VCU Neuroscience Center Core Grant

VCU 神经科学中心核心资助

• 批准号: 8145810
• 负责人: John T Povlishock
• 金额: $ 13.19万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145810
• 关键词: Archives; Arts; Cells; Center Core Grants; Computer Hardware; Computer software; Core Facility; Data; Data Analyses; Electrons; Equipment; Funding; Goals; Image; In Vitro; Institution; Life; Maintenance; Microscopic; Microscopy; National Institute of Neurological Disorders and Stroke; Neurosciences; Neurosciences Research; Preparation; Principal Investigator; Procedures; Productivity; Request for Applications; Research; Research Personnel; Resources; Source; Students; Tissues; Training; Training and Education; United States National Institutes of Health; Universities; Update; Virginia; Writing; base; bioimaging; cost effective; improved; in vivo; instrumentation; multi-photon; ranpirnase; success

This application requests continuing support for P30 Core Center grant focused on microscopy-based Bioimaging to support the needs of a large number of NINDS-funded investigators resident at Virginia Commonwealth University. The previous application afforded the Principal Investigator the opportunity to develop a contemporary bioimaging facility and target other federal and non-federal sources to allow for its continued expansion, together with the recruitment of a core director possessing recognized expertise in the field of Bioimaging. The equipment, resources, staff and director, all of which were a direct outgrowth of this funded application have had significant impact on NINDS-sponsored and other NIH sponsored research conducted at Virginia Commonwealth University. This competitive renewal asks for continued resources to both maintain and update this highly productive core facility which as noted, serves the needs of NINDS and Neuroscience investigators throughout the Institution. As written, this application seeks support for the technical and administrative staff, instrumentation, and resources needed to support continued training, education and enhanced data analysis and archiving. The requested staff will maintain all instrumentation while providing continued training to the participating investigators, as well as their students and fellows. Additionally, the core staff will participate in select in vivo and in vitro preparations and procedures. Computer hardware and software are also requested to improve the quality of quantitative analysis of our confocal, multi-photon and electron microscopic imaging. Support is requested to maintain and upgrade existing servers that are integral to data archiving and maintenance. Lastly, resources are requested to facilitate live cell / live tissue imaging capabilities and enhance immunolocalization studies. Collectively, this competitive renewal seeks to maintain our current momentum and build upon the resources provided in the previous application. The goal is to continue to enhance the research productivity of our NINDS-funded investigators, as well as their fellows and trainees via the provision of a cost effective, expertly staffed and well managed state-of-the-art bioimaging core. Such a core is considered integral to the continued success of NINDS sponsored Neuroscience research at Virginia Commonwealth University.

本申请要求继续支持P30核心中心赠款，重点是基于显微镜的生物成像，以支持大量NINDS资助的研究人员居住在弗吉尼亚联邦大学的需求。之前的申请为主要研究者提供了开发现代生物成像设施并瞄准其他联邦和非联邦来源的机会，以允许其继续扩展，同时招募了一名拥有生物成像领域公认专业知识的核心主任。设备，资源，工作人员和董事，所有这些都是这个资助的应用程序的直接产物，有NINDS赞助和其他NIH赞助的研究在弗吉尼亚联邦大学进行了重大影响。这种竞争性的更新要求持续的资源来维护和更新这个高生产力的核心设施，如前所述，服务于整个机构的NINDS和神经科学研究者的需求。正如所写的那样，该应用程序寻求对支持持续培训、教育和增强数据分析和归档所需的技术和管理人员、仪器和资源的支持。所要求的工作人员将维护所有仪器，同时为参与调查的调查员及其学生和研究员提供持续培训。此外，核心工作人员将参与选定的体内和体外制剂和程序。计算机硬件和软件也被要求提高我们的共聚焦，多光子和电子显微镜成像定量分析的质量。请求提供支持，以维护和升级数据存档和维护不可或缺的现有服务器。最后，需要资源来促进活细胞/活组织成像能力和加强免疫定位研究。总的来说，这种竞争性的更新旨在保持我们目前的势头，并在以前的应用程序中提供的资源的基础上。我们的目标是继续提高我们的NINDS资助的研究人员的研究生产力，以及他们的研究员和学员通过提供一个具有成本效益，专业人员和管理良好的国家最先进的生物成像核心。这样的核心被认为是NINDS赞助的弗吉尼亚联邦大学神经科学研究持续成功的组成部分。