Administrative/Budgeting, Biostatistics and Data Integration

行政/认证和生物统计学和数据集成核心将提供集中资助 项目1-3的所有统计支持和分析，以及使用 NAPIS数据库。核心D也将有助于合并研究人员，他们的实验结果， 他们的想法，研究工作的评价，并直接总结努力保持高度 综合方案成果。行政/鉴定和生物统计核心的具体目标， 数据整合的核心是：1）为研究者提供基本的行政和服务（包括 管理项目用品、归档、编写备忘录、会议记录和通信 涵盖所有业务，包括出版物和摘要）。这个核心将为调查人员提供清晰的 科学和行政沟通渠道，以促进团队成员之间的合作， 资源的优先级，并促进影响团队成员的任何问题的解决。2)提供 [（a）与项目调查人员合作， 假设和研究设计;（B）进行和指导数据的统计分析，包括 描述性汇总统计和复杂的推理程序，包括阵列分析;（c）努力 应包括及时审查、质量保证、收集结果的传播 所有项目的调查]。3)组织项目指导委员会的月度会议。这 指导委员会应由项目和核心PI组成。4)为所有人组织计划项目会议 项目成员及其实验室成员。5)组织内部审查委员会会议 如果专家小组应评估计划的有效性和试验进展， 指导、技术方法、统计评价和行政效率。6)组织一次 年度外部审查委员会会议。外部审查委员会成员应审查所有 实验发现和成果，帮助优先调查，审查合作的协调， 并评估研究中出现的概念。7)提供全面的财务审查，会计，和真实的 时间预算分析。这包括报告、口头沟通、审查和前瞻性 支出预测。8)通过天然产物信息整合实验数据 系统（NAPIS）的实时、关系型数据库，它被广泛用于支持天然产物药物 的发现

The Administrative/Budgeting and Biostatistics and Data Integration Core will provide centralized grant administration, and all statistical support and analyses for Projects 1-3, and data management using the NAPIS database. Core D will also serve to amalgamate the investigators, their experimental findings and their ideas, evaluation of research efforts and direct the summary efforts toward maintaining a highly integrated Program outcome. The Specific Aims of the Administrative/Budgeting and Biostatistics Core and Data Integration Core are to: 1) Provide basic administrative and services to the investigators (including the management of project supplies, filing, development of memos, meeting minutes and communications covering all operations, including publications and abstracts). This core will provide investigators with clear lines of scientific and administrative communication to promote collaboration among team members, aid in the prioritization of resources, and facilitate resolution of any problems that affect team members. 2) Provide statistical analyses for all projects, [(a) To collaborate with project investigators in the formulation of hypotheses and study design; (b) To conduct and direct the statistical analysis of data including both descriptive summary statistics and sophisticated inferential procedures, including array analyses; (c) Efforts by the Biostatistics group shall include timely review, quality assurance, dissemination of the results gleaned from investigations in all projects]. 3) Organize monthly meetings of the Program Steering Committee. This Steering committee shall consist of the Project and Core Pis. 4) Organize Program Project meetings for all members of the project and their laboratory members. 5) Organize Internal Review Committee meetings where a panel of experts shall assess the Program effectiveness and experimental progress, research directions, technical approaches, statistical evaluation, and administrative effectiveness. 6) Organize an annual External Review Committee meeting. The members of External Review Committee shall review all experimental findings and outcomes, help prioritize investigations, review the coordination of collaborations, and evaluate concepts that emerge from the studies. 7) Provide overall fiscal review, accounting, and real time budgets analyses. This includes reports, verbal communications, reviews and forward-looking projections on expenditures. 8) Experimental data integration through the Natural Products Information System (NAPIS) real-time, relational database, which is widely used to support natural product drug discovery.