The Denver Network of the NHLBI Progenitor Cell Biology Consortium

NHLBI 祖细胞生物学联盟丹佛网络

• 批准号: 7678306
• 负责人: Dennis Roop
• 金额: $ 3.87万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7678306
• 关键词: Area; Arts; Award; Blood Vessels; Cell Differentiation process; Cell Lineage; Cells; Cellular biology; Clinical; Collaborations; Colorado; Core Facility; Development; Disease; Faculty; Funding; Goals; Health; Hematological Disease; Hematopoietic; Hematopoietic stem cells; Institutes; Lung; Lung diseases; Mentors; Methods; National Heart, Lung, and Blood Institute; Reagent; Recruitment Activity; Regenerative Medicine; Research; Research Training; Science; Skin; Stem cells; Therapeutic; Time; Training Programs; Translational Research; Translations; Universities; Viral; discount; follower of religion Jewish; improved; induced pluripotent stem cell; member; new technology; novel; programs; stem; stem cell biology

DESCRIPTION (provided by applicant): This application proposes to establish the Denver Network of the NHLBI Progenitor Cell Biology Consortium. The timing of this RFA coincides perfectly with new a multi-institutional stem cell initiative in Denver. A new Regenerative Medicine and Stem Cell Biology Program (RMSCBP) was established at the University of Colorado Denver (UCD) in 2007, which has resulted in the recruitment of 7 new faculty whose research efforts focus on stem cell biology. In concert with this initiative, National Jewish Health (NJH) recruited two outstanding lung stem cell biologists. These new recruits have joined 24 existing faculty to form a multi-institutional, comprehensive stem cell program consisting of over 30 primary members who have access to state-of-the-art Core Facilities at discounted rates (http://www.uchsc.edu/stemcell/). The projects proposed in this application are excellent examples of existing collaborations that were initiated within the last year as a result of these new stem cell initiatives. Specifically, this application proposes to utilize the existing expertise within the Denver Network in the areas of hematopoietic and skin stem cell biology to generate improved reagents to identify and characterize lung and vascular progenitor cell lineages. In addition, to facilitate the development of new methods for isolating lung and vascular stem and progenitor cells, and for directing the differentiation of these cells to desired cell fates, we propose to establish new Core Facilities which utilize novel technologies developed by members of the Denver Network. Finally, the therapeutic potential of conditionally immortalized long-term hematopoietic stem cells and induced pluripotent stem (iPS) cells, which will be generated by novel non-viral methods, will be explored for the treatment of hematological and lung disorders. The translational and clinical aspects of this application, as well as the proposed mentoring and training program, will be greatly facilitated by the Colorado Clinical Translational Science Institute (CCTSI). The clinical and translation sciences, research, and training at UCD and its six Affiliates, which includes NJH, were recently successfully integrated into the CCTSI following the receipt of a CTSA award of $76 million.

描述（由申请人提供）：本申请提议建立 NHLBI 祖细胞生物学联盟的丹佛网络。这次 RFA 的时间恰逢丹佛新的多机构干细胞计划。 2007 年，科罗拉多大学丹佛分校 (UCD) 设立了一个新的再生医学和干细胞生物学项目 (RMSCBP)，招募了 7 名新的教师，他们的研究重点是干细胞生物学。为了配合这一举措，国家犹太健康中心 (NJH) 招募了两名杰出的肺干细胞生物学家。这些新招募的人员与 24 名现有教员一起组成了一个多机构、综合的干细胞计划，由 30 多名主要成员组成，他们可以以折扣价使用最先进的核心设施 (http://www.uchsc.edu/stemcell/)。本申请中提出的项目是去年由于这些新的干细胞计划而启动的现有合作的优秀例子。具体来说，该申请建议利用丹佛网络在造血和皮肤干细胞生物学领域的现有专业知识来生成改进的试剂来识别和表征肺和血管祖细胞谱系。此外，为了促进分离肺和血管干细胞和祖细胞的新方法的开发，并指导这些细胞分化为所需的细胞命运，我们建议建立新的核心设施，利用丹佛网络成员开发的新技术。最后，将探索通过新型非病毒方法产生的条件永生化长期造血干细胞和诱导多能干细胞（iPS）用于治疗血液和肺部疾病的治疗潜力。科罗拉多州临床转化科学研究所 (CCTSI) 将极大地促进该应用程序的转化和临床方面以及拟议的指导和培训计划。 UCD 及其六家附属机构（包括 NJH）的临床和翻译科学、研究和培训最近在获得 CTSA 7600 万美元的奖励后成功并入 CCTSI。