Measuring Living Kidney Transplantation at Renal Transplant Centers

测量肾移植中心的活体肾移植情况

• 批准号: 7892561
• 负责人: PETER PHILIP REESE
• 金额: $ 13.17万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892561
• 关键词: Adult; Attention; Biometry; Caring; Case Mixes; Cessation of life; Chronic; Clinical; Complex; Dialysis procedure; End stage renal failure; Environment; Epidemiology; Ethics; Future; Geographic Locations; Health Policy; Hypertension; Incidence; K-Series Research Career Programs; Kidney; Kidney Transplantation; Lead; Life; Living Donors; Marketing; Measures; Medical Ethics; Mentors; National Research Service Awards; Organ; Patients; Pennsylvania; Population; Prevalence; Process; Quality of life; Records; Research; Research Personnel; Resources; Services; Specific qualifier value; Training Programs; Transplant Surgeon; Transplantation; United Network for Organ Sharing; United States; Universities; Variant; cardiovascular risk factor; career; desensitization; experience; improved; indexing; medical schools; mortality; patient oriented research; programs; skills

DESCRIPTION (provided by applicant): Dr. Peter P. Reese, a National Research Service Award Fellow in the Renal Division at the University of Pennsylvania School of Medicine, is applying for a K-23 Patient Oriented Research Career Development Award to acquire further experience and skills for an academic career as an independent investigator focused on transplantation. This proposal outlines a 5-year multi-disciplinary training program consisting of research, coursework, and mentoring by Dr. Harold I. Feldman, Director of the Clinical Epidemology Unit at Penn's Center for Clinical Epidemology and Biostatistics. Dr. Reese will pursue coursework in epidemiology, biostatistics, health policy and medical ethics which pertain directly to his proposed K-23 project, and which will prepare him to lead future independent research programs related to renal transplantation. The prevalence of end-stage renal disease (ESRD) in the United States (US) continues to climb, with devastating consequences for patients including an elevated risk of cardiovascular death and the burden of chronic dialysis. The growing ESRD population has intensified the demand for kidney transplantation, which has been shown to reduce mortality and improve quality of life compared to chronic dialysis. Given a limited supply of deceased donor kidneys, transplant professionals have increasingly focused attention on living kidney transplantation. Maximizing this vital resource for transplant candidates could substantially reduce the burdens of ESRD. Large and unexplained variation exists in the magnitude of living kidney transplantation across renal transplant centers. Comprehensive transplantation records from the United Network of Organ Sharing offer a valuable opportunity to elucidate the factors underlying this variation. Through the proposed project, Dr. Reese will measure magnitude of living kidney transplantation within and across transplant centers, and identify center attributes associated with variation in the magnitude of living kidney transplantation. Understanding how transplant centers optimize or limit their patients' opportunities to obtain a live donor kidney transplant represents a crucial advance in developing strategies to expand access to transplantation overall.

描述（由申请人提供）： 博士Peter P. Reese是宾夕法尼亚大学医学院肾脏科的国家研究服务奖研究员，他正在申请K-23患者导向研究职业发展奖，以获得作为专注于移植的独立研究者的学术生涯的进一步经验和技能。该提案概述了一个为期5年的多学科培训计划，包括研究，课程和指导博士哈罗德我。宾夕法尼亚大学临床流行病学和生物统计学中心临床流行病学部主任费尔德曼说。Reese博士将攻读流行病学，生物统计学，卫生政策和医学伦理学课程，这些课程直接涉及他提出的K-23项目，并将为他领导未来与肾移植相关的独立研究项目做好准备。 美国（US）终末期肾病（ESRD）的患病率持续攀升，给患者带来了毁灭性后果，包括心血管死亡风险升高和慢性透析负担。不断增长的ESRD人口增加了对肾移植的需求，与慢性透析相比，肾移植已被证明可以降低死亡率并改善生活质量。由于死亡供体肾脏的供应有限，移植专业人员越来越关注活体肾脏移植。最大限度地为移植候选人提供这一重要资源可以大大减轻ESRD的负担。 肾移植中心之间的活体肾移植数量存在巨大且无法解释的差异。来自器官共享联合网络的全面移植记录为阐明这种变化的潜在因素提供了宝贵的机会。通过拟议的项目，Reese博士将测量移植中心内和跨移植中心的活体肾移植的规模，并确定与活体肾移植规模变化相关的中心属性。了解移植中心如何优化或限制患者获得活体供肾移植的机会，是制定扩大整体移植机会的战略的关键进展。