VCU Neuroscience Center Core Grant

描述(由申请人提供)：本申请请求继续支持P30核心中心基金，重点是基于显微镜的生物成像，以支持居住在弗吉尼亚联邦大学的大量NINDS资助的研究人员的需求。以前的申请使首席调查员有机会开发当代生物成像设施，并瞄准其他联邦和非联邦来源，以便继续扩大，同时招聘一名在生物成像领域拥有公认专门知识的核心主任。设备、资源、人员和主任，所有这些都是这项资助申请的直接结果，对NINDS赞助的和其他NIH赞助的在弗吉尼亚联邦大学进行的研究产生了重大影响。这种竞争性的更新需要持续的资源来维护和更新这一高生产率的核心设施，如上所述，它服务于NINDS和整个研究所的神经科学研究人员的需求。如书面所述，本申请寻求技术和行政人员、仪器和资源的支持，以支持持续的培训、教育以及加强数据分析和归档。被要求的工作人员将维护所有仪器，同时继续为参与调查的调查人员及其学生和研究员提供培训。此外，核心工作人员将参与选定的体内和体外准备和程序。我们还需要计算机硬件和软件来提高我们的共焦、多光子和电子显微镜成像的定量分析质量。要求提供支持，以维护和升级数据存档和维护不可或缺的现有服务器。最后，要求提供资源以促进活细胞/活组织成像能力和加强免疫定位研究。总体而言，这次竞争性续签旨在保持我们目前的势头，并在前一次申请中提供的资源基础上再接再厉。我们的目标是通过提供具有成本效益、配备专业人员和管理良好的最先进的生物成像核心，继续提高NINDS资助的研究人员以及他们的研究员和受训人员的研究生产率。这样的核心被认为是NINDS赞助的弗吉尼亚联邦大学神经科学研究持续成功不可或缺的一部分。

DESCRIPTION (provided by applicant): This application requests continuing support for P30 Core Center grant focused on microscopy-based Bioimaging to support the needs of a large number of NINDS-funded investigators resident at Virginia Commonwealth University. The previous application afforded the Principal Investigator the opportunity to develop a contemporary bioimaging facility and target other federal and non-federal sources to allow for its continued expansion, together with the recruitment of a core director possessing recognized expertise in the field of Bioimaging. The equipment, resources, staff and director, all of which were a direct outgrowth of this funded application have had significant impact on NINDS-sponsored and other NIH sponsored research conducted at Virginia Commonwealth University. This competitive renewal asks for continued resources to both maintain and update this highly productive core facility which as noted, serves the needs of NINDS and Neuroscience investigators throughout the Institution. As written, this application seeks support for the technical and administrative staff, instrumentation, and resources needed to support continued training, education and enhanced data analysis and archiving. The requested staff will maintain all instrumentation while providing continued training to the participating investigators, as well as their students and fellows. Additionally, the core staff will participate in select in vivo and in vitro preparations and procedures. Computer hardware and software are also requested to improve the quality of quantitative analysis of our confocal, multi-photon and electron microscopic imaging. Support is requested to maintain and upgrade existing servers that are integral to data archiving and maintenance. Lastly, resources are requested to facilitate live cell / live tissue imaging capabilities and enhance immunolocalization studies. Collectively, this competitive renewal seeks to maintain our current momentum and build upon the resources provided in the previous application. The goal is to continue to enhance the research productivity of our NINDS-funded investigators, as well as their fellows and trainees via the provision of a cost effective, expertly staffed and well managed state-of-the-art bioimaging core. Such a core is considered integral to the continued success of NINDS sponsored Neuroscience research at Virginia Commonwealth University.