Targeted Approaches to Weight Control for Young Adults Grant with RCU Proposal

描述（由申请人提供）：肥胖是一种与显著心血管疾病（CVD）发病率和死亡率相关的慢性疾病。年轻人的体重增加对CVD危险因素的发展产生不利影响。此外，肥胖者的体重减轻与这些CVD风险因素的减少之间存在明显的关系。不幸的是，年轻人体重增加的风险很高。虽然科学文献包含了一些关于成功减肥功效研究的报告，但年轻人通常代表性不足。吸烟是发病率和死亡率的主要可预防原因，但戒烟会导致体重显著增加。戒烟热线已被证明可以帮助人们戒烟。然而，据报道，对戒烟后体重增加的担忧是戒烟的一个重要障碍。如果一个有效的行为减肥计划可以与一个有效的行为戒烟计划，防止戒烟后体重增加相结合，那么一个大的公共卫生效益可能会导致。这样一个结合减肥/戒烟的计划，对年轻人使用有针对性的干预策略，消除了参与的障碍，并利用互动技术，应该对这个年龄组有吸引力。到目前为止，这种联合方案还没有在试图戒烟的年轻超重和肥胖吸烟者中进行过测试。因此，本临床试验的目的是开发和测试一种通过互动技术提供的行为减肥干预，该干预可与有效的戒烟线（QL）结合使用。总共需要330名参与者，以充分实现以下具体目标：我们假设，一个有效的主动戒烟线加上行为减肥干预通过互动技术提供与单独的主动戒烟线相比，（干预组）将在入组后2年显著减轻或预防与戒烟相关的体重增加（对照组）在年轻超重和肥胖吸烟者。次要目的：我们还计划评估各组之间的变化：a.）经生物化学验证的戒烟; B.）饮食和饮食行为;以及c.）体力活动。 (End摘要）

DESCRIPTION (provided by applicant): Obesity represents a chronic disease associated with significant cardiovascular disease (CVD) morbidity and mortality. Weight gain in young adults adversely impacts the development of CVD risk factors. Further, there is a clear relationship between weight loss in obese persons and reduction in these CVD risk factors. Unfortunately, young adults are at high risk for weight gain. Although the scientific literature contains a number of reports regarding successful weight loss efficacy studies, young adults are typically underrepresented. Cigarette smoking is the leading preventable cause of morbidity and mortality, but quitting smoking results in significant weight gain. Tobacco quit lines have been shown to help persons quit smoking. However, concerns about post-cessation weight gain have been reported as a significant barrier to quitting. If an efficacious behavioral weight loss program could be combined with an efficacious behavioral smoking cessation program that prevented post-cessation weight gain, then a large public health benefit may result. Such a combined weight loss / smoking cessation program that used targeted intervention strategies to young adults, removed barriers to participation, and utilize interactive technology should be appealing to this age group. To date such a combined program has not been tested in young overweight and obese cigarette smokers trying to quit. Therefore, the objective of this clinical trial is to develop and test a behavioral weight loss intervention delivered through interactive technology that can be used in conjunction with an efficacious tobacco quit line (QL). A total of 330 participants will be necessary to adequately address the following specific aims: Primary Aim: We hypothesize that an efficacious proactive tobacco quit line plus a behavioral weight loss intervention delivered through interactive technology (Intervention Group) will significantly attenuate or prevent weight gain associated with smoking cessation at 2 years after enrollment compared to a proactive tobacco quit line alone (Comparison Group) in young overweight and obese smokers. Secondary Aims: We also plan to assess changes between the groups in: a.) Biochemically verified smoking cessation; b.) Diet and eating behavior; and c.) Physical activity. (End of Abstract)