High performance motoring - replication fork movement in a complex environment

高性能驾驶 - 在复杂环境中复制叉子运动

基本信息

  • 批准号:
    G0501626/1
  • 负责人:
  • 金额:
    $ 40.47万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Research Grant
  • 财政年份:
    2006
  • 资助国家:
    英国
  • 起止时间:
    2006 至 无数据
  • 项目状态:
    已结题

项目摘要

DNA replication is essential to pass on the genetic blueprint from one generation to the next. Moreover, duplication of DNA must be done with the highest possible accuracy. Even small mistakes arising during the duplication process can lead to the development of genetic disease and cancers in humans. To minimise the possibility of such mistakes being made during DNA replication, all organisms have evolved complex biological machines to perform this process both speedily and accurately. However, recent work has shown that despite the best efforts of evolution, this DNA replication machinery does break down. If not restarted, these breakdowns lead to potentially catastrophic errors arising in the genetic blueprint. We have developed a system to monitor the breakdown of replication using the simple DNA replication apparatus of a bacterium. This current proposal aims to determine the features of replication machines that help minimise their breakdown. But when replication does break down, there are systems that attempt to restart the replication process. We will therefore also try and establish whether the repair systems interact with the replication machinery to help make the repair process more efficient. These studies therefore aim to characterise how organisms minimise the chances of DNA duplication going awry to try and avoid the disastrous consequences of defects arising within the genetic material.
DNA复制对于将遗传蓝图从一代传递到下一代至关重要。此外,DNA的复制必须尽可能精确。即使是复制过程中出现的小错误也可能导致人类遗传疾病和癌症的发展。为了尽量减少在DNA复制过程中出现这种错误的可能性,所有生物都进化出了复杂的生物机器,以快速准确地执行这一过程。然而,最近的研究表明,尽管进化做出了最大的努力,但这种DNA复制机制确实会崩溃。如果不重新启动,这些故障会导致遗传蓝图中出现潜在的灾难性错误。我们已经开发了一个系统,使用细菌的简单DNA复制装置来监测复制的破坏。目前的建议旨在确定有助于减少故障的复制机的功能。但当复制确实发生故障时,有些系统会尝试重新启动复制过程。因此,我们也将尝试并确定修复系统是否与复制机制相互作用,以帮助使修复过程更有效。因此,这些研究旨在探索生物体如何最大限度地减少DNA复制出错的机会,以避免遗传物质中出现缺陷的灾难性后果。

项目成果

期刊论文数量(0)
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Peter McGlynn其他文献

Recombinational repair and restart of damaged replication forks
受损复制叉的重组修复与重启
Acceptability and feasibility of point-of-care CD4 testing on HIV continuum of care in low and middle income countries: a systematic review
  • DOI:
    10.1186/s12913-016-1588-y
  • 发表时间:
    2016-08-02
  • 期刊:
  • 影响因子:
    3.000
  • 作者:
    Minh D. Pham;Paul A. Agius;Lorena Romero;Peter McGlynn;David Anderson;Suzanne M. Crowe;Stanley Luchters
  • 通讯作者:
    Stanley Luchters
Performance of point-of-care CD4 testing technologies in resource-constrained settings: a systematic review and meta-analysis
  • DOI:
    10.1186/s12879-016-1931-2
  • 发表时间:
    2016-10-21
  • 期刊:
  • 影响因子:
    3.000
  • 作者:
    Minh D. Pham;Paul A. Agius;Lorena Romero;Peter McGlynn;David Anderson;Suzanne M. Crowe;Stanley Luchters
  • 通讯作者:
    Stanley Luchters
Dynamical signatures of freezing: stable fluids, metastable fluids, and crystals.
冻结的动力学特征:稳定流体、亚稳态流体和晶体。
The purple bacterial photosynthetic unit
  • DOI:
    10.1007/bf00040996
  • 发表时间:
    1996-05-01
  • 期刊:
  • 影响因子:
    3.700
  • 作者:
    Richard J. Cogdell;Paul K. Fyfe;Stuart J. Barrett;Stephen M. Prince;Andrew A. Freer;Neil W. Isaacs;Peter McGlynn;C. Neil Hunter
  • 通讯作者:
    C. Neil Hunter

Peter McGlynn的其他文献

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{{ truncateString('Peter McGlynn', 18)}}的其他基金

Speeding and stuttering: analysing the dynamics of DNA replication at the single molecule level
加速和口吃:在单分子水平上分析 DNA 复制的动态
  • 批准号:
    BB/K00168X/1
  • 财政年份:
    2013
  • 资助金额:
    $ 40.47万
  • 项目类别:
    Research Grant
Recombination and the clearance of replicative blocks - to bypass or not to bypass?
重组和复制块的清除——绕过还是不绕过?
  • 批准号:
    BB/J014826/1
  • 财政年份:
    2013
  • 资助金额:
    $ 40.47万
  • 项目类别:
    Research Grant
Why does transcription present a major barrier to genome duplication?
为什么转录是基因组复制的主要障碍?
  • 批准号:
    BB/I001859/2
  • 财政年份:
    2012
  • 资助金额:
    $ 40.47万
  • 项目类别:
    Research Grant
Why does transcription present a major barrier to genome duplication?
为什么转录是基因组复制的主要障碍?
  • 批准号:
    BB/I001859/1
  • 财政年份:
    2011
  • 资助金额:
    $ 40.47万
  • 项目类别:
    Research Grant
Avoiding replication trainwrecks - are accessory replicative helicases needed to underpin replication of protein-bound DNA?
避免复制失败——是否需要辅助复制解旋酶来支持蛋白质结合 DNA 的复制?
  • 批准号:
    BB/G005915/1
  • 财政年份:
    2009
  • 资助金额:
    $ 40.47万
  • 项目类别:
    Research Grant
Conflicts between DNA replication fork progression and transcriptional regulation
DNA复制叉进程与转录调控之间的冲突
  • 批准号:
    BB/C008316/1
  • 财政年份:
    2006
  • 资助金额:
    $ 40.47万
  • 项目类别:
    Research Grant

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  • 批准号:
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