Environmental Determinants of Sleep Disparities and the Consequences for Low Income Children with Asthma
睡眠差异的环境决定因素以及低收入哮喘儿童的后果
基本信息
- 批准号:10214161
- 负责人:
- 金额:$ 74.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectAfrican AmericanAirAir PollutantsAir PollutionAllergensAsthmaBacteriaBaltimoreBedsBiologicalBiological MarkersChildChildhoodChildhood AsthmaChronic DiseaseCitiesCollectionDataDustEcologyEmergency SituationEnvironmentEnvironmental ExposureEnvironmental MonitoringEpidemiologyExposure toFoundationsGoalsHealthHigh PrevalenceHomeHome environmentHospitalizationHouseholdIndividualIndoor Air QualityIndoor environmentInflammationInflammatoryInterventionLinkLiquid substanceLiteratureLow incomeLungMeasuresMediatingMediator of activation proteinMedicineMicrobeMicrobiologyMonitorMorbidity - disease rateNasal EpitheliumNeeds AssessmentNeighborhoodsNitrogen DioxideNocturnal AsthmaNoseOutcomeOxidative StressParticulate MatterPatient Self-ReportProteinsQuestionnairesReportingResearchRiskSeveritiesSleepSleep Apnea SyndromesSpirometryStaphylococcus aureusSymptomsThailandTimeVisitWorkWorld Health Organizationactigraphyair monitoringairway inflammationambient air pollutionbiological adaptation to stresscockroach allergendesigndisparity reductionenvironmental interventionenvironmental tobacco smokeexperiencefollow-uphealth disparityhousehold environmental exposureindoor particulate matterinner citymicrobialmouse allergenmultidisciplinarypoor sleeppulmonary functionreduce symptomssleep qualitytherapeutic targettherapy designurban setting
项目摘要
Asthma and sleep disordered breathing (SDB) are common chronic diseases that
disproportionately affect Black children and those living in poor neighborhoods. Household
environmental exposures have been shown to increase asthma morbidity and there is strong
biologic rationale that these will impact sleep quality, but to date, there have been limited studies
of the indoor environment and sleep. Our overarching goal is to define home environmental
determinants of sleep disparities and the contribution of sleep disparities to childhood asthma
morbidity among low-income, predominantly Black children living in Baltimore City. The home
environment is critical as children spend the majority of their time indoors, most in their own home
and ~1/3 in the bedroom, the environment most relevant for sleep. We propose to
comprehensively study the bedroom environment, including air quality, allergens, microbes, and
the relationship with sleep quality in children with asthma. Our prior studies have shown that
children in Baltimore City live in homes where bedroom levels of air pollution are three times the
concentrations recommend by the World Health Organization Indoor Air Quality standards and
that mouse allergen, present in high concentrations, is a driver of asthma morbidity in Baltimore.
Bedroom dust and nasal carriage of Staphylococcus aureus are prevalent, and emerging
evidence suggests bedroom exposure to this bacteria and its toxic protein products are
associated with nocturnal asthma. There is biological plausibility that the bedroom environmental
exposures increase inflammation and oxidative stress responses in the upper airway that
contribute to risk for and severity of SDB. While there is emerging evidence that environmental
exposures impact sleep, there is a need for studies with objective assessments in children. Our
research team has extensive experience in the conduct of home environmental monitoring and
simultaneously assessing health outcomes in children. In the proposed project, we aim to
determine the association between a) bedroom environmental exposures (air quality, allergens,
microbes) and sleep quality among children with asthma in Baltimore City 2) bedroom
environmental exposures and upper airway inflammation/oxidative stress 3) sleep quality and
asthma morbidity among children with asthma in Baltimore City. This comprehensive study of
bedroom environment and sleep among inner-city African American children has the potential to
provide foundational evidence for environmental drivers of poor sleep quality that are needed to
design interventions to reduce sleep and asthma health disparities.
哮喘和睡眠呼吸障碍(SDB)是常见的慢性疾病,
对黑人儿童和生活在贫困社区的儿童的影响不成比例。家庭
环境暴露已被证明会增加哮喘发病率,
生物学原理认为这些会影响睡眠质量,但迄今为止,研究有限
室内环境和睡眠。我们的首要目标是定义家庭环境
睡眠差异的决定因素及睡眠差异对儿童哮喘的影响
发病率低收入,主要是黑人儿童生活在巴尔的摩市。家庭
环境是至关重要的,因为孩子们大部分时间都在室内,大多数是在自己家里
约1/3在卧室,这是与睡眠最相关的环境。我们建议
全面研究卧室环境,包括空气质量,过敏原,微生物,
哮喘儿童睡眠质量的关系。我们之前的研究表明,
巴尔的摩市的儿童居住在卧室空气污染水平是
世界卫生组织室内空气质量标准推荐的浓度,
在巴尔的摩,高浓度的老鼠过敏原是哮喘发病率的驱动因素。
居室灰尘和鼻腔携带的金黄色葡萄球菌普遍存在,并不断出现
有证据表明,卧室接触这种细菌及其有毒蛋白质产物,
与夜间哮喘有关。卧室环境有生物相容性
暴露会增加上呼吸道的炎症和氧化应激反应,
有助于SDB的风险和严重程度。虽然有新的证据表明,环境
暴露影响睡眠,需要对儿童进行客观评估的研究。我们
研究团队在家庭环境监测方面拥有丰富的经验,
同时评估儿童的健康状况。在建议的项目中,我们的目标是
确定a)卧室环境暴露(空气质量,过敏原,
在巴尔的摩市的卧室里,哮喘儿童的睡眠质量和呼吸道细菌的数量
环境暴露和上呼吸道炎症/氧化应激3)睡眠质量和
巴尔的摩市儿童哮喘发病率这项对
内城非裔美国儿童的卧室环境和睡眠有可能
为睡眠质量差的环境驱动因素提供基础证据,
设计干预措施,以减少睡眠和哮喘健康差异。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MEREDITH C MCCORMACK其他文献
DISPARITIES IN TREATMENT AMONG PATIENTS DISCHARGING AGAINST MEDICAL ADVICE AFTER EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
- DOI:
10.1016/j.chest.2023.07.3250 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
JOHN BREMS;APARNA BALASUBRAMANIAN;NIRUPAMA PUTCHA;ASHRAF FAWZY;NADIA N HANSEL;ROBERT A WISE;MEREDITH C MCCORMACK - 通讯作者:
MEREDITH C MCCORMACK
NEIGHBORHOOD DISADVANTAGE IS ASSOCIATED WITH WORSE LUNG FUNCTION AND HIGHER MORTALITY IN SARCOIDOSIS
- DOI:
10.1016/j.chest.2023.07.2007 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
ALI M MUSTAFA;CAMERON PULLEN;KEVIN PSOTER;MEREDITH C MCCORMACK;ROBERT A WISE;MICHELLE SHARP - 通讯作者:
MICHELLE SHARP
REDUCED CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATIONS AFTER SWITCH FROM DUAL THERAPY TO SINGLE-INHALER TRIPLE THERAPY IN A REAL-WORLD HEALTH CARE SETTING IN THE US
- DOI:
10.1016/j.chest.2023.07.3204 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
MEREDITH C MCCORMACK;STEPHEN G NOORDUYN;NOELLE GRONROOS;LYDIA (YEJIN) LEE;MARY JOHNSON;KRISTIN WROBLESKI;PHANI VEERANKI;AFISI S ISMAILA;EMMELINE IGBOEKWE;ROSIRENE PACZKOWSKI - 通讯作者:
ROSIRENE PACZKOWSKI
MEREDITH C MCCORMACK的其他文献
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{{ truncateString('MEREDITH C MCCORMACK', 18)}}的其他基金
Metformin IN Asthma for overweight and obese individuals (MINA)
二甲双胍用于超重和肥胖人群的哮喘治疗 (MINA)
- 批准号:
10740950 - 财政年份:2023
- 资助金额:
$ 74.09万 - 项目类别:
Environmental Determinants of Sleep Disparities and the Consequences for Low Income Children with Asthma
睡眠差异的环境决定因素以及低收入哮喘儿童的后果
- 批准号:
10683760 - 财政年份:2021
- 资助金额:
$ 74.09万 - 项目类别:
Environmental Determinants of Sleep Disparities and the Consequences for Low Income Children with Asthma
睡眠差异的环境决定因素以及低收入哮喘儿童的后果
- 批准号:
10469620 - 财政年份:2021
- 资助金额:
$ 74.09万 - 项目类别:
Clean Air- Heart: Clinical trial of an air purifier intervention to reduce indoor particulate matter and improve cardiovascular outcomes in COPD
清洁空气-心脏:空气净化器干预措施减少室内颗粒物并改善慢性阻塞性肺病心血管结局的临床试验
- 批准号:
9115166 - 财政年份:2015
- 资助金额:
$ 74.09万 - 项目类别:
Health Effects of Extreme Heat among Vulnerable Populations with Asthma and COPD
极端高温对哮喘和慢性阻塞性肺病易感人群的健康影响
- 批准号:
8473337 - 财政年份:2013
- 资助金额:
$ 74.09万 - 项目类别:
Health Effects of Extreme Heat among Vulnerable Populations with Asthma and COPD
极端高温对哮喘和慢性阻塞性肺病易感人群的健康影响
- 批准号:
8729486 - 财政年份:2013
- 资助金额:
$ 74.09万 - 项目类别:
The Impact of Indoor Particulate Matter Exposure on Non-Allergic Asthma
室内颗粒物暴露对非过敏性哮喘的影响
- 批准号:
7885269 - 财政年份:2008
- 资助金额:
$ 74.09万 - 项目类别:
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