Continuation of the Edinburgh HIV Brain & Tissue Resource

爱丁堡艾滋病大脑的延续

• 批准号: G0500863/1
• 负责人: Colin Smith
• 金额: $ 40.19万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0500863%2F1
• 关键词: Continuation; Edinburgh; HIV; Brain; Tissue

The Edinburgh HIV Brain Bank represents a truly unique resource for research on the effects of HIV in the brain. It comprises brain and non-brain tissue samples from untreated, partially treated (Zidovudine, AZT and Didanosine, DDI) and well treated (triple therapy, HAART) HIV infected individuals, as well as from pre-AIDS individuals and age matched controls. Mortality from HIV/AIDS has fallen dramatically since the advent of HAART and most HIV-related deaths are now due to hepatitis or to drug overdose. HIV-associated dementia, HIV encephalitis and opportunistic infections are now rare but more subtle cognitive impairment remains a significant problem. We and others have recently described unexpected neuropathology findings in post-HAART cases, including levels of neuroinflammation and neurodegeneration which in some cases exceed those seen in HIV encephalitis cases. This raises concerns for the future brain health in similar individuals. Technological developments such as tissue microarray, single cell laser capture and proteomics permit novel experimental investigation of archival brain tissue samples. These two factors have lead to an increase in requests to the Edinburgh brain bank. Maintenace of this unique collection of HIV tissue samples continues to be essential for ongoing research in this field.

爱丁堡艾滋病毒脑库是研究艾滋病毒对大脑影响的真正独特的资源。它包括来自未治疗、部分治疗（齐多夫定、AZT和去羟肌苷，DDI）和良好治疗（三联疗法，HAART）的HIV感染个体以及来自AIDS前个体和年龄匹配对照的脑和非脑组织样品。自高效抗逆转录病毒疗法出现以来，艾滋病毒/艾滋病的死亡率大幅下降，目前大多数与艾滋病毒有关的死亡是由于肝炎或药物过量。与艾滋病毒相关的痴呆症、艾滋病毒脑炎和机会性感染现在很少见，但更微妙的认知障碍仍然是一个重大问题。我们和其他人最近描述了HAART后病例中意外的神经病理学发现，包括神经炎症和神经变性的水平，在某些情况下超过了HIV脑炎病例中观察到的水平。这引起了人们对类似个体未来大脑健康的担忧。技术的发展，如组织微阵列，单细胞激光捕获和蛋白质组学允许新的实验研究档案脑组织样本。这两个因素导致了对爱丁堡脑库的需求增加。保持这一独特的艾滋病毒组织样本收集对于这一领域正在进行的研究仍然至关重要。