Identification of in vivo substrates of muscle atrophy-related ubiquitin ligases MAFbx and MuRF1

肌肉萎缩相关泛素连接酶 MAFbx 和 MuRF1 体内底物的鉴定

• 批准号: G0401644/1
• 负责人: Robert Layfield
• 金额: $ 23.59万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0401644%2F1
• 关键词: Identification; vivo; substrates; muscle; atrophy

Muscle wasting (also known as atrophy) occurs in many different diseases, for example in diabetes and cancer, and also when patients are immobilised following accidents or surgery. The loss of muscle that occurs in these cases is one of the major factors affecting recovery time, or indeed whether or not the patients do fully recover. In addition, as we get older, muscle wasting also occurs, which is one factor that can lead to loss of mobility. In order to develop drugs and therapies to help control muscle wasting, and to increase the quality of life for people affected by muscle wasting, we need a much better understanding of the changes which occur in muscle cells. In particular, we need to know what happens to the proteins which make up the muscle, and allow it to function properly. This application aims to work out the most important changes which occur in human muscle proteins during muscle wasting, which should allow us to develop better treatments for these conditions in the future.

肌肉萎缩（也称为萎缩）发生在许多不同的疾病中，例如糖尿病和癌症，以及当患者在事故或手术后固定时。在这些情况下发生的肌肉损失是影响恢复时间的主要因素之一，或者确实影响患者是否完全康复。此外，随着年龄的增长，肌肉萎缩也会发生，这是导致行动能力丧失的一个因素。为了开发药物和治疗方法来帮助控制肌肉萎缩，并提高受肌肉萎缩影响的人的生活质量，我们需要更好地了解肌肉细胞中发生的变化。特别是，我们需要知道组成肌肉的蛋白质发生了什么变化，并使其正常工作。该应用旨在研究肌肉萎缩期间人类肌肉蛋白质发生的最重要变化，这将使我们能够在未来开发出更好的治疗方法。