, both to ensure virus survival and contribute to the disease caused by the virus. This is important becauseif we can understand how this protein works then we may be able to devise new chemicals that prevent its function ? these could have potential as new drugs to treat patients who have hepatitis C virus infection.

世界卫生组织估计，有1.7亿人感染丙型肝炎病毒，每年有300万至400万新病例。肝炎是肝脏的一种疾病，肝脏是身体中非常重要的器官。这种病毒在肝细胞中存活多年，然后导致疾病，可能导致肝功能衰竭和肝癌。虽然有治疗感染，他们并不总是工作，往往有不愉快的副作用？迫切需要新的和更好的药物。这项研究旨在发现病毒的一种成分，一种名为NS5A的蛋白质，如何改变感染病毒的肝细胞的功能，既确保病毒存活，又有助于病毒引起的疾病。这一点很重要，因为如果我们能理解这种蛋白质是如何工作的，那么我们就有可能设计出新的化学物质来阻止它的功能。这些可能有潜力成为治疗丙型肝炎病毒感染患者的新药。