Can we integrate cognitive-behavioural and pharmacological theories of anxiety?

我们可以整合焦虑的认知行为和药理学理论吗？

• 批准号: G0501223/1
• 负责人: Catherine Harmer
• 金额: $ 41.36万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0501223%2F1
• 关键词: integrate; cognitive; behavioural; pharmacological; theories

Anxiety disorders are very common, affecting about 20% of the population. Current treatment fall into two broad areas - either involving drug treatment or with psychological therapy (particularly Cognitive Behavioural Therapy: CBT). Although patients often receive a combination of these treatments, the research on each treatment type is typically carried out separately.The current proposal explores how both treatments affect responses to emotional information in patients suffering from panic disorder, using both behavioural measures like facial expression recognition and brain scanning methods. By exploring the effects of both treatment types together we can gain information about their similarities and differences and also how these treatments may affect each other (i.e. perhaps drug treatments improving the effects of CBT, or vice-versa). It is predicted that both treatments will decrease automatic brain responses to threat and reduce dysfunctional beliefs relevant to panic. However, it is hypothesised that the drug treatment will first affect automatic processing of threatening cues with effects on these beliefs emerging later. By contrast, CBT is predicted to directly target beliefs and behaviour which take time to unravel automatic processing biases. This proposal therefore aims to understand the mechanisms underlying two different successful treatments for anxiety disorders. Such an approach may help develop more optimal combinations of drug and psychological therapy.

焦虑症非常普遍，影响了大约20%的人口。目前的治疗分为两大领域--要么是药物治疗，要么是心理治疗(特别是认知行为治疗：CBT)。虽然患者经常接受这些治疗的组合，但对每种治疗类型的研究通常是单独进行的。目前的提案探索了这两种治疗方法如何影响惊恐障碍患者对情绪信息的反应，使用面部表情识别和脑扫描方法等行为测量方法。通过一起探索这两种治疗类型的效果，我们可以了解它们的相似和不同之处，以及这些治疗方法如何相互影响(例如，也许药物治疗可以提高CBT的效果，反之亦然)。据预测，这两种治疗方法都将降低大脑对威胁的自动反应，并减少与恐慌相关的功能失调的信念。然而，假设药物治疗将首先影响威胁线索的自动处理，对这些信念的影响随后出现。相比之下，CBT预计会直接针对信念和行为，而这些信念和行为需要时间来消除自动加工偏见。因此，这项建议旨在了解两种成功治疗焦虑症的不同方法背后的机制。这种方法可能有助于开发药物和心理治疗的更理想组合。