Resource Center for Alzheimer's and Dementia Research in Asian and Pacific Americans

亚太裔美国人阿尔茨海默病和痴呆症研究资源中心

• 批准号: 10730059
• 负责人: William Tzu-lung Hu
• 金额: $ 75.88万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730059
• 关键词: Acculturation; Adult; Age Years; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Asia; Asian; Asian Americans; Asian Indian; Atherosclerosis; Award; Behavior; Behavioral; Biomedical Research; COVID-19 pandemic; Career Mobility; Caring; Cause of Death; Chinese; Chinese American; Cities; Cognition; Cognitive; Cohort Studies; Common Data Element; Communities; Complement; Country; Data; Data Set; Dementia; Development; Diagnosis; Discipline; Discrimination; Disparate; Disparity; East Asian; Economics; Education; Effectiveness; Elderly; Ethnic Origin; Ethnic Population; Face; Faculty; Foundations; Funding; Goals; Growth; Health; Health Policy; Health Promotion; Immigration; Institution; Internships; Knowledge; Language; Lead; Leadership; Learning; Linguistics; Low Prevalence; Measurement; Mediator; Medicare claim; Mentors; Meta-Analysis; Methodology; Methods; Minority; Minority-Serving Institution; Mission; Modeling; Native Hawaiian or Other Pacific Islander; New Jersey; New York; New York City; Outcome; Participant; Peer Review; Personal Satisfaction; Persons; Phase; Pilot Projects; Policy Maker; Population; Population Study; Prevalence; Prospective Studies; Publications; Recording of previous events; Research; Research Personnel; Resources; Scientist; Social isolation; South Asian; Stress; Subgroup; Surveys; System; Testing; Time; anti-Asian; apprenticeship; brain health; career; career development; cohort; data sharing; dementia care; education research; equity, diversity, and inclusion; experience; health equity; health inequalities; improved; innovation; insight; method development; metropolitan; multidisciplinary; next generation; outreach; pandemic disease; prospective; psychosocial; racial population; racism; recruit; social; social culture; social stigma; success; tool

ABSTRACT Asian and Pacific Americans (APAs) have undergone the greatest growth among all racial/ethnic groups in the U.S. between 2000 and 2020. In the New York City/New Jersey (NYC/NJ) area, older (65+) Asian Indian and Chinese American populations have increased by 73% and 74% over the past ten years. While claims-based studies in the U.S. have previously suggested lower prevalence of Alzheimer’s disease (AD) and related dementias (ADRD) in older APAs, this finding may have resulted from underdiagnosis associated with not having culturally and linguistically appropriate tools, clinicians, or systems. Older APAs with AD/ADRD in the U.S. thus face both the problem of under-diagnosis and under-provision of care as a whole, even as great disparities exist within and between APA subgroups. What’s more, the COVID-19 pandemic and the associated anti-Asian discrimination brought greater social isolation to older Chinese and non-Chinese APA adults over the past three years than other groups. These factors together formed the foundation of the Resource Center for Alzheimer’s and Dementia Research in Asian and Pacific Americans (RCASIA) with missions of 1) increasing scientists underrepresented in AD/ADRD-related Behavioral, Social, and Economic Research biomedical research through innovative models of mentoring and community interaction; 2) advancing the rigor and impact of AD/ADRD pilot studies in older APAs through Common Data Elements and data-sharing; 3) serving as a national resource for linguistically/culturally tested and validated tools to assess cognition, function, and AD/ADRD care in APA populations. Focusing on the theme of People, Culture, Place, Time, RCASIA will leverage strong institutional support and relationships to solicit pilot applications from Early Stage Investigators (ESIs). We will actively engage and encourage applications from ESIs at NYC/NJ-based Minority Serving Institutions through pre-application RCASIA internships and partnership commitments from large funded studies prospectively recruiting disaggregated older APAs. Scientist mentoring will occur in the Research Education Component (co-led by a returning REC Core Lead and a newly recruited yet established AD/ADRD Education/Psychosocial Core Lead) involving mentoring/method-based Pods and ethnicity-based Teams. REC will be supported by the Leadership & Administrative Core, the Measurement & Analytical Core, and Community Liaison & Recruitment Core in selecting each year’s class of RCASIA Scientists, enhancing multi-generational method and career development in Pods, conducting transdisciplinary engagement with Community & Lived Advisors in Teams, and evaluating the outcomes of Scientists, effectiveness of the Pod/Team model, impact of Common Data Elements and data sharing, and long-term relationships between RCASIA and funded Scientists. Returning and new faculty’s commitment to diversity, equity, inclusion, and access and APA brain health will contribute to RCASIA’s goal of becoming the epicenter for AD/ADRD-related Behavioral, Social, and Economic Research in older APA populations.

摘要 亚裔和太平洋裔美国人（APA）在美国所有种族/族裔群体中增长最快。 美国在2000年到2020年之间。在纽约市/新泽西（NYC/NJ）地区，年龄较大（65岁以上）的亚裔印度人和 在过去的十年里，华裔美国人的数量增加了73%和74%。虽然基于索赔 美国的研究先前已经表明阿尔茨海默病（AD）和相关疾病的患病率较低， 痴呆（ADRD）在老年APA，这一发现可能是由于诊断不足， 具有文化和语言上适当的工具、临床医生或系统。患有AD/ADRD的老年APA 因此，在美国，即使作为一个整体， 阿帕亚组内部和亚组之间存在很大差异。更重要的是，COVID-19大流行和 与此相关的反亚裔歧视给中国老年人和非华裔阿帕带来了更大的社会孤立 成年人在过去三年中比其他群体。这些因素共同构成了 亚太裔美国人阿尔茨海默氏症和痴呆症研究资源中心（RCASIA）， 1）越来越多的科学家在AD/ADRD相关的行为，社会和经济方面代表不足 通过指导和社区互动的创新模式进行生物医学研究; 2） 通过通用数据元素，在较老的APA中提高AD/ADRD试点研究的严谨性和影响力， 数据共享; 3）作为国家资源，提供经过语言/文化测试和验证的工具，以评估 阿帕人群的认知、功能和AD/ADRD治疗。围绕“人，文化， 地点，时间，RCASIA将利用强大的机构支持和关系，征求试点申请 早期研究者（ESI）我们将积极参与并鼓励来自ESIs的申请， 纽约/新泽西州的少数民族服务机构通过预申请RCASIA实习和伙伴关系 来自大型资助研究的承诺，前瞻性地招募分解的旧APA。科学家 指导将在研究教育部分进行（由一名返回的REC核心领导和一名新的 已招募但已确定的AD/ADRD教育/心理社会核心负责人）， Pods和基于种族的团队。REC将得到领导和行政核心的支持， 测量和分析核心，社区联络和招聘核心，在选择每年的类 RCASIA科学家，加强多代方法和职业发展的豆荚，进行 与社区和生活顾问团队进行跨学科接触，并评估 科学家、Pod/Team模型的有效性、通用数据元素和数据共享的影响，以及 RCASIA和受资助科学家之间的长期关系。回归和新教师的承诺， 多样性，公平性，包容性和访问以及阿帕大脑健康将有助于RCASIA成为 老年阿帕人群中AD/ADRD相关行为，社会和经济研究的中心。