A program of research in cardiovascular genetic epidemiology

心血管遗传流行病学研究计划

• 批准号: G0501942/1
• 负责人: Martin Tobin
• 金额: $ 92.24万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0501942%2F1
• 关键词: program; research; cardiovascular; genetic; epidemiology

High blood pressure affects around 30% of all adults in England. This program, involving researchers from the University of Leicester, and from St. George’s Medical School, aims to identify the genetic causes of high blood pressure. With my collaborators, I will try to identify regions of the human genome and the variants within them that affect blood pressure. We will screen more than half a million points in the genome where key variations occur in 1500 people from the 1958 Birth Cohort. We will build on these findings by studying some genomic regions in detail in the GRAPHIC study, involving 500 Leicestershire families who have had blood pressure measured over a complete 24-hour period. At the same time, I will work with other researchers at the University of Leicester to explore the impact of some common, but poorly-understood, types of structural variation in the human genome. We will also develop powerful new ways of combining all these types of information to identify genes that affect blood pressure. Our aim is to find variations that cause high blood pressure and these findings will improve our understanding of how high blood pressure occurs, and how it can be prevented and treated.

高血压影响了英国约30%的成年人。这项计划涉及来自莱斯特大学和圣乔治医学院的研究人员，旨在确定高血压的遗传原因。与我的合作者，我将尝试确定人类基因组的区域和其中影响血压的变异。我们将在1958年出生队列的1500人中筛选基因组中超过50万个关键变异点。我们将在这些发现的基础上，通过在GRAPHIC研究中详细研究一些基因组区域，涉及500个莱斯特郡家庭，他们在完整的24小时内测量了血压。与此同时，我将与莱斯特大学的其他研究人员合作，探索人类基因组中一些常见但知之甚少的结构变异类型的影响。我们还将开发强大的新方法，将所有这些类型的信息结合起来，以识别影响血压的基因。我们的目标是找到导致高血压的变异，这些发现将提高我们对高血压如何发生以及如何预防和治疗的理解。