Role of Oxidative and Nitrative Stress and Histone De-acetylation in Rhinovirus Induced Acute Exacerbations of COPD

氧化应激、硝基应激以及组蛋白去乙酰化在鼻病毒诱导的慢性阻塞性肺病急性加重中的作用

• 批准号: G0600879/1
• 负责人: Sebastian Johnston
• 金额: $ 114.06万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600879%2F1
• 关键词: Role; Oxidative; Nitrative; Stress; Histone

Chronic obstructive pulmonary disease (COPD) or smokers? lung is a growing problem and already one of the commonest causes of death and disability in the UK. COPD accounts for over #800 million in direct healthcare costs. Seventy percent of these costs are related to acute attacks. Acute attacks are also dreaded by COPD sufferers, as they lead to severe breathlessness, prolonged hospitalisation or death. Current therapies are not good at either treatment or prevention of acute attacks. New approaches to therapy are therefore urgently needed. COPD is associated with inflammation in the lung, which gets worse as the disease progresses. Acute attacks also involve inflammation in the lung but how this occurs is very poorly understood. Most acute attacks are caused by common cold viruses, which ?go to the chest?. We plan to carry out detailed studies of virus induced acute attacks of COPD, to understand the molecules switching on inflammation in the lung during these attacks. By identifying the molecules that increase lung inflammation during these attacks, we should be able to identify targets for the development of new therapies for both prevention and treatment of acute attack of COPD. So doing would greatly reduce distress suffered by COPD patients, as well as reducing mortality and health care costs.

慢性阻塞性肺疾病（COPD）或吸烟者？肺是一个日益严重的问题，已经是英国最常见的死亡和残疾原因之一。COPD占直接医疗费用的8亿多。其中70%的成本与急性攻击有关。COPD患者也害怕急性发作，因为它们会导致严重的呼吸困难，延长住院时间或死亡。目前的疗法在治疗或预防急性发作方面都不好。因此，迫切需要新的治疗方法。慢性阻塞性肺病与肺部炎症有关，随着疾病的进展，肺部炎症会变得更糟。急性发作也涉及肺部炎症，但对这种情况如何发生知之甚少。大多数急性发作是由普通感冒病毒引起的，哪种？去胸部？我们计划对病毒诱导的COPD急性发作进行详细研究，以了解在这些发作期间肺部炎症的分子。通过鉴定在这些发作期间增加肺部炎症的分子，我们应该能够确定用于预防和治疗COPD急性发作的新疗法的开发目标。这样做将大大减少COPD患者的痛苦，并降低死亡率和医疗费用。