权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

膳食磷酸盐过量对运动能力和内脏肥胖的影响

基本信息

批准号：
10597140
负责人：
Jarett D Berry
金额：
$ 80.53万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10597140
关键词：
ATP Synthesis Pathway Accelerometer Adult Ancillary Study Animals Attenuated Basal metabolic rate Bread Chronic Kidney Failure Circulation Consumption Cross-Over Studies Cross-Over Trials Data Diet Dietary Practices Dietary Questionnaires Dietary intake Down-Regulation Energy Intake Etiology Excretory function Exercise Fatty Acids Fatty acid glycerol esters Food Food Additives Freezing Funding Gene Expression Profile General Population Genes Health Heart Human Impairment Insulin Resistance Intake Knowledge Liver Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Meat Metabolic Metabolism Mitochondria Motor Activity Mus Muscle Muscle Mitochondria Nutritional Obesity Oxygen Participant Pathogenicity Physical activity Pilot Projects Process Public Health Randomized Recommendation Recommended Daily Allowances Rest Risk Factors Series Serum Skeletal Muscle Testing Theoretical model Visceral Visceral fat Work adverse outcome animal data carbohydrate metabolism cardiometabolic risk cardiometabolism cardiorespiratory fitness cardiovascular health clinical practice dietary dietary excess evidence based guidelines exercise capacity exercise intolerance fast food fatty acid oxidation fibroblast growth factor 23 food preparation in vivo inorganic phosphate mitochondrial dysfunction oxidation primary outcome prospective respiratory secondary outcome soft drink translational study trend uptake urinary

项目摘要

Project Summary/Abstract Inorganic phosphate (Pi) is used in excess as a preservative and flavor enhancement in processed foods. Accordingly, 25% US adult consume Pi at 3-4 fold higher than the recommended daily allowance on a regular basis. While the impact of dietary Pi excess in the setting of chronic kidney disease has been well- studied, its impact on human health in the general population remains incompletely understood. Our recent study in mice demonstrated that dietary Pi loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. These metabolic changes were related to downregulation of numerous genes involved in fatty acid release, transport, and oxidation. Furthermore, our pilot study from the third examination of the Dallas Heart Study (DHS-3) provided support for the animal data as a robust association between higher dietary Pi intake and lower in vivo mitochondrial function using 7-Tesla 31P magnetic resonance spectroscopy and oxygen uptake during exercise was observed. More importantly, an association between higher dietary Pi intake and markers of insulin resistance, including higher liver and muscle fat content was uncovered. Therefore, we propose an ancillary study to the already funded 3rd examination of the DHS to test the impact of dietary Pi excess on physical activity and cardiorespiratory fitness. We will also conduct a randomized crossover study to determine if this phosphotoxicity on the muscle mitochondrial function and exercise capacity is restored by lowering dietary Pi content, which is independent of total energy intake and other nutritional components. The proposed translational studies in otherwise healthy humans have the potential to shift current clinical practice paradigms by identifying phosphate as a key modifiable cardiometabolic risk factor in the general population.

项目总结/文摘