Targeted Approaches to Weight Control for Young Adults Grant with RCU Proposal

描述(由申请人提供)：肥胖是一种慢性疾病，与严重的心血管疾病(CVD)发病率和死亡率有关。年轻人体重增加会对心血管疾病危险因素的发展产生不利影响。此外，肥胖者的体重减轻与这些心血管疾病危险因素的减少之间存在明显的关系。不幸的是，年轻人体重增加的风险很高。尽管科学文献包含了许多关于成功的减肥功效研究的报告，但年轻人的代表性通常较低。吸烟是导致发病率和死亡率的主要可预防原因，但戒烟会导致体重显著增加。戒烟路线已被证明可以帮助人们戒烟。然而，据报道，对戒烟后体重增加的担忧是戒烟的一个重要障碍。如果有效的行为减肥计划可以与有效的行为戒烟计划相结合，防止戒烟后体重增加，那么可能会产生巨大的公共健康益处。这种结合减肥/戒烟的计划，对年轻人使用有针对性的干预策略，消除参与障碍，并利用互动技术，应该对这个年龄段有吸引力。到目前为止，这样的联合计划还没有在试图戒烟的年轻、超重和肥胖的吸烟者中进行测试。因此，这项临床试验的目标是开发和测试一种通过互动技术提供的行为减肥干预，该干预可以与有效的戒烟路线(QL)一起使用。为了充分解决以下具体目标，总共需要330名参与者：主要目标：我们假设，与在年轻超重和肥胖吸烟者中单独使用主动戒烟线(对照组)相比，在登记后2年，有效的主动戒烟线加上通过互动技术提供的行为减肥干预(干预组)将显著减轻或防止与戒烟相关的体重增加。次要目标：我们还计划在以下方面评估小组之间的变化：a.)(B)生物化学证实的戒烟；)饮食和饮食行为；以及c.)体力活动。(摘要结束)

DESCRIPTION (provided by applicant): Obesity represents a chronic disease associated with significant cardiovascular disease (CVD) morbidity and mortality. Weight gain in young adults adversely impacts the development of CVD risk factors. Further, there is a clear relationship between weight loss in obese persons and reduction in these CVD risk factors. Unfortunately, young adults are at high risk for weight gain. Although the scientific literature contains a number of reports regarding successful weight loss efficacy studies, young adults are typically underrepresented. Cigarette smoking is the leading preventable cause of morbidity and mortality, but quitting smoking results in significant weight gain. Tobacco quit lines have been shown to help persons quit smoking. However, concerns about post-cessation weight gain have been reported as a significant barrier to quitting. If an efficacious behavioral weight loss program could be combined with an efficacious behavioral smoking cessation program that prevented post-cessation weight gain, then a large public health benefit may result. Such a combined weight loss / smoking cessation program that used targeted intervention strategies to young adults, removed barriers to participation, and utilize interactive technology should be appealing to this age group. To date such a combined program has not been tested in young overweight and obese cigarette smokers trying to quit. Therefore, the objective of this clinical trial is to develop and test a behavioral weight loss intervention delivered through interactive technology that can be used in conjunction with an efficacious tobacco quit line (QL). A total of 330 participants will be necessary to adequately address the following specific aims: Primary Aim: We hypothesize that an efficacious proactive tobacco quit line plus a behavioral weight loss intervention delivered through interactive technology (Intervention Group) will significantly attenuate or prevent weight gain associated with smoking cessation at 2 years after enrollment compared to a proactive tobacco quit line alone (Comparison Group) in young overweight and obese smokers. Secondary Aims: We also plan to assess changes between the groups in: a.) Biochemically verified smoking cessation; b.) Diet and eating behavior; and c.) Physical activity. (End of Abstract)