Sudden Death Brain and Tissue Bank

脑库通过为人类大脑疾病的研究提供人体组织样本来支持研究的传统由来已久。最近的器官保留危机和由此引起的公众不安加速了同意验尸的尸检率普遍下降的趋势。这对死后组织收集和未来的研究构成了威胁。在不同年龄组和没有明显中枢神经系统病理的对照病例的获取方面尤其困难。这项申请建议通过寻求家庭对在法医尸检服务中检查的大脑的研究使用授权来应对目前的情况。这项建议的目的不仅是收集对照病例，而且收集主要在法医背景下因猝死而遇到的中枢神经系统疾病，如头部损伤、药物过量、自杀。这将通过提供对照病例来满足一般研究社区的需求，这些病例回顾临床病史和大脑检查，排除了任何中枢神经系统疾病的存在。这份申请列出了一个为期两年的可行性项目，以研究在爱丁堡建立这项服务的后勤和可接受性。申请者相信，这项建议将有助于解决近年来许多脑库遇到的困难。

Brain banking has a long tradition of supporting research by providing human tissue samples for investigation of human brain disorders. Recent organ retention crises and the resulting public disquiet have accelerated the generally declining autopsy rate of consented post mortem examinations. This poses a threat to post mortem tissue collections and consequently for future research. Acquisition of control cases in different age groups and with no significant CNS pathology has been particularly difficult. This application proposes to respond to the present situation by seeking families’ authorisation for research use of brains examined in the setting of the forensic post mortem service. The purpose of this proposal is to collect not only control cases but also CNS disorders mainly encountered in the forensic setting by virtue of sudden death, eg head injury, drug overdose, suicide. This will fulfill a need for the general research community by providing control cases for whom review of the clinical history and examination of the brain exclude the presence of any CNS disorder. This application sets out a two year feasibility project to study the logistics and acceptability of establishing this service in Edinburgh. The applicants trust that this proposal would help to redress the difficulties encountered in recent years by many brain banks.