Magnetic Resonance Imaging of Carotid Artery Subclincal Atherosclerosis

颈动脉亚临床动脉粥样硬化的磁共振成像

基本信息

  • 批准号:
    7781402
  • 负责人:
  • 金额:
    $ 13.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-03-06 至 2014-02-28
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Jarett D. Berry, MD, has received an appointment effective July, 2008 in the Department of Preventive Medicine (primary) and the Department of Medicine, Division of Cardiology (secondary) at Northwestern University. The candidate's long-term goal is to combine a career in cardiovascular medicine with research independence in the study of plaque characterization using magnetic resonance imaging (MRI) methods in population studies. The candidate's previous research experience in cardiovascular disease epidemiology has focused on alternative statistical modeling strategies for risk estimation. Emerging imaging methods such as carotid MRI can accurately quantify and characterize plaque burden (i.e. "the vulnerable plaque"). However, it remains unclear exactly how to incorporate plaque imaging data into clinical decision-making because little is known regarding its association with traditional risk factors across the lifespan. The proposed career development plan incorporates advanced training in biomedical engineering, MRI image acquisition, MRI image analysis, and data analysis through a combination of structured coursework, seminars, and training experiences. The present proposal is an ancillary study to an existing NHLBI-funded study, the "Chicago Healthy Aging Study" (CHAS) in which individuals with risk factors measured at age 25- 44 years in the 1960s will be reexamined for the presence of coronary calcium, inflammation, and physical functioning decades later at ages 65-79 years. Because risk factors were measured in these participants at a young age, the addition of carotid MRI measures to the CHAS provides a unique and cost-effective opportunity to compare the association between risk factors measured at ages 25-44 years and carotid MRI plaque characteristics at age 65-79 years. The primary specific aims include: (1) to determine the association of low-risk (LR) status at ages 25-44 years with MRI measures of carotid atherosclerosis at ages 65-79 years; (2) to determine the association of MRI measures of carotid atherosclerosis measured at ages 65-79 years with concurrent measures of subclinical atherosclerosis in the coronary and peripheral arterial beds. This research will fill critical gaps in our knowledge of the long-term consequences of LR status, which may ultimately lead to improvements in public health and preventive strategies.
描述(由申请人提供):

项目成果

期刊论文数量(0)
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Jarett D Berry其他文献

Jarett D Berry的其他文献

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{{ truncateString('Jarett D Berry', 18)}}的其他基金

Characterization of Mechanisms of Exercise Intolerance in Patients at Risk for Heart Failure with Preserved Ejection Fraction
射血分数保留的心力衰竭风险患者运动不耐受机制的特征
  • 批准号:
    10570802
  • 财政年份:
    2023
  • 资助金额:
    $ 13.22万
  • 项目类别:
Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
膳食磷酸盐过量对运动能力和内脏肥胖的影响
  • 批准号:
    10597140
  • 财政年份:
    2022
  • 资助金额:
    $ 13.22万
  • 项目类别:
Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
膳食磷酸盐过量对运动能力和内脏肥胖的影响
  • 批准号:
    10464465
  • 财政年份:
    2022
  • 资助金额:
    $ 13.22万
  • 项目类别:
Biomarkers of myocardial injury, blood pressure and cardiovascular outcomes in SPRINT
SPRINT 中心肌损伤、血压和心血管结局的生物标志物
  • 批准号:
    9759983
  • 财政年份:
    2018
  • 资助金额:
    $ 13.22万
  • 项目类别:
Biomarkers of myocardial injury, blood pressure and cardiovascular outcomes in SPRINT
SPRINT 中心肌损伤、血压和心血管结局的生物标志物
  • 批准号:
    9926727
  • 财政年份:
    2018
  • 资助金额:
    $ 13.22万
  • 项目类别:
Biomarkers of myocardial injury, blood pressure and cardiovascular outcomes in SPRINT
SPRINT 中心肌损伤、血压和心血管结局的生物标志物
  • 批准号:
    9615347
  • 财政年份:
    2018
  • 资助金额:
    $ 13.22万
  • 项目类别:
Magnetic Resonance Imaging of Carotid Artery Subclincal Atherosclerosis
颈动脉亚临床动脉粥样硬化的磁共振成像
  • 批准号:
    7588470
  • 财政年份:
    2009
  • 资助金额:
    $ 13.22万
  • 项目类别:
Magnetic Resonance Imaging of Carotid Artery Subclincal Atherosclerosis
颈动脉亚临床动脉粥样硬化的磁共振成像
  • 批准号:
    8215922
  • 财政年份:
    2009
  • 资助金额:
    $ 13.22万
  • 项目类别:
Magnetic Resonance Imaging of Carotid Artery Subclincal Atherosclerosis
颈动脉亚临床动脉粥样硬化的磁共振成像
  • 批准号:
    8432043
  • 财政年份:
    2009
  • 资助金额:
    $ 13.22万
  • 项目类别:
Magnetic Resonance Imaging of Carotid Artery Subclincal Atherosclerosis
颈动脉亚临床动脉粥样硬化的磁共振成像
  • 批准号:
    8044060
  • 财政年份:
    2009
  • 资助金额:
    $ 13.22万
  • 项目类别:

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