VCU Neuroscience Center Core Grant

此申请要求继续支持P30核心中心赠款，重点是基于显微镜的 生物成像，以支持大量NINDS资助的研究人员在弗吉尼亚州居民的需求 英联邦大学。之前的申请为主要研究者提供了机会， 开发现代生物成像设施，并针对其他联邦和非联邦来源，以允许其 继续扩大，同时征聘一名具有公认的专业知识的核心主任， 生物成像领域。设备、资源、员工和导演，所有这些都是这一计划的直接结果。 资助申请对NINDS和其他NIH资助的研究产生了重大影响 在弗吉尼亚联邦大学进行。这种竞争性的更新要求继续提供资源， 维护和更新这一高效的核心设施，如前所述，服务于NINDS的需求， 整个机构的神经科学研究人员。正如所写的，本申请寻求对以下内容的支持： 支持继续培训所需的技术和行政人员、仪器和资源， 教育和加强数据分析和存档。所要求的工作人员将维护所有仪器 同时为参与调查的人员及其学生和研究员提供持续培训。 此外，核心工作人员将参与选定的体内和体外制剂和程序。 对计算机硬件和软件也提出了更高的要求，以提高定量分析的质量。 共聚焦、多光子和电子显微镜成像。请求提供支持，以维护和升级 现有服务器是数据归档和维护不可或缺的一部分。最后，请拨资源， 促进活细胞/活组织成像能力并增强免疫定位研究。总的来说，这 竞争性的更新旨在保持我们目前的势头，并建立在提供的资源， 以前的应用。我们的目标是继续提高我们的NINDS资助的研究生产力 通过提供具有成本效益、配备专业人员和 最先进的生物成像核心这样一个核心被认为是持续成功的组成部分 NINDS赞助了弗吉尼亚联邦大学的神经科学研究。

This application requests continuing support for P30 Core Center grant focused on microscopy-based Bioimaging to support the needs of a large number of NINDS-funded investigators resident at Virginia Commonwealth University. The previous application afforded the Principal Investigator the opportunity to develop a contemporary bioimaging facility and target other federal and non-federal sources to allow for its continued expansion, together with the recruitment of a core director possessing recognized expertise in the field of Bioimaging. The equipment, resources, staff and director, all of which were a direct outgrowth of this funded application have had significant impact on NINDS-sponsored and other NIH sponsored research conducted at Virginia Commonwealth University. This competitive renewal asks for continued resources to both maintain and update this highly productive core facility which as noted, serves the needs of NINDS and Neuroscience investigators throughout the Institution. As written, this application seeks support for the technical and administrative staff, instrumentation, and resources needed to support continued training, education and enhanced data analysis and archiving. The requested staff will maintain all instrumentation while providing continued training to the participating investigators, as well as their students and fellows. Additionally, the core staff will participate in select in vivo and in vitro preparations and procedures. Computer hardware and software are also requested to improve the quality of quantitative analysis of our confocal, multi-photon and electron microscopic imaging. Support is requested to maintain and upgrade existing servers that are integral to data archiving and maintenance. Lastly, resources are requested to facilitate live cell / live tissue imaging capabilities and enhance immunolocalization studies. Collectively, this competitive renewal seeks to maintain our current momentum and build upon the resources provided in the previous application. The goal is to continue to enhance the research productivity of our NINDS-funded investigators, as well as their fellows and trainees via the provision of a cost effective, expertly staffed and well managed state-of-the-art bioimaging core. Such a core is considered integral to the continued success of NINDS sponsored Neuroscience research at Virginia Commonwealth University.