A cognitive vaccine for depression: assessment using neurobiological outcomes in experimental medicine models

抑郁症认知疫苗：在实验医学模型中使用神经生物学结果进行评估

• 批准号: G0701672/1
• 负责人: Catherine Harmer
• 金额: $ 25.47万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701672%2F1
• 关键词: cognitive; vaccine; depression; assessment; using

One of the most debilitating aspects of depression is that it tends to recur in the same people over and over again. In fact if you have had one episode of depression there is an 80% chance you?ll have at least one further episode in your life, and you may have many more. The recurrent nature of depression suggests that certain individuals have a constitutional tendency or ?vulnerability factor? to develop the illness. It?s crucial that we understand what these may be; as if we can treat them we should be able to prevent the depression from recurring. Such a treatment could be thought of as a ?vaccine? against depression.A strong contender for a vulnerability factors for depression is the way peoples? brains handle emotional information. For example there is evidence that people who have been depressed pay more attention to negative information.This processing style would be a particularly promising target for treatment as there is already a simple method for changing it; the ?cognitive bias modification of attention? task (CBMa). CBMa is a simple, computer based task that helps people get in the habit of ignoring negative information. We think that the CBMa task may work as a ?vaccine? against depression.In this project we are going to assess whether it looks like CBMa will prevent recurrent depression. To do this we?re going to perform three studies. All three studies will compare the effects of CBMa with a similar, but inactive, control procedure in people who have previously been depressed. Study 1 will look at the basic effect of CBMa and will provide information about how often it should be carried out. Studies 2 and 3 will gauge how effective CBMa is likely to be in preventing depression by measuring how it affects a range of biological abnormalities which tend to occur in people who have repeated depression. Specifically we will measure the effects of CBMa on:? How much of a hormone called cortisol participants have in their saliva? Which areas of participants? brains are activated by negative pictures? Whether participants? mood drops after the level of serotonin in their brain is reduced using the ?Acute Trypotophan Depletion? procedure. All of these measures will give us information on whether CBMa is likely to reduce recurrence of depression and whether we?re ready to try it out in large scale clinical trials.

抑郁症最令人衰弱的一个方面是，它往往会在同一个人身上反复发作。事实上，如果你有过一次抑郁症发作，你有80%的机会？在你的生活中，至少还会有一个小插曲，你可能还会有更多。抑郁症的复发性表明，某些人有体质倾向或？脆弱性因素？发展成这种疾病是吗？关键是我们要了解这些可能是什么;如果我们能治疗它们，我们就应该能够防止抑郁症复发。这样的治疗可以被认为是一种？疫苗？一个强大的竞争者为抑郁症的脆弱性因素是人们的方式？大脑处理情感信息。例如，有证据表明，抑郁症患者更关注负面信息，这种处理方式将是一个特别有希望的治疗目标，因为已经有一种简单的方法来改变它;注意力的认知偏差修正任务（CBMa）。CBMa是一个简单的，基于计算机的任务，帮助人们养成忽视负面信息的习惯。我们认为，CBMA任务可以作为一个？疫苗？在这个项目中，我们将评估CBMa是否会预防复发性抑郁症。为了做到这一点，我们？我们将进行三项研究。这三项研究都将比较CBMa与类似但不活跃的控制程序对以前患有抑郁症的人的影响。研究1将研究CBMA的基本效果，并提供关于多久进行一次CBMA的信息。研究2和3将通过测量CBMA如何影响一系列倾向于发生在反复抑郁症患者中的生物异常来衡量CBMA在预防抑郁症方面的有效性。具体来说，我们将衡量CBMa对以下方面的影响：？参与者的唾液中有多少叫做皮质醇的激素？哪些领域的参与者？大脑会被负面图片激活吗无论是参与者？情绪下降后，血清素在他们的大脑中的水平是减少使用？急性色氨酸耗竭？procedure.所有这些措施将为我们提供CBMA是否可能减少抑郁症复发的信息，以及我们是否应该采取措施。We’我们准备在大规模的临床试验中进行试验。