Sudden Death Brain and Tissue Bank

猝死脑和组织库

• 批准号: G0600969/1
• 负责人: Colin Smith
• 金额: $ 78.93万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600969%2F1
• 关键词: Sudden; Death; Brain; Tissue; Bank

Brain banking has a long tradition of supporting research by providing human tissue samples for investigation of human brain disorders. Recent organ retention crises and the resulting public disquiet have accelerated the generally declining autopsy rate of consented post mortem examinations. This poses a threat to post mortem tissue collections and consequently for future research. Acquisition of control cases in different age groups and with no significant CNS pathology has been particularly difficult. This application proposes to respond to the present situation by seeking families’ authorisation for research use of brains examined in the setting of the forensic post mortem service. The purpose of this proposal is to collect not only control cases but also CNS disorders mainly encountered in the forensic setting by virtue of sudden death, eg head injury, drug overdose, suicide. This will fulfill a need for the general research community by providing control cases for whom review of the clinical history and examination of the brain exclude the presence of any CNS disorder. This application sets out a two year feasibility project to study the logistics and acceptability of establishing this service in Edinburgh. The applicants trust that this proposal would help to redress the difficulties encountered in recent years by many brain banks.

脑库有着悠久的传统，通过提供人体组织样本来支持研究，以调查人类大脑疾病。最近的器官保留危机和由此引起的公众不安加速了同意验尸的尸检率普遍下降。这对死后组织的收集和未来的研究构成了威胁。在不同年龄组中获得无显著CNS病理的对照病例特别困难。这项申请建议对目前的情况作出反应，寻求家属的授权，以便在法医验尸服务的背景下对大脑进行研究。本提案的目的是不仅收集对照病例，还收集法医环境中因猝死（如头部损伤、药物过量、自杀）而主要遇到的CNS疾病。这将通过提供对照病例来满足一般研究团体的需要，对这些病例进行临床病史审查和脑部检查排除了任何CNS疾病的存在。本申请列出了一个为期两年的可行性项目，以研究在爱丁堡建立这项服务的物流和可接受性。申请人相信，这项建议将有助于解决许多人才库近年来遇到的困难。