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Atherosclerosis and Inflammation in HIV Disease

HIV 疾病中的动脉粥样硬化和炎症

基本信息

批准号：
7914065
负责人：
Janet Lo
金额：
$ 14.16万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-02 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7914065
关键词：
Adipose tissue Age Angiography Anti-Retroviral Agents Arterial Fatty Streak Atherosclerosis Attenuated Biology Biometry C-reactive protein CD4 Positive T Lymphocytes CD8-Positive T-Lymphocytes CD8B1 gene Cardiac Cardiology Cardiovascular Diseases Cardiovascular system Categories Cells Cholesterol Chronic Coenzyme A Combined Modality Therapy Communities Coronary Coronary Arteriosclerosis Cytotoxic T-Lymphocytes Development Diabetes Mellitus Discipline Disease Drug or chemical Tissue Distribution Dyslipidemias Endocrinology Environment Event Excess Mortality Fatty acid glycerol esters Future General Population Glucose Metabolism Disorders Goals Grant HIV HIV Infections Health Services Accessibility Hyperinsulinism Image Immune System Diseases Individual Infection Inflammation Inflammatory Insulin Resistance Interferons K-Series Research Career Programs Lead Link Measures Medicine Mentors Mentorship Metabolic Oxidoreductase Patients Physiological Placebo Control Placebos Play Population Pravastatin Prevalence Prevention Prevention strategy Production Randomized Recruitment Activity Research Research Personnel Risk Risk Factors Role Slice Smoke T cell response T-Cell Activation T-Lymphocyte T-Lymphocyte Subsets Translational Research Virus Diseases Visceral X-Ray Computed Tomography abstracting blood glucose regulation burden of illness cardiovascular risk factor career development cohort design detector fluorodeoxyglucose positron emission tomography immune function improved inhibitor/antagonist monocyte novel patient oriented patient population prevent programs response skills transcription factor treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Survival of HIV-infected patients worldwide has remarkably improved with the use of anti-retroviral therapy. Metabolic and cardiovascular complications associated with HIV infection and its treatment are becoming more evident as this patient population ages with chronic viral infection. Metabolic and inflammatory changes in HIV-infected patients including dyslipidemia, insulin resistance, fat redistribution with abnormal adipocytokine secretion, alterations in monocyte subsets, and T-cell activation may increase the risk of atherosclerotic disease. The aims of the proposed grant are: 1) to determine the prevalence and degree of subclinical coronary atherosclerosis using CT angiography in patients with HIV compared to agematched control subjects without HIV infection, 2) to examine risk factors for coronary atherosclerosis in HIV patients, specifically evaluating the potential roles of adipocytokines, monocyte subsets, and T cell activation in atherosclerosis development, and 3) to perform a randomized, placebo-controlled, physiologic study in HIV patients with subclinical coronary atherosclerosis comparing the effects of statin therapy vs. placebo on plaque inflammation (as determined by 18F-fluorodeoxyglucose positron emission tomography), inhibition of plaque progression (as determined by coronary CT angiography), monocyte subsets and T cell response. Characterization of the atherosclerotic disease burden as well as identification of risk factors associated with atherosclerotic disease in HIV will be instrumental to guide the future design of appropriate prevention and treatment strategies for the HIV patient population. To achieve these aims, the candidate will be mentored by internationally recognized experts from several relevant disciplines in patient-oriented and translational research, endocrinology, cardiology, inflammation biology, HIV medicine, cardiac imaging, and biostatistics. Their mentorship and the strength of the candidate's institutional support will provide a well-suited academic environment to conduct this research and to nurture the candidate's career development. This K23 career development award will help the candidate to acquire the additional research skills to achieve her goal of becoming an independent patientoriented translational investigator. (End of Abstract)

描述（由申请人提供）：