VCU Neuroscience Center Core Grant

VCU 神经科学中心核心资助

• 批准号: 8139090
• 负责人: John T Povlishock
• 金额: $ 36.36万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8139090
• 关键词: Archives; Cells; Center Core Grants; Computer Hardware; Computer software; Core Facility; Data; Data Analyses; Electrons; Equipment; Funding; Goals; Image; In Vitro; Institution; Life; Maintenance; Microscopic; Microscopy; National Institute of Neurological Disorders and Stroke; Neurosciences; Neurosciences Research; Preparation; Principal Investigator; Procedures; Productivity; Request for Applications; Research; Research Personnel; Resources; Source; Students; Tissues; Training; Training and Education; United States National Institutes of Health; Universities; Update; Virginia; Writing; base; bioimaging; cost effective; improved; in vivo; instrumentation; multi-photon; ranpirnase; success

This application requests continuing support for P30 Core Center grant focused on microscopy-based Bioimaging to support the needs of a large number of NINDS-funded investigators resident at Virginia Commonwealth University. The previous application afforded the Principal Investigator the opportunity to develop a contemporary bioimaging facility and target other federal and non-federal sources to allow for its continued expansion, together with the recruitment of a core director possessing recognized expertise in the field of Bioimaging. The equipment, resources, staff and director, all of which were a direct outgrowth of this funded application have had significant impact on NINDS-sponsored and other NIH sponsored research conducted at Virginia Commonwealth University. This competitive renewal asks for continued resources to both maintain and update this highly productive core facility which as noted, serves the needs of NINDS and Neuroscience investigators throughout the Institution. As written, this application seeks support for the technical and administrative staff, instrumentation, and resources needed to support continued training, education and enhanced data analysis and archiving. The requested staff will maintain all instrumentation while providing continued training to the participating investigators, as well as their students and fellows. Additionally, the core staff will participate in select in vivo and in vitro preparations and procedures. Computer hardware and software are also requested to improve the quality of quantitative analysis of our confocal, multi-photon and electron microscopic imaging. Support is requested to maintain and upgrade existing servers that are integral to data archiving and maintenance. Lastly, resources are requested to facilitate live cell / live tissue imaging capabilities and enhance immunolocalization studies. Collectively, this competitive renewal seeks to maintain our current momentum and build upon the resources provided in the previous application. The goal is to continue to enhance the research productivity of our NINDS-funded investigators, as well as their fellows and trainees via the provision of a cost effective, expertly staffed and well managed state-of-the-art bioimaging core. Such a core is considered integral to the continued success of NINDS sponsored Neuroscience research at Virginia Commonwealth University.

该申请请求继续支持 P30 核心中心拨款，重点关注基于显微镜的生物成像，以支持弗吉尼亚联邦大学驻地的大量 NINDS 资助的研究人员的需求。先前的申请为首席研究员提供了开发现代生物成像设施的机会，并瞄准其他联邦和非联邦来源，以使其继续扩张，同时招募了一位在生物成像领域拥有公认专业知识的核心主任。设备、资源、工作人员和主任，所有这些都是该资助申请的直接产物，对 NINDS 资助的以及其他 NIH 资助的在弗吉尼亚联邦大学进行的研究产生了重大影响。这种竞争性的更新需要持续的资源来维护和更新这个高生产力的核心设施，如上所述，该设施满足整个机构 NINDS 和神经科学研究人员的需求。正如所写的，该应用程序寻求对技术和管理人员、仪器和资源的支持，以支持继续培训、教育和增强的数据分析和归档。所要求的工作人员将维护所有仪器，同时为参与的研究人员及其学生和研究员提供持续培训。此外，核心人员将参与选定的体内和体外准备和程序。还需要计算机硬件和软件来提高共焦、多光子和电子显微成像的定量分析质量。请求支持维护和升级数据归档和维护不可或缺的现有服务器。最后，需要资源来促进活细胞/活组织成像能力并增强免疫定位研究。总的来说，这次竞争性更新旨在保持我们当前的势头，并以先前申请中提供的资源为基础。目标是通过提供具有成本效益、人员配备齐全且管理良好的最先进的生物成像核心，继续提高 NINDS 资助的研究人员及其研究员和受训人员的研究生产力。这样的核心被认为是 NINDS 资助的弗吉尼亚联邦大学神经科学研究持续成功不可或缺的一部分。