The Impact of Indoor Particulate Matter Exposure on Non-Allergic Asthma

室内颗粒物暴露对非过敏性哮喘的影响

基本信息

  • 批准号:
    7885269
  • 负责人:
  • 金额:
    $ 19.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-08-15 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant) Asthma is a chronic inflammatory disease of the lungs that is influenced by a combination of host susceptibility and environmental exposures. Particulate air pollution is a pro-inflammatory agent that has been associated with adverse health consequences. While much research has focused on outdoor exposures, the indoor environment is critical as Americans spend most of their time indoors and the investigators' preliminary data have demonstrated that indoor PM concentrations greatly exceed outdoor PM concentrations in urban homes. Based on preliminary data that suggest a strong association between coarse PM exposure and respiratory symptoms among those with non-allergic asthma, the investigators hypothesize that exposure to indoor coarse PM promotes inflammation and worsening of respiratory symptoms and lung function among individuals with non-allergic asthma. Using a study design that combines a longitudinal panel study and an exposure challenge model, the investigators will aim to provide evidence of a causal relationship between indoor coarse PM exposure and exacerbation of asthma status. In specific aim 1, they will determine the effect of indoor coarse PM exposure on asthma health by conducting an epidemiologic panel study measuring in-home PM concentrations and corresponding daily variation in lung function, asthma symptoms, and biomarkers of inflammation among inner-city minority children with non-allergic asthma. In specific aim 2, they will investigate the short-term effects of coarse PM exposure on non-allergic asthma by administering a controlled, nebulized PM challenge and measuring airway reactivity and biomarkers of inflammation. Completion of the proposed research, along with complementary training and mentorship in an outstanding and supportive environment for clinical research, will provide in-depth exposure to clinical research design, conduct, and analysis. These experiences will allow the principal investigator to become a successful, independent investigator in academic medicine. Asthma affects more than 20 million individuals in the U.S, including over 6 million children and young adults. The proposed research investigates the effect of an environmental exposure, air pollution, on this disease process. If indoor exposure to airborne PM triggers asthma exacerbations and stimulates an inflammatory response, the findings from this study may direct new therapeutic interventions and will represent an important advancement in the treatment of asthma with profound public policy implications.
描述(由申请人提供)

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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MEREDITH C MCCORMACK其他文献

DISPARITIES IN TREATMENT AMONG PATIENTS DISCHARGING AGAINST MEDICAL ADVICE AFTER EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
  • DOI:
    10.1016/j.chest.2023.07.3250
  • 发表时间:
    2023-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    JOHN BREMS;APARNA BALASUBRAMANIAN;NIRUPAMA PUTCHA;ASHRAF FAWZY;NADIA N HANSEL;ROBERT A WISE;MEREDITH C MCCORMACK
  • 通讯作者:
    MEREDITH C MCCORMACK
NEIGHBORHOOD DISADVANTAGE IS ASSOCIATED WITH WORSE LUNG FUNCTION AND HIGHER MORTALITY IN SARCOIDOSIS
  • DOI:
    10.1016/j.chest.2023.07.2007
  • 发表时间:
    2023-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    ALI M MUSTAFA;CAMERON PULLEN;KEVIN PSOTER;MEREDITH C MCCORMACK;ROBERT A WISE;MICHELLE SHARP
  • 通讯作者:
    MICHELLE SHARP
REDUCED CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATIONS AFTER SWITCH FROM DUAL THERAPY TO SINGLE-INHALER TRIPLE THERAPY IN A REAL-WORLD HEALTH CARE SETTING IN THE US
  • DOI:
    10.1016/j.chest.2023.07.3204
  • 发表时间:
    2023-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    MEREDITH C MCCORMACK;STEPHEN G NOORDUYN;NOELLE GRONROOS;LYDIA (YEJIN) LEE;MARY JOHNSON;KRISTIN WROBLESKI;PHANI VEERANKI;AFISI S ISMAILA;EMMELINE IGBOEKWE;ROSIRENE PACZKOWSKI
  • 通讯作者:
    ROSIRENE PACZKOWSKI

MEREDITH C MCCORMACK的其他文献

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{{ truncateString('MEREDITH C MCCORMACK', 18)}}的其他基金

Metformin IN Asthma for overweight and obese individuals (MINA)
二甲双胍用于超重和肥胖人群的哮喘治疗 (MINA)
  • 批准号:
    10740950
  • 财政年份:
    2023
  • 资助金额:
    $ 19.18万
  • 项目类别:
Environmental Determinants of Sleep Disparities and the Consequences for Low Income Children with Asthma
睡眠差异的环境决定因素以及低收入哮喘儿童的后果
  • 批准号:
    10683760
  • 财政年份:
    2021
  • 资助金额:
    $ 19.18万
  • 项目类别:
Translation Core
翻译核心
  • 批准号:
    10532212
  • 财政年份:
    2021
  • 资助金额:
    $ 19.18万
  • 项目类别:
Environmental Determinants of Sleep Disparities and the Consequences for Low Income Children with Asthma
睡眠差异的环境决定因素以及低收入哮喘儿童的后果
  • 批准号:
    10469620
  • 财政年份:
    2021
  • 资助金额:
    $ 19.18万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10306990
  • 财政年份:
    2021
  • 资助金额:
    $ 19.18万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10532202
  • 财政年份:
    2021
  • 资助金额:
    $ 19.18万
  • 项目类别:
Environmental Determinants of Sleep Disparities and the Consequences for Low Income Children with Asthma
睡眠差异的环境决定因素以及低收入哮喘儿童的后果
  • 批准号:
    10214161
  • 财政年份:
    2021
  • 资助金额:
    $ 19.18万
  • 项目类别:
Clean Air- Heart: Clinical trial of an air purifier intervention to reduce indoor particulate matter and improve cardiovascular outcomes in COPD
清洁空气-心脏:空气净化器干预措施减少室内颗粒物并改善慢性阻塞性肺病心血管结局的临床试验
  • 批准号:
    9115166
  • 财政年份:
    2015
  • 资助金额:
    $ 19.18万
  • 项目类别:
Health Effects of Extreme Heat among Vulnerable Populations with Asthma and COPD
极端高温对哮喘和慢性阻塞性肺病易感人群的健康影响
  • 批准号:
    8473337
  • 财政年份:
    2013
  • 资助金额:
    $ 19.18万
  • 项目类别:
Health Effects of Extreme Heat among Vulnerable Populations with Asthma and COPD
极端高温对哮喘和慢性阻塞性肺病易感人群的健康影响
  • 批准号:
    8729486
  • 财政年份:
    2013
  • 资助金额:
    $ 19.18万
  • 项目类别:

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