Emerging diagnostic and treatment approaches in organ and stem cell transplantation

器官和干细胞移植的新兴诊断和治疗方法

• 批准号: G0600698/1
• 负责人: Steven Sacks
• 金额: $ 268.75万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600698%2F1
• 关键词: Emerging; diagnostic; treatment; approaches; organ

Replacement of diseased organs and cells by healthy tissue is a dream that has partly been realised through progress in transplantation over the last 50 years. However, for transplantation therapy to achieve greater success and on a wider scale, advance is needed in several directions. These include finding supplementary sources of donor tissues and cells that lend themselves for therapy of a larger number of conditions, such as kidney and liver failure, arthritis, diabetes and tooth loss; and a way of ensuring acceptance of the replacement tissue without the need for lifelong drugs that block the immune system. To accelerate progress, experts in basic biology and transplant medicine at King s College London plan to come together in a joint venture with the Medical Research Council, to form the UK s first MRC Centre for Translation of Research in Transplantation. The Centre s mission is to put research in transplantation on a new trajectory to deliver more rapid and effective modes of diagnosis and treatment. The programme of research will apply extensive knowledge of human immunology, stem cell biology, genomics and imaging to develop new areas that will benefit human health. In collaboration with the King s College Centre of Medical Law and Ethics, the MRC Centre will also play a pivotal role in training and education.

用健康的组织替换患病的器官和细胞是一个梦想，这一梦想在一定程度上是通过过去50年来移植技术的进步实现的。然而，为了在更大的范围内取得更大的成功，移植治疗需要在几个方向上取得进展。这些措施包括寻找供体组织和细胞的补充来源，以便治疗更多的疾病，如肾功能衰竭和肝功能衰竭、关节炎、糖尿病和牙齿脱落；以及一种确保替代组织被接受的方法，而不需要终生阻断免疫系统的药物。为了加快进展，伦敦S国王学院的基础生物学和移植医学专家计划与医学研究理事会成立一家合资企业，成立英国S首个移植研究翻译中心。S中心的使命是将移植研究推向新的轨道，提供更快速有效的诊断和治疗模式。该研究计划将应用人类免疫学、干细胞生物学、基因组学和成像的广泛知识，以开发有利于人类健康的新领域。医疗资源中心还将与S国王学院医学法和医德中心合作，在培训和教育方面发挥关键作用。