VCU Neuroscience Center Core Grant

此申请请求继续支持 P30 核心中心拨款，重点关注基于显微镜的研究 生物成像支持大量 NINDS 资助的弗吉尼亚州调查人员的需求 联邦大学。先前的申请为首席研究员提供了机会 开发现代生物成像设施并瞄准其他联邦和非联邦来源，以使其能够 持续扩张，并聘请了一位在该领域拥有公认专业知识的核心董事 生物成像领域。设备、资源、员工和主管，所有这些都是这种情况的直接产物 资助的申请对 NINDS 资助的研究和 NIH 资助的其他研究产生了重大影响 在弗吉尼亚联邦大学进行。这种竞争性的更新需要持续的资源 维护和更新这一高生产力的核心设施，如上所述，该设施满足 NINDS 和 整个机构的神经科学研究人员。正如所写，本申请寻求支持 支持持续培训所需的技术和行政人员、仪器和资源， 教育和增强的数据分析和归档。所要求的工作人员将维护所有仪器 同时为参与研究人员及其学生和研究员提供持续培训。 此外，核心人员将参与选定的体内和体外准备和程序。 还要求计算机硬件和软件提高我们的定量分析质量。 共焦、多光子和电子显微成像。请求支持维护和升级 数据归档和维护不可或缺的现有服务器。最后，请求资源 促进活细胞/活组织成像能力并增强免疫定位研究。总的来说，这 竞争性更新旨在保持我们当前的势头，并利用现有资源 之前的申请。目标是继续提高 NINDS 资助的研究生产力 通过提供具有成本效益、人员配备熟练且 管理良好的最先进的生物成像核心。这样的核心被认为是持续成功不可或缺的一部分 NINDS 资助了弗吉尼亚联邦大学的神经科学研究。

This application requests continuing support for P30 Core Center grant focused on microscopy-based Bioimaging to support the needs of a large number of NINDS-funded investigators resident at Virginia Commonwealth University. The previous application afforded the Principal Investigator the opportunity to develop a contemporary bioimaging facility and target other federal and non-federal sources to allow for its continued expansion, together with the recruitment of a core director possessing recognized expertise in the field of Bioimaging. The equipment, resources, staff and director, all of which were a direct outgrowth of this funded application have had significant impact on NINDS-sponsored and other NIH sponsored research conducted at Virginia Commonwealth University. This competitive renewal asks for continued resources to both maintain and update this highly productive core facility which as noted, serves the needs of NINDS and Neuroscience investigators throughout the Institution. As written, this application seeks support for the technical and administrative staff, instrumentation, and resources needed to support continued training, education and enhanced data analysis and archiving. The requested staff will maintain all instrumentation while providing continued training to the participating investigators, as well as their students and fellows. Additionally, the core staff will participate in select in vivo and in vitro preparations and procedures. Computer hardware and software are also requested to improve the quality of quantitative analysis of our confocal, multi-photon and electron microscopic imaging. Support is requested to maintain and upgrade existing servers that are integral to data archiving and maintenance. Lastly, resources are requested to facilitate live cell / live tissue imaging capabilities and enhance immunolocalization studies. Collectively, this competitive renewal seeks to maintain our current momentum and build upon the resources provided in the previous application. The goal is to continue to enhance the research productivity of our NINDS-funded investigators, as well as their fellows and trainees via the provision of a cost effective, expertly staffed and well managed state-of-the-art bioimaging core. Such a core is considered integral to the continued success of NINDS sponsored Neuroscience research at Virginia Commonwealth University.