VCU Neuroscience Center Core Grant

描述（由申请人提供）：本申请要求继续支持P30核心中心拨款，重点关注基于显微镜的生物成像，以支持大量nind资助的弗吉尼亚联邦大学研究人员的需求。先前的申请为首席研究员提供了开发当代生物成像设备的机会，并针对其他联邦和非联邦来源，以允许其持续扩展，同时招聘一位在生物成像领域拥有公认专业知识的核心主管。设备，资源，人员和主任，所有这些都是该资助申请的直接结果，对nind资助和其他NIH资助在弗吉尼亚联邦大学进行的研究产生了重大影响。这种竞争性的更新需要持续的资源来维持和更新这一高效率的核心设施，如前所述，该设施满足了研究所和整个研究所神经科学研究人员的需要。正如所写的，这个应用程序为技术和管理人员、仪器和资源寻求支持，以支持持续的培训、教育和增强的数据分析和存档。所要求的工作人员将维护所有仪器，同时继续向参与的调查人员及其学生和研究员提供培训。此外，核心工作人员将参与选定的体内和体外准备和程序。计算机硬件和软件也要求提高定量分析的质量，我们的共聚焦，多光子和电子显微镜成像。要求支持维护和升级对数据存档和维护不可或缺的现有服务器。最后，需要资源来促进活细胞/活组织成像能力和加强免疫定位研究。总的来说，这种竞争性的更新旨在保持我们目前的势头，并建立在以前申请中提供的资源。我们的目标是通过提供具有成本效益、专业人员和管理良好的最先进的生物成像核心，继续提高nind资助的研究人员及其研究员和学员的研究效率。这样的核心被认为是NINDS赞助的弗吉尼亚联邦大学神经科学研究持续成功的组成部分。

DESCRIPTION (provided by applicant): This application requests continuing support for P30 Core Center grant focused on microscopy-based Bioimaging to support the needs of a large number of NINDS-funded investigators resident at Virginia Commonwealth University. The previous application afforded the Principal Investigator the opportunity to develop a contemporary bioimaging facility and target other federal and non-federal sources to allow for its continued expansion, together with the recruitment of a core director possessing recognized expertise in the field of Bioimaging. The equipment, resources, staff and director, all of which were a direct outgrowth of this funded application have had significant impact on NINDS-sponsored and other NIH sponsored research conducted at Virginia Commonwealth University. This competitive renewal asks for continued resources to both maintain and update this highly productive core facility which as noted, serves the needs of NINDS and Neuroscience investigators throughout the Institution. As written, this application seeks support for the technical and administrative staff, instrumentation, and resources needed to support continued training, education and enhanced data analysis and archiving. The requested staff will maintain all instrumentation while providing continued training to the participating investigators, as well as their students and fellows. Additionally, the core staff will participate in select in vivo and in vitro preparations and procedures. Computer hardware and software are also requested to improve the quality of quantitative analysis of our confocal, multi-photon and electron microscopic imaging. Support is requested to maintain and upgrade existing servers that are integral to data archiving and maintenance. Lastly, resources are requested to facilitate live cell / live tissue imaging capabilities and enhance immunolocalization studies. Collectively, this competitive renewal seeks to maintain our current momentum and build upon the resources provided in the previous application. The goal is to continue to enhance the research productivity of our NINDS-funded investigators, as well as their fellows and trainees via the provision of a cost effective, expertly staffed and well managed state-of-the-art bioimaging core. Such a core is considered integral to the continued success of NINDS sponsored Neuroscience research at Virginia Commonwealth University.