Resource Center for Alzheimer's and Dementia Research in Asian and Pacific Americans

亚太裔美国人阿尔茨海默病和痴呆症研究资源中心

• 批准号: 10730059
• 负责人: William Tzu-lung Hu
• 金额: $ 75.88万
• 依托单位: RUTGERS BIOMEDICAL AND HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730059
• 关键词: Acculturation; Adult; Age Years; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Area; Asia; Asian; Asian Americans; Asian Indian; Atherosclerosis; Award; Behavior; Behavioral; Biomedical Research; COVID-19 pandemic; Career Mobility; Caring; Cause of Death; Chinese; Chinese American; Cities; Cognition; Cognitive; Cohort Studies; Common Data Element; Communities; Complement; Country; Data; Data Set; Dementia; Development; Diagnosis; Discipline; Discrimination; Disparate; Disparity; East Asian; Economics; Education; Effectiveness; Elderly; Ethnic Origin; Ethnic Population; Face; Faculty; Foundations; Funding; Goals; Growth; Health; Health Policy; Health Promotion; Immigration; Institution; Internships; Knowledge; Language; Lead; Leadership; Learning; Linguistics; Low Prevalence; Measurement; Mediator; Medicare claim; Mentors; Meta-Analysis; Methodology; Methods; Minority; Minority-Serving Institution; Mission; Modeling; Native Hawaiian or Other Pacific Islander; New Jersey; New York; New York City; Outcome; Participant; Peer Review; Personal Satisfaction; Persons; Phase; Pilot Projects; Policy Maker; Population; Population Study; Prevalence; Prospective Studies; Publications; Recording of previous events; Research; Research Personnel; Resources; Scientist; Social isolation; South Asian; Stress; Subgroup; Surveys; System; Testing; Time; anti-Asian; apprenticeship; brain health; career; career development; cohort; data sharing; dementia care; education research; equity, diversity, and inclusion; experience; health equity; health inequalities; improved; innovation; insight; method development; metropolitan; multidisciplinary; next generation; outreach; pandemic disease; prospective; psychosocial; racial population; racism; recruit; social; social culture; social stigma; success; tool

ABSTRACT Asian and Pacific Americans (APAs) have undergone the greatest growth among all racial/ethnic groups in the U.S. between 2000 and 2020. In the New York City/New Jersey (NYC/NJ) area, older (65+) Asian Indian and Chinese American populations have increased by 73% and 74% over the past ten years. While claims-based studies in the U.S. have previously suggested lower prevalence of Alzheimer’s disease (AD) and related dementias (ADRD) in older APAs, this finding may have resulted from underdiagnosis associated with not having culturally and linguistically appropriate tools, clinicians, or systems. Older APAs with AD/ADRD in the U.S. thus face both the problem of under-diagnosis and under-provision of care as a whole, even as great disparities exist within and between APA subgroups. What’s more, the COVID-19 pandemic and the associated anti-Asian discrimination brought greater social isolation to older Chinese and non-Chinese APA adults over the past three years than other groups. These factors together formed the foundation of the Resource Center for Alzheimer’s and Dementia Research in Asian and Pacific Americans (RCASIA) with missions of 1) increasing scientists underrepresented in AD/ADRD-related Behavioral, Social, and Economic Research biomedical research through innovative models of mentoring and community interaction; 2) advancing the rigor and impact of AD/ADRD pilot studies in older APAs through Common Data Elements and data-sharing; 3) serving as a national resource for linguistically/culturally tested and validated tools to assess cognition, function, and AD/ADRD care in APA populations. Focusing on the theme of People, Culture, Place, Time, RCASIA will leverage strong institutional support and relationships to solicit pilot applications from Early Stage Investigators (ESIs). We will actively engage and encourage applications from ESIs at NYC/NJ-based Minority Serving Institutions through pre-application RCASIA internships and partnership commitments from large funded studies prospectively recruiting disaggregated older APAs. Scientist mentoring will occur in the Research Education Component (co-led by a returning REC Core Lead and a newly recruited yet established AD/ADRD Education/Psychosocial Core Lead) involving mentoring/method-based Pods and ethnicity-based Teams. REC will be supported by the Leadership & Administrative Core, the Measurement & Analytical Core, and Community Liaison & Recruitment Core in selecting each year’s class of RCASIA Scientists, enhancing multi-generational method and career development in Pods, conducting transdisciplinary engagement with Community & Lived Advisors in Teams, and evaluating the outcomes of Scientists, effectiveness of the Pod/Team model, impact of Common Data Elements and data sharing, and long-term relationships between RCASIA and funded Scientists. Returning and new faculty’s commitment to diversity, equity, inclusion, and access and APA brain health will contribute to RCASIA’s goal of becoming the epicenter for AD/ADRD-related Behavioral, Social, and Economic Research in older APA populations.

抽象的 在美国所有种族/族裔群体中，亚裔和太平洋裔美国人 (APA) 的增长最快 2000 年至 2020 年间的美国。在纽约市/新泽西州 (NYC/NJ) 地区，老年（65 岁以上）亚裔印度人和 过去十年，美国华裔人口分别增长了 73% 和 74%。虽然基于索赔 美国的研究此前表明阿尔茨海默病 (AD) 及相关疾病的患病率较低 老年 APA 中的痴呆症（ADRD），这一发现可能是由于与非 拥有适合文化和语言的工具、临床医生或系统。具有 AD/ADRD 的旧 APA 因此，美国整体上面临着诊断不足和护理提供不足的问题，即使 APA 亚组内部和亚组之间存在巨大差异。更重要的是，COVID-19 大流行和 相关的反亚裔歧视给老年华人和非华人 APA 带来了更大的社会孤立 过去三年中成年人的比例高于其他群体。这些因素共同构成了 亚太裔美国人阿尔茨海默病和痴呆症研究资源中心 (RCASIA) 1) 增加在 AD/ADRD 相关行为、社会和经济方面代表性不足的科学家的使命 通过指导和社区互动的创新模式进行生物医学研究； 2） 通过通用数据元素提高旧 APA 中 AD/ADRD 试点研究的严谨性和影响力 数据共享； 3) 作为经过语言/文化测试和验证的评估工具的国家资源 APA 人群的认知、功能和 AD/ADRD 护理。围绕“人、文化、 地点、时间，RCASIA 将利用强大的机构支持和关系来征求试点申请 来自早期研究人员 (ESI)。我们将积极参与并鼓励 ESI 的申请 通过预申请 RCASIA 实习和合作伙伴关系，为纽约市/新泽西州的少数族裔服务机构提供服务 来自大型资助研究的承诺，前瞻性地招募分类的旧 APA。科学家 指导将在研究教育部分进行（由回归的 REC 核心领导和新任 REC 共同领导） 招募尚未建立的 AD/ADRD 教育/心理社会核心领导），涉及指导/基于方法 Pod 和基于种族的团队。 REC 将得到领导和行政核心、 测量和分析核心，以及社区联络和招聘核心，用于选择每年的班级 RCASIA 科学家，加强 Pod 中的多代方法和职业发展，进行 与团队中的社区和生活顾问进行跨学科互动，并评估结果 科学家、Pod/团队模型的有效性、通用数据元素和数据共享的影响，以及 RCASIA 与受资助科学家之间建立长期关系。返回和新教师的承诺 多样性、公平性、包容性和可及性以及 APA 大脑健康将有助于实现 RCASIA 成为 老年 APA 人群中 AD/ADRD 相关行为、社会和经济研究的中心。