A UK resource of new models of bone and mineral disorders

英国骨骼和矿物质疾病新模型资源

• 批准号: G0600702/1
• 负责人: Rajesh Thakker
• 金额: $ 177.15万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600702%2F1
• 关键词: UK; resource; new; models; bone

Genetic abnormalities are important in the causation of many common human diseases of bones, joints and the minerals important in their makeup. These conditions combined affect nearly all humans. Studies of mice are important in understanding the role of genes in these diseases, as there are many experiments that can be performed with mice that are impossible in humans both ethically and for practical reasons. Currently there are many conditions for which no mouse model has been identified. This programme will systematically breed new mouse strains to identify mice developing phenotypes relevant to conditions such as osteoporosis, osteoarthritis, gout, cancer and kidney stones. Identifying the genes involved in these mice will help us to understand what causes the same conditions in humans. This knowledge will lead to the development of new treatments for these conditions in humans.

遗传异常对于许多常见的人类骨骼、关节及其构成中重要的矿物质疾病的病因很重要。这些情况加起来几乎影响到所有人类。对小鼠的研究对于理解基因在这些疾病中的作用非常重要，因为有许多实验可以用小鼠进行，而这些实验在伦理上和实践上都是不可能在人类身上进行的。目前，有许多病症尚未确定小鼠模型。该计划将系统地培育新的小鼠品系，以鉴定出现与骨质疏松症、骨关节炎、痛风、癌症和肾结石等疾病相关表型的小鼠。识别这些小鼠中涉及的基因将有助于我们了解导致人类出现相同病症的原因。这些知识将导致针对人类这些疾病的新疗法的开发。