Magnetic Resonance Imaging of Carotid Artery Subclincal Atherosclerosis

颈动脉亚临床动脉粥样硬化的磁共振成像

• 批准号: 8044060
• 负责人: Jarett D Berry
• 金额: $ 13.24万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-06 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8044060
• 关键词: Acute; Adult; Age; Ancillary Study; Ankle; Appointment; Area; Arterial Fatty Streak; Atherosclerosis; Attention; Beds; Berry; Biomedical Engineering; Blood; Calcified; Calcium; Cardiology; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Carotid Artery Plaques; Carotid Atherosclerotic Disease; Characteristics; Chicago; Cholesterol; Clinical; Clinical Research; Cohort Studies; Complex; Coronary; Coronary artery; Data; Data Analyses; Data Collection; Data Quality; Detection; Development; Development Plans; Diabetes Mellitus; Epidemiologic Studies; Epidemiology; Event; Funding; Goals; Heart; Image; Image Analysis; Individual; Industry; Inflammation; Internal carotid artery structure; Knowledge; Lead; Life; Lipids; Longevity; Magnetic Resonance Imaging; Measures; Medicine; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Observational Study; Outcome; Participant; Pattern; Performance; Peripheral; Persons; Physical Function; Plague; Population Study; Prevention strategy; Preventive Medicine; Process; Public Health; Relative (related person); Research; Research Design; Research Personnel; Resolution; Risk; Risk Factors; Smoking; Source; Statistical Models; Stenosis; Structure; Thick; Time; Tissues; Training; United States; Universities; Walking; aged; arterial remodeling; calcification; career; career development; clinical decision-making; cost effective; design; experience; healthy aging; high risk; imaging modality; in vivo; indexing; intima media; middle age; mortality; novel; novel strategies; prospective; protective effect; racial difference; young adult

DESCRIPTION (provided by applicant): Jarett D. Berry, MD, has received an appointment effective July, 2008 in the Department of Preventive Medicine (primary) and the Department of Medicine, Division of Cardiology (secondary) at Northwestern University. The candidate's long-term goal is to combine a career in cardiovascular medicine with research independence in the study of plaque characterization using magnetic resonance imaging (MRI) methods in population studies. The candidate's previous research experience in cardiovascular disease epidemiology has focused on alternative statistical modeling strategies for risk estimation. Emerging imaging methods such as carotid MRI can accurately quantify and characterize plaque burden (i.e. "the vulnerable plaque"). However, it remains unclear exactly how to incorporate plaque imaging data into clinical decision-making because little is known regarding its association with traditional risk factors across the lifespan. The proposed career development plan incorporates advanced training in biomedical engineering, MRI image acquisition, MRI image analysis, and data analysis through a combination of structured coursework, seminars, and training experiences. The present proposal is an ancillary study to an existing NHLBI-funded study, the "Chicago Healthy Aging Study" (CHAS) in which individuals with risk factors measured at age 25- 44 years in the 1960s will be reexamined for the presence of coronary calcium, inflammation, and physical functioning decades later at ages 65-79 years. Because risk factors were measured in these participants at a young age, the addition of carotid MRI measures to the CHAS provides a unique and cost-effective opportunity to compare the association between risk factors measured at ages 25-44 years and carotid MRI plaque characteristics at age 65-79 years. The primary specific aims include: (1) to determine the association of low-risk (LR) status at ages 25-44 years with MRI measures of carotid atherosclerosis at ages 65-79 years; (2) to determine the association of MRI measures of carotid atherosclerosis measured at ages 65-79 years with concurrent measures of subclinical atherosclerosis in the coronary and peripheral arterial beds. This research will fill critical gaps in our knowledge of the long-term consequences of LR status, which may ultimately lead to improvements in public health and preventive strategies.

描述（由申请人提供）： 医学博士Jarett D. Berry已于2008年7月在预防医学系（小学）和西北大学心脏病学（中学）的医学系任命。候选人的长期目标是将心血管医学领域的职业与研究独立性相结合，在人群研究中使用磁共振成像（MRI）方法研究牙菌斑表征。候选人以前在心血管疾病流行病学方面的研究经验集中在替代性统计建模策略上，以进行风险估计。诸如颈动脉MRI之类的新兴成像方法可以准确地量化和表征斑块负担（即“弱势斑块”）。但是，尚不清楚如何将斑块成像数据纳入临床决策中，因为它与整个生命周期中传统风险因素的关联知之甚少。拟议的职业发展计划结合了生物医学工程，MRI图像获取，MRI图像分析和数据分析的高级培训，结合了结构化课程，研讨会和培训经验。本提案是对现有NHLBI资助的研究的辅助研究，即“芝加哥健康老化研究”（CHAS），在1960年代，具有25至44岁危险因素的个体将在数十年以后的65 - 79年以后的冠状动脉钙，炎症，炎症，炎症，炎症，炎症和身体功能进行重新检查。由于在年轻的参与者中测量了危险因素，因此在CHAS中加入颈动脉MRI措施提供了一个独特而成本效益的机会，以比较25-44岁的25-44岁的风险因素与65-79岁年龄段的Carotid MRI Plaque特征之间的危险因素之间的关联。主要特定目的包括：（1）确定25-44岁年龄段的低风险（LR）状态与65-79岁的颈动脉粥样硬化的MRI测量； （2）确定在65-79岁时测量的颈动脉粥样硬化的MRI测量，并同时测量冠状动脉和外围动脉床中亚临床动脉粥样硬化。这项研究将填补我们对LR状态的长期后果的了解，这最终可能导致公共卫生和预防策略的改善。