A UK resource of new models of bone and mineral disorders

基因异常是许多常见的人类疾病的重要原因，这些疾病包括骨骼、关节及其构成中重要的矿物质。这些情况加在一起，几乎影响到所有的人类。对老鼠的研究对于理解基因在这些疾病中的作用很重要，因为有许多可以在老鼠身上进行的实验，这些实验在伦理上和实践上都是人类不可能进行的。目前有许多情况下还没有识别出老鼠模型。该计划将系统地培育新的小鼠品系，以识别与骨质疏松症、骨关节炎、痛风、癌症和肾结石等疾病相关的表型的小鼠。识别这些小鼠涉及的基因将有助于我们理解是什么导致人类出现同样的情况。这一知识将导致针对人类这些疾病的新治疗方法的开发。

Genetic abnormalities are important in the causation of many common human diseases of bones, joints and the minerals important in their makeup. These conditions combined affect nearly all humans. Studies of mice are important in understanding the role of genes in these diseases, as there are many experiments that can be performed with mice that are impossible in humans both ethically and for practical reasons. Currently there are many conditions for which no mouse model has been identified. This programme will systematically breed new mouse strains to identify mice developing phenotypes relevant to conditions such as osteoporosis, osteoarthritis, gout, cancer and kidney stones. Identifying the genes involved in these mice will help us to understand what causes the same conditions in humans. This knowledge will lead to the development of new treatments for these conditions in humans.