Targeted Approaches to Weight Control for Young Adults Grant with RCU Proposal

RCU 提案为年轻人提供有针对性的体重控制方法

• 批准号: 7700945
• 负责人: KAREN C JOHNSON
• 金额: $ 73.99万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-17 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7700945
• 关键词: Address; Attenuated; Behavior; Behavioral; Body Weight decreased; Cardiovascular Diseases; Chronic Disease; Cigarette Smoker; Clinical Trials; Development; Diet; Eating Behavior; Enrollment; Grant; Health Benefit; Intervention; Literature; Morbidity - disease rate; Obesity; Overweight; Participant; Persons; Physical activity; Public Health; Reporting; Risk Factors; Smoker; Technology; Testing; Tobacco; Weight Gain; Weight maintenance regimen; abstracting; age group; cardiovascular disorder risk; cigarette smoking; comparison group; group intervention; high risk; mortality; prevent; programs; quitline; sedentary; smoking cessation; weight loss intervention; young adult

DESCRIPTION (provided by applicant): Obesity represents a chronic disease associated with significant cardiovascular disease (CVD) morbidity and mortality. Weight gain in young adults adversely impacts the development of CVD risk factors. Further, there is a clear relationship between weight loss in obese persons and reduction in these CVD risk factors. Unfortunately, young adults are at high risk for weight gain. Although the scientific literature contains a number of reports regarding successful weight loss efficacy studies, young adults are typically underrepresented. Cigarette smoking is the leading preventable cause of morbidity and mortality, but quitting smoking results in significant weight gain. Tobacco quit lines have been shown to help persons quit smoking. However, concerns about post-cessation weight gain have been reported as a significant barrier to quitting. If an efficacious behavioral weight loss program could be combined with an efficacious behavioral smoking cessation program that prevented post-cessation weight gain, then a large public health benefit may result. Such a combined weight loss / smoking cessation program that used targeted intervention strategies to young adults, removed barriers to participation, and utilize interactive technology should be appealing to this age group. To date such a combined program has not been tested in young overweight and obese cigarette smokers trying to quit. Therefore, the objective of this clinical trial is to develop and test a behavioral weight loss intervention delivered through interactive technology that can be used in conjunction with an efficacious tobacco quit line (QL). A total of 330 participants will be necessary to adequately address the following specific aims: Primary Aim: We hypothesize that an efficacious proactive tobacco quit line plus a behavioral weight loss intervention delivered through interactive technology (Intervention Group) will significantly attenuate or prevent weight gain associated with smoking cessation at 2 years after enrollment compared to a proactive tobacco quit line alone (Comparison Group) in young overweight and obese smokers. Secondary Aims: We also plan to assess changes between the groups in: a.) Biochemically verified smoking cessation; b.) Diet and eating behavior; and c.) Physical activity. (End of Abstract)

描述（由申请人提供）：肥胖代表一种与严重心血管疾病（CVD）发病率和死亡率相关的慢性疾病。年轻人体重增加会对CVD危险因素的发展产生不利影响。此外，肥胖者的体重减轻与这些CVD风险因素的减少之间存在明显的关系。不幸的是，年轻人的体重增加风险很高。尽管科学文献包含有关成功减肥效力研究的许多报告，但年轻人通常的代表性不足。吸烟是发病率和死亡率的可预防原因，但戒烟会导致体重增加。烟草戒烟线已被证明可以帮助人们戒烟。但是，据报道，人们对戒断后体重增加的担忧是戒烟的重大障碍。如果可以将有效的行为减肥计划与有效的行为戒烟计划相结合，该计划阻止了过度的体重增加，那么可能会带来巨大的公共健康益处。这种合并的减肥 /戒烟计划，使用有针对性的干预策略向年轻人采用了有针对性的干预策略，消除了参与的障碍以及使用互动技术应吸引这个年龄段。迄今为止，尚未在年轻的超重和肥胖的吸烟者试图戒烟的情况下测试这样的合并计划。因此，该临床试验的目的是开发和测试通过交互式技术提供的行为减肥干预措施，该干预措施可与有效的烟草戒烟线（QL）一起使用。 A total of 330 participants will be necessary to adequately address the following specific aims: Primary Aim: We hypothesize that an efficacious proactive tobacco quit line plus a behavioral weight loss intervention delivered through interactive technology (Intervention Group) will significantly attenuate or prevent weight gain associated with smoking cessation at 2 years after enrollment compared to a proactive tobacco quit line alone (Comparison Group) in young overweight and obese smokers.次要目的：我们还计划评估这些组之间的变化：a。）生物化学验证的戒烟； b。）饮食和饮食行为；和c。）体育锻炼。 （抽象的结尾）