Continuation of the Edinburgh HIV Brain & Tissue Resource

爱丁堡艾滋病毒脑库是研究艾滋病毒对大脑影响的真正独特资源。它包括来自未经治疗、部分治疗（齐多夫定、AZT和Didanosine， DDI）和治疗良好（三联疗法、HAART）的艾滋病毒感染者以及艾滋病前患者和年龄匹配的对照组的脑组织和非脑组织样本。自从HAART问世以来，艾滋病毒/艾滋病的死亡率急剧下降，现在大多数与艾滋病毒有关的死亡是由于肝炎或药物过量造成的。艾滋病毒相关的痴呆，艾滋病毒脑炎和机会性感染现在很少见，但更微妙的认知障碍仍然是一个重大问题。我们和其他人最近描述了在haart后病例中意想不到的神经病理学发现，包括神经炎症和神经变性的水平，在某些情况下超过了HIV脑炎病例的水平。这引起了人们对相似个体未来大脑健康的关注。技术的发展，如组织微阵列，单细胞激光捕获和蛋白质组学允许对档案脑组织样本进行新的实验研究。这两个因素导致对爱丁堡脑库的请求增加。维持这种独特的HIV组织样本收集对于该领域正在进行的研究仍然至关重要。

The Edinburgh HIV Brain Bank represents a truly unique resource for research on the effects of HIV in the brain. It comprises brain and non-brain tissue samples from untreated, partially treated (Zidovudine, AZT and Didanosine, DDI) and well treated (triple therapy, HAART) HIV infected individuals, as well as from pre-AIDS individuals and age matched controls. Mortality from HIV/AIDS has fallen dramatically since the advent of HAART and most HIV-related deaths are now due to hepatitis or to drug overdose. HIV-associated dementia, HIV encephalitis and opportunistic infections are now rare but more subtle cognitive impairment remains a significant problem. We and others have recently described unexpected neuropathology findings in post-HAART cases, including levels of neuroinflammation and neurodegeneration which in some cases exceed those seen in HIV encephalitis cases. This raises concerns for the future brain health in similar individuals. Technological developments such as tissue microarray, single cell laser capture and proteomics permit novel experimental investigation of archival brain tissue samples. These two factors have lead to an increase in requests to the Edinburgh brain bank. Maintenace of this unique collection of HIV tissue samples continues to be essential for ongoing research in this field.